|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment of meniscal tears: An evidence based approach显示文摘Treatment options for meniscal tears fall into three broad categories;non-operative,meniscectomy or meniscal repair.Selecting the most appropriate treatment for a given patient involves both patient factors(e.g.,age,co-morbidities and compliance)and tear characteristics(e.g.,location of tear/age/reducibility of tear).There is evidence suggesting that degenerative tears in older patients without mechanical symptoms can be effectively treated non-operatively with a structured physical therapy programme as a first line.Even if these patients later require meniscectomy they will still achieve similar functional outcomes than if they had initially been treated surgically.Partial meniscectomy is suitable for symptomatic tears not amenable to repair,and can still preserve meniscal function especially when the peripheral meniscal rim is intact.Meniscal repair shows 80%success at 2 years and is more suitable in younger patients with reducible tears that are peripheral(e.g.,nearer the capsular attachment)and horizontal or longitudinal in nature.However,careful patient selection and repair technique is required with good compliance to post-operative rehabilitation,which often consists of bracing and non-weight bearing for 4-6 wk. | Simon C Mordecai Nawfal Al-Hadithy Howard E Ware Chinmay M Gupte | 2014 | World Journal of Orthopedics2014，5，3： | 18 |
| 2 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 3 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 4 | Prospective and long-term evaluation of erect penile length obtained with inflatable penile prosthesis to that induced by intracavernosal injection显示文摘在有那的可膨胀的阴茎修复术(IPP ) 培植在外科前由 in-tracavernosal 注射(帝国化学工业公司) 导致了以后,我们比较了直立的阴茎长度。有充分勃起的 11 个病人的一个总数在阴茎颜色的时候由 Trimix (papaverine, phentolamine 和前列腺素 E1 ) 的 0.25 mL 的帝国化学工业公司导致了双 Doppler ultrasonography 在这研究被注册。病人随后为他们的可勃起的机能障碍(编辑) 作为最终的治疗经历了 IPP 培植。对 IPP 培植作为结果的直立的阴茎长度在 6 个星期被测量, 6 个月并且在在外科以后的 1 年。为男人(填隙用木片) 的性健康库存在 IPP 培植以后被管理在前,并且在 6 个月和 1 年。是导致了由树立阴茎长度(吝啬的 s.e ) 而与 IPP 达到的长度是 12.4,帝国化学工业公司是 13.2 0.4 厘米 0.3,在第六个星期,第六个月和 1 年的后续的 12.5 0.3 和 12.5 0.4 厘米分别地。有 0.83 0.25,分别地, 0.75 0.20 和 0.74 0.15 厘米在 IPP 培植以后在 6 个星期, 6 个月和 1 年在直立的阴茎长度减少什么时候与那相比在帝国化学工业公司以后(P < 0.05 ) 。没有抱怨,为报导更短的阴茎的病人的填隙用木片分数与为病人的那些一样(P > 0.05 ) 。到我们的知识,这是第一研究客观地在 IPP 培植以后在直立的阴茎长度看重要减少是否与那相比在帝国化学工业公司以后。然而,这减少没在对待编辑影响 IPP 的有效性。 | Run Wang Galen E Howard Anthony Hoang Jiu-Hong Yuan Hao-Cheng Lin Yu-Tian Dai | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 5 | Association of types of diabetes and insulin dependency on birth outcomes显示文摘BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes status.METHODS Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant mortality.Confounders included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm birth.Bivariate and multivariate logistic regression assessed differences in outcomes by diabetes status.RESULTS Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic women.Women with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic women.CONCLUSION Diabetes is associated with the poor birth outcomes.Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes. | Pamela K Xaverius Steven W Howard Deborah Kiel Jerry E Thurman Ethan Wankum Catherine Carter Clairy Fang Romi Carriere | 2022 | World Journal of Clinical Cases2022，10，7： | 2 |
| 6 | Improved Technique for the Routine Determination of Tritiated Water in Aqueous Samples显示文摘 | Warwick P E Croudace I W Howard A G | 1999 | Anal Chim Acta1999，382，： | 2 |
| 7 | NF-kappa B is Activated and ICAM-1 Gene Expression is Upregulated During Reoxygenation of Human Brain Endothelial Cells显示文摘 | Howard E Chen O Cheng C | 2004 | Neurosci Lett(S0304-3940)2004，248，3： | 1 |
| 8 | NF-κB is activated and ICAM-1 gene expression is upregulated during reoxygenation of human brain endothelial cells显示文摘 | Howard E F Chen Q Cheng C | 1998 | Neurosci Lett1998，248，3： | 1 |
| 9 | Prognostic significance of visit-to- visit variability, maximum systolic blood pressure, and episodic hypertension 显示文摘 | Rothwell PM Howard SC Dolan E | 2010 | Lancet2010，375，9718： | 1 |
| 10 | IL-10 is critical in tile regula- tion of autoimmune encephalomyelitis as demonstrated by studies of IL- 10- and IL-4-deficient and transgenic mice 显示文摘 | Bettelli E Das MP Howard ED | 1998 | Immunol1998，161，7： | 1 |
| 11 | Prognostic significance of visit- to- visit variability, maximum systolic blood pressure, and epi- sodic hypertension显示文摘 | Rothwel PM Howard SC Dolan E | 2010 | Lancet2010，375，9718： | 1 |
| 12 | Hypertonie marmitol loading of NF- kappaB transcription factor decoys in human brain microvascular endothelial cells blocks upregulation of ICAM - 1 显示文摘 | Hess DC Howard E Cheng C | 2000 | Stroke2000，31，5： | 1 |
| 13 | Wound healing dressings and drug delivery systems: A review显示文摘 | Joshua S B Kerr H M Howard N E S | 2008 | J Pharma- ceutical Sci2008，97，8： | 1 |
| 14 | Abundant and diverse bacteria involved in DMSP degradation in marine surface waters显示文摘 | HOWARD E C SUN S BIERS E J | 2008 | En- vironmental Microbiology2008，10，9： | 1 |
| 15 | Direct observation of behaviour of Au nanoclusters on TiO2(110) at elevated temperatures显示文摘 | MITCHELL C E J HOWARD A CARGEN M EGDLL R G | 2001 | Surface Science2001，490，： | 1 |
| 16 | Hypertonic Mannitol Loading of NF-kB Transcription Factor Decoys in Human Brain Microvascular Endothelial Cells Blocks Upregulation of ICAM-1显示文摘 | Hess DC Howard E Cheng C | 2005 | Stroke(S0039-2499)2005，31，5： | 1 |
| 17 | Side Chain Bromination Isomers of Diosgenin and Tigogenin显示文摘 | MONROE E W HOWARD W J | 1956 | J Am Chem Soc1956，79，： | 1 |
| 18 | Effects of beta blockers and calci- um-channel blockers on within-individual variability in blood pressure and risk of stroke显示文摘 | Rothwell PM Howard SC Dolan E | 2010 | Lancet Neural2010，9，5： | 1 |
| 19 | Effects of 15blockers and calcium- channel blockers on within - individual variability in blood pressure and risk of stroke 显示文摘 | Rothwell PM Howard SC Dolan E | 2010 | Lancet2010，375，9718： | 1 |
| 20 | Methanol conversion for the production of hydrogen 显示文摘 | Taylor C E Howard B H Myers C R | 2007 | Industrial & Engineering Chemistry Research2007，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员