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| 1 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 2 | Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours:a comparison with PET/CT显示文摘 | Fischer MA Nanz D Hany T | | 0，，02： | 1 |
| 3 | How useful is PET/CT imaging in the management of post-transplant lym-phoproliferative disease after liver transplantation? 显示文摘 | McCormack L Hany T I Hiibner M | 2006 | Am J Transplant2006，6，7： | 1 |
| 4 | MicroRNA-21 correlates with tumorigenesis in malignant peripheral nerve sheath tumor (MPNST) via programmed cell death pro- tein 4 (PDCD4) 显示文摘 | hani S Kunisada T Morimoto Y | 2012 | J Cancer Res Clin Oncol2012，，9： | 1 |
| 5 | Pelvic and lower extremity arterial imaging: diagnostic performance of three-dimensional contrast-enhanced MR angiography显示文摘 | Ruehm SG Hany TF Pfammater T | 2000 | Am J Roentgenol2000，174，： | 1 |
| 6 | Diagnostic accuracy of whole-bodyMRI/DWI image fusion for detection of malignant tumours: A comparison with PET/CT显示文摘 | Fischer MA Nanz D Hany T | 2011 | European Journal of Radiology2011，21，2： | 1 |
| 7 | Current-mode triple and quadruple langmuir probe methods with applications to flowing pulsed plasmas 显示文摘 | Gatsonis N A Byrne L T Zwahlen J C Pencil E J and Kamhawi Hani | 2004 | IEEE Transactions on Plasma Science2004，32，5： | 1 |
| 8 | Integrated PET/CT for the assessment of coronary artery disease:A feasibility study显示文摘 | Namdar M Hany T F Koepfli P | 2005 | J Nucl Med2005，46，： | 1 |
| 9 | Staging of non-small cell lung cancer with integrated positron emission tomography and computed tomography显示文摘 | LARDINOIS D WEDER W HANY T F | 2003 | N Engl J Med2003，348，25： | 1 |
| 10 | On the Interaction of UV-B radiation(280-315 nm)with water stress in crop plants显示文摘 | Balakumar T Hani B V V Paliwal K | 1993 | Physiol Plant1993，87，： | 1 |
| 11 | Time-resolved three-dimensional contrast-enhanced MR angiography of the peripheral vesscls显示文摘 | Wieben O Grist T M Hany T F | 2002 | Radiology2002，225，5： | 1 |
| 12 | A Case Study on Evaluations of Improvements Implemented by WISE Projects in the Philippines显示文摘 | Takeyama H hany T Taehi N | 2006 | Ind Health2006，44，： | 1 |
| 13 | PET diagnostic accuracy improvement with in line PET-CT system: initial results显示文摘 | HANY T F STEINERT H C GOERRES G W | 2002 | Radiology2002，225，2： | 1 |
| 14 | Fertility of mice receiving vit-rified adult mouse ovaries显示文摘 | Hani T Tachibe T Shingai S | 2006 | Reproduction2006，131，4： | 1 |
| 15 | Detection of HIV-1 viruses in tears of patients even under long-term HAART 显示文摘 | HanY WuN ZhuW LiY ZuoL YeJ QiuZ XieJ Li T | 2011 | AIDS2011，25，15： | 1 |
| 16 | Pelvic and lower extremity arterial imaging:diagnostic performance of three-dimensional contrast-enhanced MR angiography显示文摘 | Ruehm SG Hany TF Pfammatter T | 2000 | AJR2000，174，4： | 1 |
| 17 | Variation of 2-acetyl-l-pyrroline con- centration in aromatic rice grains collected in the same region in Japan and factors affecting its concentration显示文摘 | hani T Tamaki M Hayata Y | 2004 | Plant Prod Sci2004，7，2： | 1 |
| 18 | Toward Non-Toxic Anti- fouling: Synthesis of Hydroxy -, Cinnamic Acid -, Sulfate -, and Zosteric Acid- Labeled Poly 显示文摘 | Hany R Bohlen C Geiger T | 2004 | Biomacromolecules2004，5，4： | 1 |
| 19 | Model for coordination of com- munity health services and health and welfare services offered by health insurance societies显示文摘 | Terada H hani T Shoji S | 2003 | Sangyo Eiseigaku Zasshi2003，45，2： | 1 |
| 20 | Effect of pressure at primary drying of freeze-drying mouse sperm reproduction ability and preservation potential 显示文摘 | Kawase Y Hani T Kamada N | 2007 | Reproduction2007，133，： | 1 |
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