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| 1 | 亚洲地区肺炎支原体和肺炎衣原体在成人社区获得性肺炎中的流行病学研究显示文摘目的由Malaya大学医学中心牵头进行的非典型病原在亚洲社区获得性肺炎(CAP)患者中的流行病学研究。结果显示,肺炎支原体和肺炎衣原体分别占成人病原的11.4%和5.8%。本研究将对这2种病原所致感染的临床和实验室资料进一步总结分析。方法亚洲7个国家12个研究中心采用统一的检测方法(DNA检测及血清学方法)和判断标准,对16岁以上的CAP患者进行肺炎支原体和肺炎衣原体的检测。结果在急性肺部感染者中,肺炎支原体和肺炎衣原体肺炎的临床表现与其他病原所致者非常相似,并无特征性。肺炎支原体和肺炎衣原体在男性和女性中检出率相仿,但肺炎支原体感染在16至44岁患者中更为多见(22.2%),而肺炎衣原体感染者重症患者相对较多。88例在病程中血清抗体显著增高的肺炎支原体感染者中,48例(54.5%)患者急性期抗体阴性,如果未检测恢复期血清抗体,上述患者则会漏诊;51例肺炎衣原体感染者中急性期血清抗体阴性则较为少见(21.6%)。肺炎支原体和肺炎衣原体既往感染和(或)病原携带率分别为5.7%和7.9%。结论肺炎支原体肺炎和肺炎衣原体肺炎发病率高,诊断困难,因此在亚洲成人CAP抗感染经验治疗时宜选用对这2种病原亦有效的药物。 | 黄海辉 张婴元 汪复 Mediadora SANIEL Marissa ALEJANDRIA Seung-Chul PARK 刘又宁 Po-Ren HSUEH Ahmad M. AZIAH Wing-Hong SETO Cecilia C. L. NGAN Mangunnegoro HADIARTO Subharee SUWANJUTHA Yun-Fong NGEOW Alsagaff HOOD | 2008 | 中国感染与化疗杂志2008，8，2： | 67 |
| 2 | 童年中期同伴关系与孤独感的中介变量检验显示文摘以571名小学三、四、五、六年级的儿童为被试,考察了儿童社会喜好、友谊质量、社交自我知觉与孤独感的关系,检验了社交自我知觉在同伴关系变量与孤独感间的中介作用。结果表明,社会喜好、友谊质量、社交自我知觉和孤独感间相关显著,并且存在显著的性别差异;社交自我知觉在同伴关系变量与孤独感间存在中介的作用;独立的中介效应检验中,社会喜好、友谊质量均通过社交自我知觉的中介作用与孤独感发生联系,同时,也存在直接的联系;综合模型中,社会喜好只通过社交自我知觉的中介作用与孤独感产生联系,不存在直接效应,而友谊质量与孤独感既存在中介的联系,同时也存在直接联系。 | 周宗奎 孙晓军 赵冬梅 Hsueh Yeh | 2005 | 心理学报2005，37，6： | 58 |
| 3 | 小学儿童互选友谊的发展趋势及攻击行为的影响:3年追踪研究显示文摘对小学3、4年级的285名儿童进行了3年追踪调查,分析了儿童分别与男、女生互选友谊数的变化趋势及其在个体间的差异,探讨了外部攻击和关系攻击分别对两类互选友谊数的影响。结果表明:(1)儿童的男、女生互选友谊数在3年时间内都有显著的增加趋势,并表现出显著的性别差异,儿童与同性互选友谊数显著多于他们与异性的互选友谊数,男生与女生互选友谊数的增加速度比女生与女生互选友谊数增加速度慢,儿童与男生的互选友谊数越多,他/她与女生的互选友谊数就越少,表明了性别疏离现象的存在。(2)在控制了关系攻击的影响后,儿童的外部攻击对他们在各时间点测得的与女生的互选友谊数有显著的消极影响,而对他们与男生的互选友谊数影响不显著;在控制了外部攻击的影响后,儿童的关系攻击对他们在各时间点测得的与女生的互选友谊数有显著的积极影响,而对他们与男生的互选友谊数影响不显著。这说明外部攻击和关系攻击对儿童互选友谊数的影响存在性别差异。 | 赵冬梅 周宗奎 孙晓军 Yeh Hsueh Robert Cohen | 2008 | 心理学报2008，40，12： | 21 |
| 4 | Current systemic treatment of hepatocellular carcinoma:A review of the literature显示文摘Hepatocellular carcinoma(HCC) is the fifth most common form of human cancer worldwide and the third most common cause of cancer-related deaths. The strategies of various treatments for HCC depend on the stage of tumor,the status of patient's performance and the reserved hepatic function. The Barcelona Clinic Liver Cancer(BCLC) staging system is currently used most for patients with HCC. For example,for patients with BCLC stage 0(very early stage) and stage A(early stage) HCC,the curable treatment modalities,including resection,transplantation and radiofrequency ablation,are taken into consideration. If the patients are in BCLC stage B(intermediate stage) and stage C(advanced stage) HCC,they may need the palliative transarterial chemoembolization and even the target medication of sorafenib. In addition,symptomatic treatment is always recommended for patients with BCLC stage D(end stage) HCC. In this review,we will attempt to summarize the historical perspective and the current developments of systemic therapies in BCLC stage B and C in HCC. | Kai-Wen Chen Tzu-Ming Ou Chin-Wen Hsu Chi-Ting Horng Ching-Chang Lee Yuh-Yuan Tsai Chi-Chang Tsai Yi-Sheng Liou Chen-Chieh Yang Chao-Wen Hsueh Wu-Hsien Kuo | 2015 | World Journal of Hepatology2015，7，10： | 12 |
