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| 1 | Impact of gastroesophageal reflux control through tailored proton pump inhibition therapy or fundoplication in patients with Barrett's esophagus显示文摘AIM To determine the impact of upwards titration of proton pump inhibition(PPI) on acid reflux, symptom scores and histology, compared to clinically successful fundoplication.METHODS Two cohorts of long-segment Barrett's esophagus(BE) patients were studied. In group 1(n = 24), increasing doses of PPI were administered in 8-wk intervals until acid reflux normalization. At each assessment, ambulatory 24 h p H recording, endoscopy with biopsies and symptom scoring(by a gastroesophageal reflux disease health related quality of life questionnaire, GERD/HRLQ) were performed. Group 2(n = 30) consisted of patients with a previous fundoplication. RESULTS In group 1, acid reflux normalized in 23 of 24 patients, resulting in improved GERD/HRQL scores(P = 0.001), which were most pronounced after the starting dose of PPI(P < 0.001). PPI treatment reached the same level of GERD/HRQL scores as after a clinically successful fundoplication(P = 0.5). Normalization of acid reflux in both groups was associated with reduction in papillary length, basal cell layer thickness, intercellular space dilatation, and acute and chronic inflammation of squamous epithelium. CONCLUSION This study shows that acid reflux and symptom scores co-vary throughout PPI increments in long-segment BE patients, especially after the first dose of PPI, reaching the same level as after a successful fundoplication. Minor changes were found among GERD markers at the morphological level. | Francisco Baldaque-Silva Michael Vieth Mumen Debel Bengt Hakanson Anders Thorell Nuno Lunet Huan Song Miguel Mascarenhas-Saraiva Gisela Pereira Lars Lundell Hanns-Ulrich Marschall | 2017 | World Journal of Gastroenterology2017，23，17： | 3 |
| 2 | Surface-enhanced Raman scattering on dual-layer metallic gratingstructures显示文摘Dual-layer Metallic grating(DMG)structures as surface-enhanced Raman scattering(SERS)substrates are studied using benzenethiol as the probe analyte.The DMG structure consists of a SiO2 grating and 100-nm-thick gold coating layers.An enhancement factor of 105 is achieved by optimizing the SiO 2 grating height within the range from 165 to 550 nm.The enhancement factor dependence on the SiO2 grating height is due to the surface plasmon excitation,which is dependent on the polarization of the incident light,and confirmed by finite difference time domain simulations.This study demonstrates the advantages of high uniformity,reproducibility and sensitivity in the DMG structures for SERS applications. | GUAN ZhiQiang HAKANSON Ulf ANTTU Nicklas WEI Hong XU HongQi MONTELIUS Lars XU HongXing | 2010 | Chinese Science Bulletin2010，55，24： | 3 |
| 3 | An ecological risk index for aquatic pollution control- A sedimentological approach显示文摘 | Hakanson L | 1980 | Water Research1980，14，8： | 1 |
| 4 | Proghrelin-derived peptides influence the secretion of insulin, glucagon, pancreatic polypeptide and somatostatin: a study on isolated islets from mouse and rat pancreas显示文摘 | Qader S S Hakanson R Rehfeld J F | 2008 | Regul Pept2008，146，： | 1 |
| 5 | An ecology risk index for aquatic pollution contml:a sedi- mentologieal approach 显示文摘 | HAKANSON L | 1980 | Water Res1980，14，8： | 1 |
| 6 | An ecological risk index for aquatic pollution control: A sedimentological approach 显示文摘 | HAKANSON L | 1980 | Water Research1980，14，8： | 1 |
| 7 | An ecological risk index for quality pollution control : A sedimentological approach 显示文摘 | HAKANSON L | 1980 | Water Research1980，14，8： | 1 |
| 8 | An ecological risk index for quality pollution control : a sediment ecological approach 显示文摘 | Hakanson L | 1980 | Water Res1980，14，： | 1 |
| 9 | An ecological risk index for aquatic pollution control:a sediment ecological approach显示文摘 | Hakanson L | 1980 | Water Research1980，14，： | 1 |
| 10 | An ecology risk index for aquatic pollution control, a sedimentological approach 显示文摘 | Hakanson L | 1980 | Water Res1980，14，8： | 1 |
| 11 | An ecological risk index for aquatic pollu- tion control: A sediment ecological approach 显示文摘 | Hakanson L | 1980 | Water Research1980，14，8： | 1 |
| 12 | An ecological risk index for aquatic pollution control: A sedimentulogical approach显示文摘 | Hakanson L | 1980 | Waler Research1980，14，8： | 1 |
| 13 | An ecological risk index for aquaticpollution control:a sedimentological approach显示文摘 | HAKANSON L | 1980 | Water Res1980，14，8： | 1 |
| 14 | An ecological risk index for aquatic pollution control-asedimentological approach显示文摘 | Lars Hakanson | 1980 | Water Research1980，14，： | 1 |
| 15 | An ecological risk index for aquatic pollution control--A sedimentological approach显示文摘 | Hakanson L | 1980 | Water Research1980，14，1： | 1 |
| 16 | Failure of exchange reamed intramedullary nails for ununited femoral shaft fractures显示文摘 | Weresh MJ Hakanson R Stover MD | 2000 | J Orthop Trauma2000，14，5： | 1 |
| 17 | An ecological risk index for aquatic pollution control,A sedimentological approach显示文摘 | HaKANSON L | 1980 | Water Res1980，14，： | 1 |
| 18 | An ecological risk index for aquatic pollution control: a sediment eological approach显示文摘 | HAKANSON L | 1980 | Water Res1980，14，： | 1 |
| 19 | An ecological risk index for aquatic pollution control-a sedimentological approach显示文摘 | Hakanson L | 1980 | Water Research1980，14，： | 1 |
| 20 | Ecological risk index for aquatic pollution control:a sedimentological approach 显示文摘 | HAKANSON L | 1980 | Water Research1980，14，8： | 1 |
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