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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | The role of vena cava filters in the management of venous tbroulboembolism 显示文摘 | HANN C L STREIFF M B | 2005 | Blood Rev2005，19，4： | 1 |
| 3 | Inhibition of Akt inhibits growth of glioblastoma and glioblastoma stem-like cells 显示文摘 | Gallia G L Tyler B M Hann C L | 2009 | Mol Cancer Ther2009，8，2： | 1 |
| 4 | Effect of iron and desferioxamine on cell growth and in vitro ferritin synthesis in human hepatoma cell lines显示文摘 | HANN H W STAHLHUT M W HANN C L | 1990 | Hepatology1990，11，： | 1 |
| 5 | Methods for evaluating crown area profiles of forest stands显示文摘 | DUBRASICH M E HANN D W TAPPEINERⅡJ C | 1997 | Canadian Journal of Forest Research1997，27，3： | 1 |
| 6 | Treatment of medulloblastoma with Hedgehog pathway inhibitor GDC-0449显示文摘 | RUDIN C M HANN C L LATERRA J | 2009 | N Engl J Med2009，361，12： | 1 |
| 7 | Ima- ging the aqueoushumor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro- CT)显示文摘 | HANN C R BENTLEY M D VERCNOCKE A | 2011 | ExpEye Res2011，92，2： | 1 |
| 8 | An in vitro approach for the study of dentinogenesis by organ culture of the dentine-pulp complex from rat incisor teeth 显示文摘 | Sloan A J Shelton R M Hann A C | 1998 | Arch Oral Biol1998，43，6： | 1 |
| 9 | The action of copper sulfate on phenylosazones of the sugars phenyl-D-glucosotriazole显示文摘 | Hann R M Hudson C S | 1944 | J Am Chem Soc1944，66，： | 1 |
| 10 | A comparison of outcomefrom febrile neutropenic episodes in children compared wilhadults: results from four E0RTC studies 显示文摘 | Hann I Viscoli C Paesmans M | 1997 | Br J Haennatol1997，99，3： | 1 |
| 11 | Some Studys on L-Glucoheptulose 显示文摘 | Maclay W D Hann R M Hudson C S | 1942 | J Am Chem Soc1942，64，7： | 1 |
| 12 | The alternatively initiated c-myc proteins differentially regulate transcription through a noncanonical DNA-binding site显示文摘 | Hann S R Dixit M Sears R C | 1994 | Genes Dev1994，，： | 1 |
| 13 | Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449显示文摘 | Rudin C M Hann C L Laterra J | 2009 | N Engl J Med2009，361，12： | 1 |
| 14 | Ultrasonic Irradiation of p - Nitrophenol in Aqueous Solution显示文摘 | HANN M W HUANG H S LIVENGOOD C D | 1992 | Envir - ronmental Pmgess1992，11，3： | 1 |
| 15 | Optimization of an immobilized-cell biocatalyst for production of 4-cyanopentanoic acid显示文摘 | Eugenia C Hann Amy E Sigmund Susan M Hennessey | 2002 | Organic Process Research & Development2002，6，： | 1 |
| 16 | A performance comparison of mobile IPv6,hierarchical mobile IPv6,fast handovers for mobile IPv6 and their combination显示文摘 | XAVIER P C MARC T M HANNES H | 2003 | ACM Mobile Computing and Communications Review2003，7，4： | 1 |
| 17 | Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449显示文摘 | Rudin C M Hann C L Laterra J | 2009 | N Engl J Med2009，361，12： | 1 |
| 18 | Evaluating erosion control measures for biorestoration between the time of soil reinstatement and vegetation establishment显示文摘 | Hann M J Morgan R P C | 2006 | Earth Surface Processes and Landforms2006，31，： | 1 |
| 19 | Sieve: linked data quality assessment and fusion 显示文摘 | PABLO N M HANNES M BIZER C | 2012 | Joint EDBT/ICDT Work- shops2012，，2： | 1 |
| 20 | Phase II study of single-agent navitoclax( ABT-263 ) and biomarker correlates in patients with relapsed small cell lung cancer 显示文摘 | RUDIN C M HANN C L GARON E B | 2012 | Clin Cancer Res2012，18，11： | 1 |
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