| 5 | 小学儿童的尊重观念及其发展显示文摘以开放式尊重观念问卷对小学三到六年级儿童进行集体施测研究儿童的尊重观念,结果发现:(1 )小学儿童认为尊重就是有礼貌,尊重对象的特征和尊重原因都是要求对方品质好或学习好。尊重的对象既有长辈又有同辈,提到尊重同辈的显著多于只尊重长辈的。不同的人际背景下,儿童的尊重观念不一致。(2 )小学儿童的尊重观念具有显著的发展特征,表现出从单向尊重到双向尊重的发展趋势。不同人际关系下的尊重观念的发展特征不同,对父母和老师的尊重主要为单向尊重,对朋友的尊重主要为双向尊重。(3)小学儿童的尊重观念具有显著的性别差异。 | 张春妹 周宗奎 Yeh Hsueh | 2005 | 心理科学2005，28，2： | 10 |
| 6 | 2008-2014年亚太地区腹腔和尿路感染分离的肠杆菌科细菌中产ESBL、AmpC和碳青霉烯酶耐药基因的分子流行病学调查:SMART细菌耐药性监测结果报告显示文摘本研究主要探讨2008-2014年亚太地区腹腔和尿路感染分离的肠杆菌科细菌对常用抗菌药物的敏感性特点及菌株中ESBL、AmpC和碳青霉烯酶等β内酰胺酶耐药基因的分子流行病学特征。 | Jean SS Hsueh PR 沈震 王明贵 | 2017 | 中国感染与化疗杂志2017，17，5： | 9 |
| 7 | Impact of Acupuncture Therapy in Postoperative Aortic Dissection Patients with Cerebral Infarction:A Case Study显示文摘Introduction Aortic dissection is a life-threatening disease that can produce a variety of symptoms and complications.Patients at high risk for mortality,such as individuals with aortic regurgitation,cardiac tamponade,or myocardial infarction,should be treated by surgery as soon as possible,especially in cases with acute ascending aortic dissections(Stanford type A).However,patients with aortic dissection may suffer adverse outcomes that | HSUEH Tun-Pin HUNG Yu-Chiang HU Wen-Long | 2017 | Chinese Journal of Integrative Medicine2017，23，1： | 9 |
| 8 | Innate immune responses regulate morphogenesis and degeneration:roles of Toll-like receptors and Sarm1 in neurons显示文摘The central nervous system is recognized as an immunoprivileged site because peripheral immune cells do not typically enter it.Microglial cells are thought to be the main immune cells in brain.However, recent reports have indicated that neurons express the key players of innate immunity, including Toll-like receptors(TLRs) and their adaptor proteins(Sarm1, Myd88, and Trif), and may produce cytokines in response to pathogen infection.In the absence of an immune challenge, neuronal TLRs can detect intrinsic danger signals and modulate neuronal morphology and function.In this article, we review the recent fi ndings on the involvement of TLRs and Sarm1 in controlling neuronal morphogenesis and neurodegeneration.Abnormal behaviors in TLRand Sarm1-defi cient mice are also discussed. | Hsin-Yu Liu Chiung-Ya Chen Yi-Ping Hsueh | 2014 | Neuroscience Bulletin2014，30，4： | 9 |
| 9 | Treatment of patients with advanced gastrointestinal stromal tumor of small bowel: Implications of imatinib mesylate显示文摘瞄准:检验 imatinib 的影响耐心的幸存和反应和它的安全上的 mesylate (Glivec ) ,和反应的关联与工具包基因变化地位评价。方法:74 中的 33 个(44.6%) 在药品切除术以后并且不开发了复发的胃肠的基质肿瘤(大意) 病人与 Glivec 对待的小肠是被分类组 A 病人。与 Glivec 对待的 22 个先进的小肠大意病人作为组 B 病人被分类。Clinicopathological 特征,复发以后、全面的幸存率被比较。在组 B 病人的每个肿瘤为工具包或导出血小板的生长因素高山的变化被调查哈(PDGFRA ) 。变化类型与临床的结果被相关。在组 B 病人的 Glivec 的反肿瘤效果和安全也被估计。结果:与 Glivec 对待的先进的小肠大意病人比没与 Glivec 对待的那些有 substatntially 更长的复发以后的幸存和更高全面的幸存率。15 个病人的一个总数有部分回答(PR )(67.8%) 。c 工具包的激活的变化在 19 个测试病人中的 16 个被发现,没有 PDGFRA 异种被识别。在有在 11 个工具包变化上怀有前的大意的 13 个病人,部分反应率(PR ) 是 69.3% ,而有在 9 工具包变化上包含前的肿瘤的三个病人中的二个有 66.7% 的全面反应率(ORR )( 不重要) 。结论:Glivec 显著地与先进大意延长亚洲病人的复发以后、全面的幸存。Glivec 导致持续客观回答在多于有先进的小肠大意的亚洲病人的一半。11 上的工具包前的激活的变化在绝大多数大意是可检测的。在 11 个变化上处于为其大意在 9 上有工具包前的病人和前的 PR 率没有差别。 | Chun-Nan Yeh Tsung-Wen Chen Ting-Jung Wu Swei Hsueh Yi-Yin Jan | 2006 | World Journal of Gastroenterology2006，12，23： | 6 |
