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| 1 | Meshless Method for Analysis of Permeable Breakwaters in the Proximity of A Vertical Wall显示文摘In the present work, the improved version of the meshless singular boundary method(ISBM) is developed for analyzing the performance of bottom standing submerged permeable breakwaters in regular normally incident waves and in the proximity of a vertical wall. Both single and dual prismatic breakwaters of rectangular and trapezoidal forms are examined. The physical problem is cast in terms of the Laplace equation governing an irrotational flow and incompressible fluid motion with appropriate mixed type boundary conditions, and solved numerically using the ISBM. To model the permeability of the breakwaters fully absorbing boundary conditions are assumed. Numerical results are presented in terms of hydrodynamic quantities of the reflection coefficients. These are firstly validated against the results of a multi-domain boundary element method(BEM) developed independently for a previous study. The agreement between the results of the two methods is excellent. The coefficients of reflection are then computed and discussed for a variety of structural conditions including the breakwaters height, width, spacing, and absorbing permeability. Effects of the proximity of the vertical plane wall are also investigated. The breakwater's width is found to have only marginal effects compared with its height. Permeability tends to decrease the minimum reflections. These coefficients show periodic variations with the spacing relative to the wavelength. Trapezoidal breakwaters are found to be more cost-effective than the rectangular breakwaters. Dual breakwater systems are confirmed to perform much better than single structures. | Nadji CHIOUKH Karim OUAZZANE Yal??n YüKSEL Benameur HAMOUDI Esin ?EVIK | 2019 | China Ocean Engineering2019，33，2： | 6 |
| 2 | A Multi-Domain Boundary Element Method to Analyze the Reflection and Transmission of Oblique Waves From Double Porous Thin Walls显示文摘In the present paper, we examine the performance of an efficient type of wave-absorbing porous marine structure under the attack of regular oblique waves by using a Multi-Domain Boundary Element Method(MDBEM). The structure consists of two perforated vertical thin barriers creating what can be called a wave absorbing chamber system. The barriers are surface piercing, thereby eliminating wave overtopping. The problem of the interaction of obliquely incident linear waves upon a pair of perforated barriers is first formulated in the context of linear diffraction theory. The resulting boundary integral equation, which is matched with far-field solutions presented in terms of analytical series with unknown coefficients, as well as the appropriate boundary conditions at the free surface, seabed, and barriers, is then solved numerically using MDBEM. Dissipation of the wave energy due to the presence of the perforated barriers is represented by a simple yet effective relation in terms of the porosity parameter appropriate for thin perforated walls. The results are presented in terms of reflection and transmission coefficients. The effects of the incident wave angles, relative water depths, porosities, depths of the walls, and other major parameters of interest are explored. | Yamina Bakhti Nadji Chioukh Benameur Hamoudi Mohamed Boukhari | 2017 | Journal of Marine Science and Application2017，16，3： | 5 |
| 3 | Insight into molecular mechanisms underlying hepatic dysfunction in severe COVID-19 patients using systems biology显示文摘BACKGROUND The coronavirus disease 2019(COVID-19),a pandemic contributing to more than 105 million cases and more than 2.3 million deaths worldwide,was described to be frequently accompanied by extrapulmonary manifestations,including liver dysfunction.Liver dysfunction and elevated liver enzymes were observed in about 53%of COVID-19 patients.AIM To gain insight into transcriptional abnormalities in liver tissue of severe COVID-19 patients that may result in liver dysfunction.METHODS The transcriptome of liver autopsy samples from severe COVID-19 patients against those of non-COVID donors was analyzed.Differentially expressed genes were identified from normalized RNA-seq data and analyzed for the enrichment of functional clusters and pathways.The differentially expressed genes were then compared against the