|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | A Hybrid GA/SVM Approach for Gene Selection and Classification of Microarray Data显示文摘 | Huerta E B Duval B Hao J K | 2006 | Lecture Notes in Computer Science2006，3907，： | 1 |
| 3 | Structural Crack De- tection without Updated Baseline Model by Single and Multiobjective Optimization 显示文摘 | Perera R Fang S E Huerta C | 2009 | Mechanical Systems and Signal Processing2009，23，3： | 1 |
| 4 | Electromechanical response of semiconducting carbon-polyimide nanocomposite thin film 显示文摘 | MURUGARAJ P MAINWARING D E MORA- HUERTAS N | 2009 | Compos Sci Teehnol2009，69，14： | 1 |
| 5 | A Hybrid LDA and Genetic Algorithm for Gene Selection and Classification of Microarray Data 显示文摘 | Huerta E B Duval B Hao J K | 2010 | Neurocomputing2010，，73： | 1 |
| 6 | Structure, composition and electrical properties of YSZ films deposited by ultrasonic spray pyrolysis显示文摘 | RAMIREZ E B HUANOSTA A SEBASTIAN J P HUERTA L ORTIZ A ALONSO J C | 2007 | Journal of Materials Science2007，42，3： | 1 |
| 7 | Effect of fixed bed drying on the retention of phenolic compounds, anthocyanins and antioxidant activity of roselle (Hibiscus sabdariffa L) 显示文摘 | Daniel D L Huerta B E B Sosa I A | 2012 | Ind Crop Prod2012，40，： | 1 |
| 8 | A robust pre- dictive current control for three-phase grid-connected inver-ters 显示文摘 | MORENO J C HUERTA J M E GIL R G ct al | 2009 | IEEE Transactions on Industrial Electronics2009，56，6： | 1 |
| 9 | Acquisition of inorganic carbon by the marine haptophyte Isochrysis galbana ( Prymnesiophyceae ) 显示文摘 | Bhatti S Huertas I E Colman B | 2002 | Journal of Pbycology2002，38，5： | 1 |
| 10 | Wastewater reuse and risk:definition of key objectives显示文摘 | Salgot M Huertas E Weber S | 2006 | Desalination2006，187，13： | 1 |
| 11 | A Synchronous Reference Frame Robust Predictive Current Control for Three-Phase Grid-Connected Inverters显示文摘 | Huerta J M E Castello-Moreno J Fischer J R | 2010 | IEEE Transactions on Industrial Electronics2010，57，3： | 1 |
| 12 | Firms' motivations for coop- erative R&D: an empirical analysis of Spanish firms 显示文摘 | BAYONA C MARCO T HUERTA E | 2001 | Research Policy2001，30，8： | 1 |
| 13 | Pneumonie and Nonpneumo-nic Exacerbations of COPD : Inflammatory Response and Clinical Char- acteristics显示文摘 | Huerta A Crisafulli E Men6ndez R | 2013 | Chest2013，144，4： | 1 |
| 14 | Risk factors for intestinal is- chaemia among patients registered in a UK primary care database: a nested case-control study 显示文摘 | Huerta C Rivero E Montoro MA | 2011 | Aliment Pharmacol Ther2011，33，8： | 1 |
| 15 | Molecular marker mapping of leaf rust resistance gene Lr46 and its association with stripe rust resistance gene Yr29 in wheat显示文摘 | William M Singh R P Huerta E J | 2003 | Phytopathology2003，93，2： | 1 |
| 16 | Analysis of a full scale in si- tu test simulating repository conditions 显示文摘 | Gens A Garcia-Molinal A J Olivella S Alonso E E Huertas F | 1998 | Int J Numer Anal Meth Geomech1998，22，7： | 1 |
| 17 | Swine torque teno virus(TTV) infection and excretion dynamics in conventional pig farms显示文摘 | SIBILA M MARTINEZ-GUIN L HUERTA E | 2009 | Vet Microbiol2009，139，3： | 1 |
| 18 | Framing, decision- aid systems, and culture: Exploring influences on fraud investigations 显示文摘 | Huerta E Glandon T Petrides Y | 2012 | International Journal of Accounting Information Systems2012，，13： | 1 |
| 19 | Firms' motivations for cooperative R&D:an empirical analysis of Spanish firms显示文摘 | Bayona C Garcia-Marco T Huerta E | | 0，，08： | 1 |
| 20 | Torque teno virus (TTV)infection in sows and suckling piglets显示文摘 | Sibila M Martinez-Guino L Huerta E | | 0，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员