| 10 | A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure显示文摘5q-syndrome is a distinct form of myelodysplastic syndrome(MDS) where a deletion on chromosome 5 is the underlying cause.MDS is characterized by bone marrow failures,including macrocytic anemia.Genetic mapping and studies using various models support the notion that ribosomal protein S14(RPS14) is the candidate gene for the erythroid failure.Targeted disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal proteins.However,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment option.To better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 gene.This model mirrors the anemic phenotype seen in 5q-syndrome.Moreover,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes p53-dependent.Finally,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,L-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype. | Jason Ear Jessica Hsueh Melinda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra Kathleen M.Sakamoto Shuo Lin | 2016 | Journal of Genetics and Genomics2016，43，5： | 5 |
| 11 | Perioperative topical ascorbic acid for the prevention of phacoemulsification-related corneal endothelial damage:Two case reports and review of literature显示文摘BACKGROUND The current case report describes successful phacoemulsification with the aid of perioperative topical ascorbic acid(AA) in two patients with corneal endothelial disorders to prevent postoperative corneal endothelial decompensation.CASE SUMMARY Two eyes of two patients underwent phacoemulsification with pre-existing corneal endothelial disorders including Fuchs corneal endothelial dystrophy(Patient 1) and endotheliitis(Patient 2). Topical AA was applied to both patients at least one month before and after with a frequency of four times per day. After the surgery, both eyes improved best-corrected visual acuity(BCVA) and there was limited human corneal endothelial cell loss without signs of corneal endothelial decompensation, such as deteriorated BCVA or persistent corneal edema during the follow-up of at least two years.CONCLUSION Perioperative administration of topical AA may be an alternative therapy to the triple procedure in patients expecting to undergo cataract surgery. | Chia-Yi Lee Hung-Ta Chen Yi-Jen Hsueh Hung-Chi Chen Chieh-Cheng Huang Yaa-Jyuhn James Meir Chao-Min Cheng Wei-Chi Wu | 2019 | World Journal of Clinical Cases2019，7，5： | 4 |
| 12 | Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua Open Pool Reactor显示文摘Head and neck(HN)cancer is an endemic disease in Taiwan,China.Locally recurrent HN cancer after full-dose irradia-tion poses a therapeutic challenge,and boron neutron capture therapy(BNCT)may be a solution that could provide durable local control with tolerable toxicity.The Tsing-Hua Open Pool Reactor(THOR)at National Tsing-Hua University in Hsin-Chu,provides a high-quality epithermal neutron source for basic and clinical