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| 1 | Preserved liver regeneration capacity after partial hepatectomy in rats with non-alcoholic steatohepatitis显示文摘AIM To evaluate the liver regeneration capacity(LRC) after partial hepatectomy(PH) in experimental non-alcoholic steatohepatitis(NASH).METHODS Fifty-four female rats were fed a high-fat, high-cholesterol diet(HFCD, 65% fat, 1% cholesterol) or standard diet(STD) for 16 wk. A 70% PH was performed and the animals were euthanised before PH or 2 or 5 d postPH. LRC was evaluated using: The total number of Ki-67 positive hepatocytes in the caudate lobe, N(Ki-67, lobe) evaluated in a stereology-based design, the regenerated protein ratio(RPR), prothrombin-proconvertin ratio(PP), and m RNA expression of genes related to regeneration.RESULTS The HFCD NASH model showed significant steatosis with ballooning and inflammation, while no fibrosis was present. Mortality was similar in HFCD and STD animals following PH. HFCD groups were compared to respective STD groups and HFCD animals had a significantly elevated alanine transaminase at baseline(P < 0.001), as well as a significantly elevated bilirubin at day 2 after PH(P < 0.05). HFCD animals had a higher N(Ki-67, lobe) at baseline,(P < 0.0001), day 2 after PH(P = 0.06) and day 5 after PH(P < 0.025). We found no significant difference in RPR or PP neither 2 or 5 d post-PH. Expression of liver regeneration genes(e.g., hepatic growth factor) was higher at both day 2 and 5 post-PH in HFCD groups(P < 0.05).CONCLUSION NASH rats had a preserved LRC after hepatectomy when compared to STD rats. The methods and models of NASH are essential in understanding and evaluating LRC. | David Haldrup Sara Heeboll Karen Louise Thomsen Kasper Jarlhelt Andersen Michelle Meier Frank Viborg Mortensen Jens Randel Nyengaard Stephen Hamilton-Dutoit Henning Gronbaek | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 2 | Prog- nostic significance of aberrantly silenced ANPEP expres- sion in prostate cancer显示文摘 | SCrensen KD Abildgaard MO Haldrup C | 2013 | Br J Cancer2013，108，2： | 1 |
| 3 | Positive selection: a plant selection principle based on xylose isomerase, an enzyme used in the food industry显示文摘 | Haldrup A Petterson S G Okkels F T | 1998 | Plant Cell Reports1998，18，1： | 1 |
| 4 | Plant selection principle based on xylose merse显示文摘 | Haldrup A Noerremark M Okkels F T | 2001 | In Vitro Cell Dev Biol-Plant2001，37，： | 1 |
| 5 | The Effects of Additive Outliers on Tests for Unit Root and Cointegcation 显示文摘 | FRANSES P H Haldrup N | 1994 | Journal of Business & Economic Statistics1994，，12： | 1 |
| 6 | Photoinhibition of photo system I显示文摘 | SCHELLER H V HALDRUP A | 2005 | Planta2005，221，： | 1 |
| 7 | The xylose isomerase gene from themoanaerobac- terium themosulfurogenes allows effective selection of transgenic plant cells using D-xylose as the selection agent显示文摘 | Haldrup A Petersen S G Okkels F T | 1998 | Plant Mol Bio11998，37，： | 1 |
| 8 | Positive selection: a plant selection principle based on xylose isomerase,an enzyme used in the food industry显示文摘 | Haldrup A Petersen S G Okkels F T | 1998 | Plant Cell Reports1998，18，： | 1 |
| 9 | Plant selection principle based on xylose isomerase显示文摘 | Haldrup A Noerremark M Okkels F T | 2001 | In Vitro Cellular and Development Biology - Plant2001，37，2： | 1 |
| 10 | The family gaze 显示文摘 | Haldrup M Larsen J | 2003 | Tourist Studies2003，3，1： | 1 |
| 11 | The xylose isomerase gene from Thermoanaerobacterium thermosulfurogenes allows effective selection of transgenic plant cells using D-xylose as the selection agent显示文摘 | ANNA HALDRUP STEEN GULDAGER PETERSEN FINN THYGE OKKELS | 1998 | Plant Molecular Biology1998，，37： | 1 |
| 12 | The xylose isomerase gene from Thermoanaerobacterium thermosulfurogenes allows effective selection of transgenic plant cells using D-xylose as the selection agent显示文摘 | Haldrup A Petersen G S Okkels F T | 1998 | Plant Molecular Biology1998，37，： | 1 |
| 13 | Positive selection: a plant selection principle based on xylose isomerase, an enzyme used in the food industry显示文摘 | HALDRUP A PETERSEN S G OKKELS F T | 1998 | Plant Cell Reports1998，，18： | 1 |
| 14 | Laid-back mobilities: Second-home holidays in time and space显示文摘 | HALDRUP M | 2004 | Tourism Geography2004，6，4： | 1 |
| 15 | Cosuppression of photosystem Ⅰ subunit PSI-H in Arabidopsis thaliana显示文摘 | Helle Naver Anna Haldrup Henrik Vibe Scheller | 1999 | J Biol Chem1999，274，10： | 1 |
| 16 | The family gaze显示文摘 | Haldrup M Larsen J | 2003 | Tourist Studies2003，3，1： | 1 |
| 17 | Pieoseeond time- resolved laser pump/X - ray probe experiments using a gated single-photon-counting area detector 显示文摘 | Ejdrnp T Lemke H T Haldrup K | 2009 | Journal of synchrotron radiation2009，16，3： | 1 |
| 18 | The PSI-H subunit of photosystem Ⅰ is essential for state transitions in plant photosynthesis显示文摘 | Lunde C P E Jensen A Haldrup | 2000 | Nature2000，408，： | 1 |
| 19 | Positive selection:a plant selection principle based on xylose isomerase,an enzyme used in the food industry显示文摘 | HALDRUP A PTTERSON S G OKKELS F T | 1998 | Plant Cell RepoDmrts1998，18，1： | 1 |
| 20 | The xylose isomerase gene fi:om Thermoanaerobacterium themosulfurogenes allows effective selection of transgenic plant cells using D-xylose as the selection agent显示文摘 | Haldrup A Petersen S G Okkels F T | 1998 | Plant Mol Bio1998，37，： | 1 |
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