|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review显示文摘Treatment with pharmacological drugs for colorectal cancer(CRC)remains unsatisfactory.A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs,creating an urgent issue.In this review,we summarize previous studies on the resistance of CRC cells to irinotecan and discuss possible reasons for refractoriness.Our review presents the following five major causes of irinotecan resistance in human CRC:(1)cellular irinotecan resistance is induced mainly through the increased expression of the drug efflux transporter,ABCG2;(2)cellular irinotecan resistance is also induced in association with a nuclear receptor,pregnane/steroid X receptor(PXR/SXR),which is enriched in the CYP3A4 gene enhancer region in CRC cells by exposing the cells to SN-38;(3)irinotecan-resistant cells possess either reduced DNA topoisomerase I(Top1)expression at both the mRNA and protein levels or Top1 missense mutations;(4)alterations in the tumor microenvironment lead to drug resistance through intercellular vesicle-mediated transmission of miRNAs;and(5)CRC stem cells are the most difficult targets to successfully treat CRC.In the clinical setting,CRC gradually develops resistance to initially effective irinotecan-based therapy.To solve this problem,several clinical trials,such as irinotecan plus cetuximab vs.cetuximab monotherapy,have been conducted.Another clinical trial on irinotecan plus guadecitabine,a DNA-methyltransferase inhibitor,has also been conducted. | Shogo Ozawa Toshitaka Miura Jun Terashima Wataru Habano | 2021 | Cancer Drug Resistance2021，4，4： | 2 |
| 2 | Correlation of histologic morphology and tumor stage with molecular genetic analysis using microdissection in gastric carcinomas 显示文摘 | Sugai T Habano W Nakamura S | 1998 | Diagn Mol Pathol1998，7，5： | 1 |
| 3 | Analysis of microsatellite alterations in gastric carcinoma using the crypt isolation technique 显示文摘 | Jiao YF Sugai T Habano W | 2004 | J Pathol2004，204，2： | 1 |
| 4 | Genetic alterations in DNA diploid, aneuploid and muhiploid colorectal carcinomas identified by the crypt isolation technique 显示文摘 | Sugai T Habano W Nakamura S | 2000 | Int J Cancer2000，88，4： | 1 |
| 5 | Analysis of genetic alterations associated with DNA diploidy, aneuploidy and multiploidy in gastric cancers显示文摘 | Sugal T Habano W Jiao YF | 2005 | Oncology2005，68，46： | 1 |
| 6 | DNA mapping of gastric cancers using flow cytometric analysis显示文摘 | Sugai T Uesugi N Habano W | 2000 | Cytometry2000，42，5： | 1 |
| 7 | Clinicopathological significance of loss of heterozygosity in intestinal- and solid-type gastric carcinomas: acomprehensive study using the crypt isolation technique显示文摘 | Jiao YF Sugai T Habano W | 2006 | Mod Pathol2006，19，4： | 1 |
| 8 | DNA mapping of gastric cancers using flow cytometric analysis显示文摘 | Uesugi N Habano W | 2000 | Cytometry2000，42，5： | 1 |
| 9 | Analysis of molecular alterations in left- and right-sided colorectal carcinomas reveals distinct pathways of carcinogenesis: proposal for new molecular profile of colorectal carcinomas 显示文摘 | Sugai T Habano W Jiao YF | 2006 | Mol Diagn2006，8，2： | 1 |
| 10 | Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma 显示文摘 | Sugai T Nakamura SI | 2000 | Gastroenterology2000，118，： | 1 |
| 11 | Mitochondrial gene mutation,but not large-scale deletion,is a feature of colorectal carcinomas with mitochondrial microsatellite instability显示文摘 | Habano W Sugai T Yoshida T | 1999 | Int J Cancer1999，83，5： | 1 |
| 12 | Mitochondrial gene mutation,but not large-scale deletion,is a feature of colorectal carcinomas with mitochondrial microsatellite instability显示文摘 | Habano W Sugai T Yoshida T | 1999 | Int J Cancer1999，83，5： | 1 |
| 13 | Microsatellite instability in gallbladder carcinoma:two independent genetic pathways of gallbladder carcinogenesis显示文摘 | Yoshida T Sugai T Habano W | 2000 | J Gastroenterol2000，35，10： | 1 |
| 14 | Microsatellite instability in the mitochondrial DNA of colorectal carcinomas:evidence for mismatch repair systems in mitochondrial genome显示文摘 | Habano W Nakamura S Sugai T | 1998 | Oncogene1998，17，： | 1 |
| 15 | Microsatellite instability in the mitochondrial DNA of colorectal carcinomas:evidence for mismatch repair systems in mitochondrial genome显示文摘 | Habano W Nakamura S Sugai T | 1998 | Oncogene1998，17，15： | 1 |
| 16 | Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma 显示文摘 | Habano W Sugai T Nakamura SI | 2000 | Gastroenterology2000，118，： | 1 |
| 17 | Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: evidence for mismatch repair systems in mitochondrial genome 显示文摘 | Habano W Nakamura S Sugai T | 1998 | Oncogene1998，17，15： | 1 |
| 18 | Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma显示文摘 | Habano W Sugai T Nakamura SI | 2000 | Gastroenterology2000，118，： | 1 |
| 19 | Microsatellite instability and mutation of mitochondrial and nuclear DNA in gastric carcinoma显示文摘 | Habano W Sugai T Nakamura S I | 2000 | Gastroenterology2000，118，5： | 1 |
| 20 | Inhibition of ocular angiogenesis by diced small interfering RNAs (siRNAs) specific to vascular endothelial growth factor (VEGF)显示文摘 | Murata M Takanami T Shimizu S Kubota Y Horiuchi S Habano W | 2006 | Curr Eye Res2006，31，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员