BNCT research.Our first clinical trial,entitled“A phase I/II trial of boron neutron capture therapy for recurrent head and neck cancer at THOR”,was carried out between 2010 and 2013.A total of 17 patients with 23 recurrent HN tumors who had received high-dose photon irradiation were enrolled in the study.The fructose complex of l-boronophenylalanine was used as a boron carrier,and a two-fraction BNCT treatment regimen at 28-day intervals was used for each patient.Toxicity was acceptable,and although the response rate was high(12/17),re-recurrence within or near the radiation site was common.To obtain better local control,another clinical trial entitled“A phase I/II trial of boron neutron capture therapy combined with image-guided intensity-modulated radiotherapy(IG-IMRT)for locally recurrent HN cancer”was initiated in 2014.The first administration of BNCT was performed according to our previous protocol,and IG-IMRT was initiated 28 days after BNCT.As of May 2017,seven patients have been treated with this combination.The treatment-related toxicity was similar to that previously observed with two BNCT applications.Three patients had a complete response,but locoregional recurrence was the major cause of failure despite initially good responses.Future clinical trials combining BNCT with other local or systemic treatments will be carried out for recurrent HN cancer patients at THOR. | Ling-Wei Wang Yen-Wan Hsueh Liu Fong-In Chou Shiang-Huei Jiang | 2018 | Cancer Communications2018，38，1： | 4 |
| 13 | Neoadjuvant treatment for resectable pancreatic adenocarcinoma显示文摘Pancreatic adenocarcinoma is the fourth leading cause of cancer mortality in the United States in both men and women, with a 5-year survival rate of less than 5%. Surgical resection remains the only curative treatment, but most patients develop systemic recurrence within 2 years of surgery. Adjuvant treatment with chemotherapy or chemoradiotherapy has been shown to improve overall survival, but the delivery of treatment remains problematic with up to 50% of patients not receiving postoperative treatment. Neoadjuvant therapy can provide benefits of eradication of micrometastasis and improved delivery of intended treatment. We have reviewed the findings from completed neoadjuvant clinical trials, and discussed the ongoing studies. Combinational cytotoxic chemotherapy such as fluorouracil, leucovorin, irinotecan, and oxaliplatin and gemcitabine plus nanoparticle albumin-bound(nab)-paclitaxel, active in the metastatic setting, are being studied in the neoadjuvant setting. In addition, novel targeted agents such as inhibitor of immune checkpoint are incorporated with cytotoxic chemotherapy in early-phase clinical trial. Furthermore we have explored the utility of biomarkers which can personalize treatment and select patients for target-driven therapy to improve treatment outcome. The treatment of resectable pancreatic adenocarcinoma requires multidisciplinary approach and novel strategies including innovative trials to make progress. | John Wong Naveenraj L Solomon Chung-Tsen Hsueh | 2016 | World Journal of Clinical Oncology2016，7，1： | 3 |
