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| 1 | Handgrip strength and health outcomes: Umbrella review of systematic reviews with meta-analyses of observational studies显示文摘Purpose:The aim of the present study was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies on handgrip strength and health outcomes.Methods:An umbrella review of systematic reviews with meta-analyses of observational studies was conducted.We assessed meta-analyses of observational studies based on random-effect summary effect sizes and their p values,95%prediction intervals,heterogeneity,small-study effects,and excess significance.We graded the evidence from convincing(Class I)to weak(Class IV).Results:From 504 articles returned in a search of the literature,8 systematic reviews were included in our review,with a total of 11 outcomes.Overall,nine of the 11 of the outcomes reported nominally significant summary results(p<0.05),with 4 associations surviving the application of the more stringent p value(p<106).No outcome presented convincing evidence.Three associations showed Class II evidence(i.e.,highly suggestive):(1)higher handgrip values at baseline were associated with a minor reduction in mortality risk in the general population(n=34 studies;sample size=1,855,817;relative risk=0.72,95%confidence interval(95%CI):0.670.78),(2)cardiovascular death risk in mixed populations(n=15 studies;relative risk=0.84,95%CI:0.780.91),and(3)incidence of disability(n=7 studies;relative risk=0.76,95%CI:0.660.87).Conclusion:The present results show that handgrip strength is a useful indicator for general health status and specifically for early all-cause and cardiovascular mortality,as well as disability.To further inform intervention strategies,future research is now required to fully understand mechanisms linking handgrip strength scores to these health outcomes. | Pinar Soysal Christopher Hurst Jacopo Demurtas Joseph Firth Reuben Howden Lin Yang Mark A.Tully Ai Koyanagi Petre Cristian Ilie Guillermo F.Lopez-Sanchez Lukas Schwingshackl Nicola Veronese Lee Smith | 2021 | Journal of Sport and Health Science2021，10，3： | 5 |
| 2 | Is There a Metabolic Requirement for Photorespiratory Enzyme Activities in Heterotrophic Tissues?显示文摘Dear Editor, Photorespiration is an essential metabolic process in leaves that facilitates recovery of carbon lost by the oxygenase reaction of Rubisco and avoids the accumulation of the toxic product,2-phosphoglycolate (2PG) of this reaction (Bauwe et al.,2012).However,there is also evidence to suggest that photorespiration has a more complex role during normal growth than the mere detoxification of 2PG and the recovery of 3-phosphoglycerate (3PGA) (Bauwe et al.,2012).The current view is that photorespiration is an essential mechanism to maintain optimal photosynthesis,normal growth,and development of oxygenic photosynthetic organisms in an oxygen-containing environment (Bauwe et al.,2012). | Adriano Nunes-Nesi Alexandra Florian Andrew Howden Kathrin Jahnke Stefan Timm Hermann Bauwe Lee Sweetlove Alisdair R. Fernie | 2014 | Molecular Plant2014，7，1： | 3 |
| 3 | Effect and feasibility of wearable physical activity trackers and pedometers for increasing physical activity and improving health outcomes in cancer survivors:A systematic review and meta-analysis显示文摘Purpose:This systematic review and meta-analysis aimed to evaluate the effect of wearable devices for improving physical activity and healthrelated outcomes in cancer survivors.Methods:CINAHL,Cochrane,Ebscohost,MEDLINE,Pubmed,ProQuest Health and Medical Complete,ProQuest Nursing and Allied Health Source,ScienceDirect,and SPORTDiscus databases were searched for randomized controlled trials published before September 1,2020,that evaluated interventions involving wearable devices in cancer survivors.Standardized mean differences(SMDs)were calculated to assess effects on physical activity and health-related outcomes.Subgroup analyses were conducted to assess whether the effects differed by interventions and cancer characteristics.Risk of bias was assessed using the Cochrane risk of bias tool.Results:Thirty-five trials were included(breast cancer,n=15,43%).Intervention