genetic signatures of liver diseases including cirrhosis,fibrosis,non-alcoholic fatty liver disease(NAFLD),and hepatitis A/B/C.Gene expression of some differentially expressed genes was assessed in the blood samples of severe COVID-19 patients with liver dysfunction using qRT-PCR.RESULTS Analysis of the differential transcriptome of the liver tissue of severe COVID-19 patients revealed a significant upregulation of transcripts implicated in tissue remodeling including G-coupled protein receptors family genes,DNAJB1,IGF2,EGFR,and HDGF.Concordantly,the differential transcriptome of severe COVID-19 liver tissues substantially overlapped with the disease signature of liver diseases characterized with pathological tissue remodeling(liver cirrhosis,Fibrosis,NAFLD,and hepatitis A/B/C).Moreover,we observed a significant suppression of transcripts implicated in metabolic pathways as well as mitochondrial function,including cytochrome P450 family members,ACAD11,CIDEB,GNMT,and GPAM.Consequently,drug and xenobiotics metabolism pathways are significantly suppressed suggesting a decrease in liver detoxification capacity.In correspondence with the RNA-seq data analysis,we observed a significant upregulation of DNAJB1 and HSP90AB1 as well as significant downregulation of CYP39A1 in the blood plasma of severe COVID-19 patients with liver dysfunction.CONCLUSION Severe COVID-19 patients appear to experience significant transcriptional shift that may ensue tissue remodeling,mitochondrial dysfunction and lower hepatic detoxification resulting in the clinically observed liver dysfunction. | Sarah Musa Hammoudeh Arabella Musa Hammoudeh Poorna Manasa Bhamidimarri Bassam Mahboub Rabih Halwani Qutayba Hamid Mohamed Rahmani Rifat Hamoudi | 2021 | World Journal of Gastroenterology2021，27，21： | 2 |
| 4 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 5 | Wet oxidation of phenolic solutions over heterogeneous catalysts: degradation profile and catalyst behaviour显示文摘 | HAMOUDI S LARACHI F SAYARI A | 1988 | Catalysis1988，177，： | 2 |
| 6 | 显示文摘 | Pillai S K Hamoudi S Belkacemi K J | 2013 | Appl Catal A-Gen2013，455，： | 1 |
| 7 | Wet oxidation of phenolic solutions over heterogeneous catalysts: Degradation profile and catalyst behavior显示文摘 | Hamoudi S | 1998 | Journal of Catalysis1998，177，： | 1 |
| 8 | Sulfonic acid functinalized periodic mesoporous organosilica 显示文摘 | Hamoudi S Kaliaguine S | 2003 | Microporous and Mesoporous Materials2003，59，： | 1 |
| 9 | 显示文摘 | Sayari A Belkacemi K | 2000 | Catalysis Today2000，62，： | 1 |
| 10 | Comparative laboratory evaluation of three antigen detection methods for diagnosis of Haemophilus influenzae type b disease显示文摘 | Marcon MJ Hamoudi AC Cannon HJ | 1984 | J Ctin Microbiol1984，19，3： | 1 |
| 11 | Adsorption of phosphate and nitrate anions on ammonium-functionalized MCM-48: Effects of experimental conditions 显示文摘 | Rabih Saad Khaled Belkacemi Safia Hamoudi | 2007 | Journal of Colloid and Interface Science2007，311，2： | 1 |
| 12 | Periodic mesoporous silica-based organic-inorganic nanocomposite materials 显示文摘 | Sayari A Hamoudi S | 2001 | Chemistry of Materials2001，13，10： | 1 |
| 13 | Wet oxidation of phenolic solutions overheterogeneous catalysts:degradation profile and catalyst behaviour显示文摘 | Hamoudi S Larachi F Sayari A | 1998 | Journal of Catalysis1998，177，： | 1 |
| 14 | Acute fatty liver of pregnancy 显示文摘 | Mjahed K Charra B Hamoudi D | 2006 | Archives of Gynecology and Obstetrics2006，274，： | 1 |
| 15 | p53 abnormalities in B- cell prolymphocytic leukemia显示文摘 | Lens D De Schouwer PJ Hamoudi RA | 1997 | Blood1997，89，6： | 1 |
| 16 | A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts 显示文摘 | Malley DS Hamoudi RA Kocialkowski S | 2011 | Acta Neuropathol2011，121，5： | 1 |
| 17 | Equilibrium existence in the circle model with linear quadratic transport cost显示文摘 | de Frutos M A Hamoudi H Jarque X | 1999 | Regional Science and Urban Economics1999，29，5： | 1 |
| 18 | Spatial competition with concave transport costs显示文摘 | de Frutos A Hamoudi H Xarque X | 2002 | Regional Science and Urban Economics2002，32，4： | 1 |
| 19 | 显示文摘 | Hamoudi S Yang Y Moudrakovski Y L J R Ripmeeser | 2000 | Chem Mater2000，12，： | 1 |
| 20 | Characterization of spent MnO2/CeO2 wet oxidation catalyst by TPO-MS, XPS, and SSIMS显示文摘 | HAMOUDI S LARACHI F ADNOT A SAYSRI A | 1999 | J Catal1999，185，2： | 1 |
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