| 14 | 大学生创造性社会问题解决的结构及其与心理健康的关系显示文摘以分层取样的方式选取541名大学生,采用社会性问题(故事)情境和SCL-90,考察了创造性的社会问题解决的结构及其与心理健康的关系。结果表明,(1)大学生创造性的社会问题解决策略的独创性、流畅性、变通性、适当性、有效性具有良好的内部一致性,通过探索性因素分析可抽取发散思维能力和适宜性两个主因素,累积解释率为89.68%;(2)创造性的社会问题解决与心理健康不存在显著相关;(3)计算机专业在SCL-90上属低分组的学生的发散思维能力显著高于高分组,管理专业学生问题解决总体上显著高于艺术和计算机专业。专业类型在创造性问题解决与心理健康之间具有调节作用,特定专业(如管理专业)的训练更可能改善创造性社会问题解决的策略(包括适宜性和发散思维能力)。 | 谷传华 陈慧丽 Yeh Hsueh | 2010 | 中国特殊教育2010，，12： | 3 |
| 15 | 儿童同伴尊重的发展及社交领导性的影响:三年追踪显示文摘对285名小学三年级和四年级儿童进行了连续三年的追踪调查,分析了儿童同伴尊重发展趋势及其在群体间的差异,探讨了社交领导性在儿童同伴尊重发展中的预测作用。结果表明:(1)童年中后期儿童与同伴之间的获得尊重与表现尊重具有显著增长趋势;(2)三年间女孩的表现尊重均高于男孩但增长速度无差异;女孩的获得尊重增长速度高于男孩;(3)儿童的社交领导性能够显著正向预测儿童同伴尊重的发展趋势。 | 游志麒 范翠英 周宗奎 赵冬梅 田媛 Yeh Hsueh | 2013 | 心理与行为研究2013，11，1： | 3 |
| 16 | Effect of lipopolysaccharide on diarrhea and gastrointestinal transit in mice: Roles of nitric oxide and prostaglandin E_2显示文摘AIM: To investigate the effect of lipopolysaccharide (LPS)on the diarrheogenic activity, gastrointestinal transit (GIT),and intestinal fluid content and the possible role of nitric oxide (NO) and prostaglandin E2 (PGE2) in gastrointestinal functions of endotoxin-treated mice.METHODS: Diarrheogic activity, GIT, and intestinal fluid content as well as nitric oxide and PGE2 products were measured after intraperitoneal administration of LPS in mice.RESULTS: LPS dose-dependently accumulated abundant fluid into the small intestine, induced diarrhea, but decreased the GIT. Both nitric oxide and PGE2 were found to increase in LPS-treated mice. Western blot analysis indicated that LPS significantly induced the protein expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 in mice intestines. Pretreatment with NG-nitro-L-arginine-methyl ester (L-NAME, a non-selective NOS inhibitor) or indomethacin (an inhibitor of prostaglandin synthesis) significantly attenuated the effects of LPS on the diarrheogenic activity and intestine content, but reversed the GIT.CONCLUSION: The present study suggests that the pathogenesis of LPS treatment may mediate the stimulatory effect of LPS on nitric oxide and PGE2 production and NO/prostaglandin pathway may play an important role on gastrointestinal function. | Yu-Chih Liang Hung-Jung Liu Sheng-Hsuan Chen Chun-Chin Chen Liang-Shung Chou Li Hsueh Tsai | 2005 | World Journal of Gastroenterology2005，11，3： | 3 |
| 17 | 儿童状态社会创造性的跨文化研究:基于中美文化的比较显示文摘从中国和美国中部地区选取小学儿童236人,采用状态社会创造性开放问卷和教师领导方式结构式问卷考察了儿童状态社会创造性的文化差异及其与教师领导方式的关系。结果表明:(1)总体上,美国儿童在社会性问题解决中表现出较强的流畅性和变通性等创造性思维品质,但中国儿童表现出较强的适当性、有效性和冒险性等社会适应和人格状态;(2)状态社会创造性总体上存在着国别与年级之间的交互作用,美国的四年级儿童状态社会创造性得分显著高于五年级儿童;(3)教师领导方式的各个维度均不存在显著的预测作用。中美儿童的状态社会创造性既有相似之处又有不同之处。 | 谷传华 张冬静 Yeh Hsueh Xiangen Hu | 2015 | 心理与行为研究2015，13，2： | 2 |
| 18 | The central role of fat and effect of peroxisome proliferator- activated receptor-gamma on progression of insulin resistance and cardiovascular disease显示文摘 | Hsueh W A Law R | 2003 | Am J Cardiol2003，92，4： | 2 |