durations ranged between 4 weeks and 1 year.Most trials(n=25,71%)involved pedometer-based physical activity interventions.Seven(20%)involved Fitbit-based interventions,and 3(9%)involved other wearable physical activity trackers(e.g.,Polar,Garmin).Compared to usual care,wearable devices had moderate-to-large effects(SMD range 0.54-0.87,p<0.001)on moderate-intensity physical activity,moderate-to-vigorous-intensity physical activity,total physical activity,and daily steps.Compared to usual care,those in the intervention had higher quality of life,aerobic fitness,physical function,and reduced fatigue(SMD range=0.18-0.66,all p<0.05).Conclusion:Wearable physical activity trackers and pedometers are effective tools that increase physical activity and improve health-related outcomes in individuals with cancer.Identifying how these devices can be implemented for longer-term use with other intervention components remains an area for future research. | Benjamin Singh Eva M.Zopf Erin J Howden | 2022 | Journal of Sport and Health Science2022，11，2： | 2 |
| 4 | Recent Safety Concerns With Proton Pump Inhibitors显示文摘 | Joan Chen Yuhong Cathy Yuan Grigorios I. Leontiadis Colin W. Howden | 2012 | Journal of Clinical Gastroenterology2012，，2： | 2 |
| 5 | Phytochelatin synthase genes from Arabidopsis and the yeast Schiz- osaccharomyces pombe显示文摘 | Ha S B Smith A P Howden R | 1999 | Plant Cell1999，11，6： | 1 |
| 6 | Management of acid-related disorders in patients with dysphagia 显示文摘 | Howden CW | 2004 | Am J Med2004，117，： | 1 |
| 7 | Twenty-four-hour intragastric pH: tolerance within 5 days of continuous ranitidine administration 显示文摘 | Lachman L Howden CW | 2000 | Am J Gastroenterol2000，95，1： | 1 |
| 8 | Management of acid-related disorders in patientswith dysphagia显示文摘 | Howden CW | 2004 | Am J Med2004，117，8： | 1 |
| 9 | Isolates with low-level vancomycin resistance associated with persistent methicillin- resistant Staphylococcus aureus bacteremia显示文摘 | Howden BP Johnson PD Ward PB | 2006 | Antimicrob Agents Chemother2006，50，： | 1 |
| 10 | An experimental model for assessment of renal recovery from warm ischemia显示文摘 | Jablonskl P Howden BO Rae DA | 1983 | Transplantation1983，35，3： | 1 |
| 11 | Nri2 and cardiovascular defense 显示文摘 | Howden R | 2013 | Oxid Med Cell Longev2013，2013，10： | 1 |
| 12 | Meta analysis of randomized controlled trials of endoscopic retrograde cholangiopancreatog-raphy and endoscopic sphincterotomy for the treatment of acute biliary pancreatitis显示文摘 | SHARMA V Howden CW | | 0，，： | 1 |
| 13 | Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome显示文摘 | Petrol G Nanda A Howden J Takeichi T McMillan J R Aristodemou S | 2014 | Am J Hum Genet2014，95，： | 1 |
| 14 | Systematic review and meta -analysis of proton pump inhibitor therapy in peptic ulcer bleeding 显示文摘 | Leontiadis GI Sharma VK Howden CW | 2005 | BMJ2005，330，7491： | 1 |
| 15 | Annual rossby wave in the Southern Indian Ocean : Why does it 'Appear' to break down in the Middle Ocean 显示文摘 | WANG L KOBLINSKY C HOWDEN S | 2001 | Journal of Physical Oceanogra- phy2001，31，1： | 1 |
| 16 | Vancomycin in the treatment of methicillin- resistant Staphylococcus aureus - a clinician's guide to the science informing current practice显示文摘 | Lee JY Howden BP | 2015 | Expert Rev Anti Infect Therapy2015，13，7： | 1 |
| 17 | Primary care physician perceptions of non-steroidal anti-inflammatory drug and aspirinassociated toxicity:results of a national survey显示文摘 | Chey WD Eswaren S Howden CW | 2006 | Aliment Pharmacol Ther2006，23，4： | 1 |
| 18 | Omeprezole (20 rag) daily given in the morning or evening: a comparison of effects on gastric acidity, and plasma gastrin and omeprezole concentration 显示文摘 | Chiverton SG Howden CW Burget DW | 1992 | Aliment Pharmacol Ther1992，6，： | 1 |
| 19 | Appropriate ac-id supperssion for the management of gastro-esophag-eal reflux disease显示文摘 | Bell NJV Burget D Howden CW | 1992 | Digestion1992，51，： | 1 |
| 20 | Crop and pasture response to climate change 显示文摘 | Tubiello F Soussana J Howden S | 2007 | Proceedings of the National Academy of Sci- ences2007，104，19： | 1 |
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