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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | Interleukin:a common endogenous mediator of information and the local shwqrtzman reaction显示文摘 | Beck G Habicht G S Benach J L | 1986 | J Immunol1986，136，： | 2 |
| 3 | Anthropometric reference data for international use:recommendations from a World Health Organization Expert Committee显示文摘 | DE ONIS M HABICHT J P | 1996 | A J Clin Nutr1996，64，： | 1 |
| 4 | Diversity of Sulfur Isotope Fractionations by Sulfate-Reducing Prokaryotes显示文摘 | Detmers J Brüchert V Habicht K S | 2001 | Applied and Environmental Microbiology2001，67，2： | 1 |
| 5 | Regular follow-up after curative resection of non-small cell lung cancer:a real benefit for patients?显示文摘 | Egermann U Jaeggi K Habicht JM | 2002 | Eur Respir J2002，19，3： | 1 |
| 6 | Quantum chemical analysis of structure-activity relationships in nonsteroidal anti-inflammatory drugs 显示文摘 | Mahler E L Habicht J Brnne K | 1982 | Mol Pharmacol1982，22，3： | 1 |
| 7 | A multicenter trial evaluation of the fibrin/fibrinogen degradation products test for detection and monitoring of bladder cancer显示文摘 | Schmetter BS Habicht KK Lamm DL | 1997 | J Urol1997，158，： | 1 |
| 8 | The Archean sulfur cycle and the early history of atmospheric oxygen显示文摘 | CANFIELD D E HABICHT K S THAMDRUP B | 2000 | Science2000，288，4： | 1 |
| 9 | Sulfur isotope fractionation during bacterial sulfate reduction in organic-rich sediments显示文摘 | Habicht K S Canfield D E | 1997 | Geochimica et Cosmochimica Acta1997，61，24： | 1 |
| 10 | Sulphate-reduc-ing bacteria and their activities in cyanobacterial mats of Solar Lake (Sinai, Egypt)显示文摘 | Teske A Ramsing N B Habicht K S | 1998 | Applied and Environmental Micro biology1998，64，： | 1 |
| 11 | The emerging role of T cell lg mucin 1 in alloimmune responses in an experimental mouse lransplant model显示文摘 | Ueno T Habicht A Clarkson MR et a | 2008 | J Clin Invest2008，118，： | 1 |
| 12 | Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritubular and glomerular capillaries: a contribution of humoral immunity to chronic allograft rejection 显示文摘 | Regele H Bohmig GA Habicht A | 2002 | J Am Soc Nephrol2002，13，9： | 1 |
| 13 | Capillary deposition of complement split product C4d in renal allografts is associated with basement membrane injury in peritublar and glomerular capillaries:a contribution of humoral immunity to chronic allograft rejection显示文摘 | Regele H Bohmig GA Habicht A | 2002 | J Am Soc Nephrol2002，13，9： | 1 |
| 14 | Diagnosis and treatment of invasive pulmonary aspergillosis in neutropenic patients显示文摘 | Reichenberger F Habicht JM Gratwohl A | 2002 | Eur Respir J2002，19，4： | 1 |
| 15 | Capil-lary CA deposition in kidney allograft:A specificmarker of alloantibody-dependents ftinjury显示文摘 | BOHMIG G A EXNER M HABICHT A | 2002 | J AmSoe Nephrol2002，13，： | 1 |
| 16 | Sulfur isotope fraction- ation during bacterial reduction and disproportionation of thiosul- fate and sulfite 显示文摘 | Habicht K Canfield D E Ret hemeier J | 1998 | Geochimica et Cosmochimica Acta1998，62，15： | 1 |
| 17 | Capillary C4d deposition in kidney allografts: a specific marker of alloantibody-dependent graft injury显示文摘 | Bohmig G A Exner M Habicht A Schillinger M Lang U Kletzmayr J | 2002 | J Am Soc Nephrol2002，13，： | 1 |
| 18 | An in vitro digestion/Caco-2 cell culture system accurately predicts the effects of ascorbic acid and polyphenolic compounds on iron bioavailability in humans 显示文摘 | Yun S Habicht JP Miller DD | 2004 | J Nutr2004，134，10： | 1 |
| 19 | Quality im- provement in the Estonian health system-assessment of progress us- ing an intenmtional tool显示文摘 | KAJA Polluste JARNO Habicht RUTtt Kalda | 2006 | International Journal for Quality in Health Care2006，18，6： | 1 |
| 20 | Capillary CAd deposition in kidney allografts: a specific marker of aUoantibody-dependent graft injury显示文摘 | Bohmig GA Exner M Habicht A | 2002 | J Am Sac Nephrol2002，13，4： | 1 |
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