| 19 | MULTIPHOTON MICROSCOPY:A NEW APPROACH IN PHYSIOLOGICAL STUDIES AND PATHOLOGICAL DIAGNOSIS FOR OPHTHALMOLOGY显示文摘Multiphoton microscopy(MPM),with the advantages of improved penetration depth,decreased photo-damage,and optical sectioning capability,has become an indispensable tool for biomedical imaging.The combination of multiphoton fluorescence(MF)and second-harmonic generation(SHG)microscopy is particularly effective in imaging tissue structures of the ocular surface.This work is intended to be a review of advances that MPM has made in ophthalmic imaging.The MPM not only can be used for the label-free imaging of ocular structures,it can also be applied for investigating the morphological alterations in corneal pathologies,such as keratoconus,infected keratitis,and corneal scar.Furthermore,the corneal wound healing process after refractive surgical procedures such as conductive keratoplasty(CK)can also be studied with MPM.Finally,qualitative and quantitative SHG microscopy is effective for characterizing corneal thermal denaturation.With additional development,multiphoton imaging has the potential to be developed into an effective imaging technique for in vivo studies and clinical diagnosis in ophthalmology. | CHIU-MEI HSUEH WEN LO SUNG-JAN LIN TSUNG-JEN WANG FUNG-RUNG HU HSIN-YUAN TAN CHEN-YUAN DONG | 2009 | Journal of Innovative Optical Health Sciences2009，2，1： | 2 |
| 20 | Chronic care model in the diabetes pay-for-performance program in Taiwan:Benefits,challenges and future directions显示文摘In this review,we discuss the chronic care model(CCM)in relation to the diabetes pay-for-performance(P4P)program in Taiwan.We first introduce the 6 components of the CCM and provide a detailed description of each of the activities in the P4P program implemented in Taiwan,mapping them onto the 6 components of the CCM.For each CCM component,the following three topics are described:the definition of the CCM component,the general activities implemented related to this component,and practical and empirical practices based on hospital or local government cases.We then conclude by describing the possible successful features of this P4P program and its challenges and future directions.We conclude that the successful characteristics of this P4P program in Taiwan include its focus on extrinsic and intrinsic incentives(i.e.,shared care network),physician-led P4P and the implementation of activities based on the CCM components.However,due to the low rate of P4P program coverage,approximately 50%of patients with diabetes cannot enjoy the benefits of CCMrelated activities or receive necessary examinations.In addition,most of these CCM-related activities are not allotted an adequate amount of incentives,and these activities are mainly implemented in hospitals,which compared with primary care providers,are unable to execute these activities flexibly.All of these issues,as well as insufficient implementation of the e-CCM model,could hinder the advanced improvement of diabetes care in Taiwan. | Tsung-Tai Chen Brian Oldenburg Ya-Seng Hsueh | 2021 | World Journal of Diabetes2021，12，5： | 2 |
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