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| 1 | Nutritional care in hospitalized patients with chronic liver disease显示文摘AIM: To evaluate the practice of nutritional assessment and management of hospitalised patients with cirrhosis and the impact of malnutrition on their clinical outcome.METHODS: This was a retrospective cohort study on patients with liver cirrhosis consecutively admitted to the Department of Gastroenterology and Hepatology at the Royal Adelaide Hospital over 24 mo. Details were gathered related to the patients' demographics, disease severity, nutritional status and assessment, biochemistry and clinical outcomes. Nutritional status was assessed by a dietician and determined by subjective global assessment. Estimated energy and protein requirements were calculated by Simple Ratio Method. Intake was estimated from dietary history and/or food charts, and represented as a percentage of estimated daily requirements. Median duration of follow up was 14.9(0-41.4) mo. RESULTS: Of the 231 cirrhotic patients(167 male, age: 56.3 ± 0.9 years, 9% Child-Pugh A, 42% ChildPugh B and 49% Child-Pugh C), 131(57%) had formal nutritional assessment during their admission and 74(56%) were judged to have malnutrition. In-hospitalcaloric(15.6 ± 1.2 kcal/kg vs 23.7 ± 2.3 kcal/kg, P = 0.0003) and protein intake(0.65 ± 0.06 g/kg vs 1.01 ± 0.07 g/kg, P = 0.0003) was significantly reduced in patients with malnutrition. Of the malnourished cohort, 12(16%) received enteral nutrition during hospitalisation and only 6(8%) received ongoing dietetic review and assessment following discharge from hospital. The overall mortality was 51%, and was higher in patients with malnutrition compared to those without(HR = 5.29, 95%CI: 2.31-12.1; P < 0.001). CONCLUSION: Malnutrition is common in hospitalised patients with cirrhosis and is associated with higher mortality. Formal nutritional assessment, however, is inadequate. This highlights the need for meticulous nutritional evaluation and management in these patients. | Dep K Huynh Shane P Selvanderan Hugh AJ Harley Richard H Holloway Nam Q Nguyen | 2015 | World Journal of Gastroenterology2015，21，45： | 6 |
| 2 | The Integrator complex controls the termination of transcription at diverse classes of gene targets显示文摘包含 INTS3 和 NABP1 或 NABP2 的建筑群开始在 DNA 损坏回答被描绘,但是他们的生物化学的功能仍然保持未知。用亲密关系纯化和 HIV 集成定序目标(HIT-Seq ) ,我们发现这些建筑群是综合者建筑群的部分,它绑 RNA 聚合酶 II 并且调整特定的目标基因。综合者作为他们在亲密地被结合的机制处理到他们的成熟形式的部分劈开 snRNAs 抄写结束。然而, HIT-Seq 表明那个综合者也绑在 3 ′以 polyadenylated 抄本复制依赖者 histones 和倡导者结束基因的近似区域。综合者子单元的弄空导致抄写结束失败, histone mRNA 处理的混乱,和 snRNAs 和 histone mRNAs 的 polyadenylation。而且,倡导者综合者的近似绑定否定地通常调整其抄本是的基因的表示 polyadenylated。到所有三个基因类的综合者招募是 DSIF 依赖的,建议那个综合者作为在 DSIF 依赖的 RNA 聚合酶 II 的结束建筑群工作暂停地点。 | Jeffrey R Skaar Andrea L Ferris Xiaolin Wu Anita Saraf Kum Kum Khanna Laurence Florens Michael P Washburn Stephen H Hughes Michele Pagano | 2015 | Cell Research2015，25，3： | 2 |
| 3 | Collocation, Dissipation and for Time Integration Schemes in Struc- tural Dynamics显示文摘 | HILBER H M HUGHES T J R | 1978 | Earthquake Engineering & Structural Dynamics1978，6，1： | 1 |
| 4 | Climate in Medieval time显示文摘 | Bradley R S Hughes M K Diaz H F | 2003 | Science2003，302，： | 1 |
| 5 | Food allergy显示文摘 | SCOTrH H SICHERER M D HUGH A | 2006 | Journal of Allergy and Clinical Immunology2006，117，2： | 1 |
| 6 | Adverse events and near miss reporting in the NHS显示文摘 | Shaw R Drever F Hughes H | 2005 | Qual Saf Health Care2005，14，： | 1 |
| 7 | Anti-TNFalpha therapy improve survival and ameliorate the pathophysiologic sequelae in acute pancreatitis in the rat显示文摘 | HUGHES C B GREWAL H P GAHER L W | 1996 | Am J Sury1996，171，： | 1 |
| 8 | Sediment Fingerprinting in Agricultural Catchments:A Critieal Re-examination of Source Dis- erimination and Data Corrections 显示文摘 | HUGH G S WILLIAM H B | 2014 | Geomorphology2014，204，： | 1 |
| 9 | A preliminary studyof the actuvation of endogenous pancreatic exocrine enzymesduring automated porcine islet isolation 显示文摘 | White SA I^aballah H Hughes DP | 1999 | Cell Transplant1999，8，3： | 1 |
| 10 | Sociology of Education: a Critical History and Prospects for the Future显示文摘 | Lauder Hugh Phillip Brown A H Halsey | 2009 | Oxford Review of Education2009，35，5： | 1 |
| 11 | Extracellular release of carbon by marine phytoplankton: a physiological approach 显示文摘 | Mague T H Friberg E Hughes D J | 1980 | Limnology Oceanography1980，25，： | 1 |
| 12 | Flagellar phase variation in Salmonella enterica is mediated by a posttranscriptional control mechanism显示文摘 | BONIFIELD H R HUGHES K T | 2003 | J Bacteriol2003，185，： | 1 |
| 13 | Prelysis washing improves DNA extraction from a forest soil显示文摘 | He J h Xua Z H Hughes J | 2005 | Soil Biochemistry2005，37，： | 1 |
| 14 | Is there a relation between docosahexaenoic acid concentration in mothers' milk and visual development in term infants? 显示文摘 | Jorgensen M H Hernell O Hughes E | 2001 | J Pediatr Gastroenterol Nutr2001，32，3： | 1 |
| 15 | Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy显示文摘 | Hughes R Bensa S Willison H | 2002 | Ann Neurol2002，50，2： | 1 |
| 16 | A preliminary study of the activation of endogenous pancreatic exocrine enzymes during automated porcine islet isolation显示文摘 | White SA Djaballah H Hughes DP | 1999 | Cell Transplant1999，8，3： | 1 |
| 17 | Climate change, human impacts, and the resilience of coralreefs显示文摘 | HUGHES T P BAIRD A H BELLWOOD D R | 2003 | Science2003，301，： | 1 |
| 18 | Sodium as a toxic ion in potassium deficiency 显示文摘 | CANNON P R FRAZIER L E HUGHES R H | 1953 | Metabolism1953，2，4： | 1 |
| 19 | Anti-TNF alpha therapy improves survival and ameliorates the pathophysiologic sequelae in acute panereatitis in the rat显示文摘 | HUGHS C B GREWAL H P GABER L W | 1996 | Am J Surg1996，171，： | 1 |
| 20 | Culture as a tourist resource: a theoretical consideration 显示文摘 | Hughes H L | 1987 | Tourism Management1987，，8： | 1 |
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