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185篇 您的检索式:作者名="Handyside"
    题名 作者 年代 出处 被引量
1Scoring of sperm chromosomal abnormalities by manual and automated approaches:qualitative and quantitative comparisons显示文摘精子 disomy 的层次相关到不孕的层次,现在是众所周知的(象另外的因素一样) 。永久维持 aneuploidy 到经历 intracytoplasmic 精子注射(ICSI ) 的不肥沃的男性的后代的风险在帮助复制成为了一个暑热地辩论的问题;然而,在那里仍然是障碍到为精子提供在一个临床的背景屏蔽的 disomy 的实际实现。主要障碍是花到分析的操作员时间一统计上有意义(足够) 房间的数字。“自动化点数”的介绍软件鈥揾a rdware 联合介绍一个潜在的解决方案给这个问题。在这初步的确认研究,我们分析了 10 个病人,手工地并且用一个商业地可得到的点阻止。结果显示出在两条途径之间的统计上重要的关联因为当为双精子得分时,精子 disomy,而是没有关联得分被发现。对后者的最可能的解释作为一个单个双房间是二个仔细联系的精子头的明显的 overscoring。这些结果,和将续起的类似的进一步的研究,通知费用鈥揵e nefit 的帮助分析那单个诊所需要执行以便决定是否采用从要求 ICSI 治疗的人为对精子的评价作为一个平淡的工具屏蔽的精子 aneuploidy。Helen G. Tempest Siu Yan Cheng David J. Gillott Alan H. Handyside Alan R. Thomhill Darren K. Griffin 2010Asian Journal of Andrology2010,12,2:2
2Mosaieism of autosomes and sex chromosomesin morphologieally normal,monospermic Preimplantation humanembryos显示文摘Harper JC Coonen E Handyside AH 1995Prenat Diagn1995,15,1:1
3Oocyte regulation of anti-Müllerian hormone expression in granulosa cells during ovarian follicle development in mice显示文摘Salmon NA Handyside AH Joyce IM 2004Dev Biol2004,266,1:1
4Detailed chromosome and molecular genetic analysis of single cell by whole genome amplification and comparative genome hybridiation显示文摘 Sherlock JK Handyside AH 1999Nucleic Acid Res1999,27,4:1
5Oocyte regulation of anti-Müllerian hormone expression in granulosa cells during ovarian follicle development in mice 显示文摘Salmon NA Handyside AH Joyce IM 2004Dev Biol2004,2661,:1
6Noninvasive measurement of glucose and pyruvate uptake by individual human oocytes and premplantation embryos 显示文摘Hardy K Hooper MA Handyside AH 1989Hum Reprod1989,4,:1
7Genetic analysis of DNA from single human oocytes: a model for preimplantation diagnosis of cystic fibrosis 显示文摘Coutelle C Williams C Handyside A 1989BMJ1989,299,6690:1
8Selection criteria for human embryo transfer: a comparison of pyruvate uptake and morphology显示文摘Conaghan J Hardy K Handyside AH 1993J Assist Reprod Genet1993,10,:1
9Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification显示文摘 Kontogianni EH Hardy K 1990Natrue1990,344,:1
10Detailed chrosome and molecular genetic analysis of single cell by whole genome amplification and comparative genome hybridization显示文摘 Sherlock JK Handyside AH 1999Nucleic Acid Res1999,27,4:1
11Detailed chromosomal and molecular genetic analysis of single cells by Whole genome amplification and comparative genomic hybridization显示文摘 Sherlock JK Handyside AH 1999Nucleic Acid Res1999,27,:1
12XIST expression from the maternal Ⅹ-chromosome in human male preimplantation embryos at the blastocyst stage显示文摘 Winslon RM Handyside AH 1997Hum Mol Genet1997,6,8:1
13HPRT-deficient (Lesch- Nyhan) mouse embryos derived from germline colonization by cultured cells 显示文摘Hooper M Hardy K Handyside A 1987Nature1987,326,6110:1
14Reduced allele dropout in single - cell ananlysis for preimplantation genetic diagnosis of dystic fibrosis显示文摘Ray PF Winston RML Handyside AH 1996J Assist Reprod Genet1996,13,:1
15Pregnancies fi'om biopsied human preimplantation embryos sexed by Y-specific DNA amplification显示文摘Handyside AH Kontogianni EH Hardy K 1990Nature1990,344,6268:1
16Clinical im- plications of the smear layer in endodontics: a review 显示文摘Torabinejad M Handysides R Khademi AA 2002Oral Surg Oral Med Oral Pathol Oral Radiol Endod2002,94,6:1
17Temporal and spatial patterns of the synthesis of tissue-specific polypeptides in the preimplantation mouse embryo显示文摘Handyside A Johnson M 1978J Embryol Exp Morphol1978,44,:1
18Sexing of preimplantation mouse embryos by measurement of X-linked gene dosage in a single blastomere显示文摘MONK M HANDYSIDE A H 1988J Reprod Fert1988,82,:1
19Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes显示文摘Handyside AH Harton GL Mariani B 2010J Med Genet2010,47,10:1
20Isothermal whole genome amplification from single and small numbers of cells : a new era for preimplantation genetic diagnosis of inherited disease显示文摘Handyside A H Robinson M D Simpson R J 2004Mol Hum Reprod2004,10,:1
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