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| 1 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 2 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 3 | Pulmonary hypertensive crises following surgery for congenital heart defects in young children 显示文摘 | Hopkins R A Bull C Haworth S G | 1991 | Eur J Cardiothorac Surg1991，5，12： | 1 |
| 4 | Changes in the content and fatty acid composition of lipid in an isolated population of capelin Malotus villosus during sexual maturation and spawning显示文摘 | Henderson R J Sargent J R Hopkins C E E | 1984 | Mar Biol1984，78，： | 1 |
| 5 | Charaetefization of reservoir lithologies within subunconformity pools : Pekisko formation, Medicine River field, Alberta Canada显示文摘 | Hopkins J C | 1999 | AAPG Bulletin1999，83，11： | 1 |
| 6 | Seed transmission of Acidovorax avenae subsp, c itrulli in cucurbits显示文摘 | Hopkins D L Thompson C M | 2002 | HortScience2002，37，6： | 1 |
| 7 | Direct injection of 90Y Mo Abs into glioma tumor resection cavities leads to limited diffusion of the radioimmunoconjugates into normal brain parenchyma:a model to estimate absorbed radiation dose显示文摘 | Hopkins K Chandler C Eatough J | 1998 | Int J Radiat Oncol Biol Phys1998，40，4： | 1 |
| 8 | A content analy- sis of the comprehensive income exposure draft comment letters 显示文摘 | Yen A C Eric Hirst D Hopkins P E | 2007 | Research in Accounting Regulation2007，19，： | 1 |
| 9 | Extended Aromatic Furan Amidino Derivatives as Anti-Pneumocystis carinii Agents显示文摘 | HOPKINS K T WILSON W D BENDER B C | | 0，，： | 1 |
| 10 | The biochemical andphysical effects of Effect of electrical stimulation on beef andsheep meat tendemess显示文摘 | Hwang I H Devine C E Hopkins D L | 2003 | Meat Science2003，65，： | 1 |
| 11 | The Lund-Mackay staging system for chronic rhinosinusitis: how is it used and what does it predict 显示文摘 | Hopkins C Browne JP Slack R | 2007 | Otolaryngol Head Neck Surg2007，137，4： | 1 |
| 12 | The druggable genome显示文摘 | Hopkins A L Groom C R | 2002 | Nature Reviews Drug Discovery2002，1，9： | 1 |
| 13 | Variation in culture and rDNA among isolates of Sphaeropsis sapinea from Ontario and Manitoba 显示文摘 | Hausner G Hopkin A A Davis C N | 1999 | Canadian journal of plant Pathology1999，21，3： | 1 |
| 14 | Pulmonary hypertensive crises following surgery for congenital heart defects in young children 显示文摘 | Hopkins RA Bull C Haworth SG | 1991 | Eur J Cardiothorac Surg1991，5，12： | 1 |
| 15 | Regulation of senescence by eukaryotic translation initiation factor 5A: Implications for plant growth and development显示文摘 | Thompson J E Hopkins M T Taylor C | 2004 | Trends in Plant Science2004，9，4： | 1 |
| 16 | Acute ischaemic stroke and infection:recent and emerging concepts显示文摘 | EMSLEY H C HOPKINS S J | | 0，，04： | 1 |
| 17 | An evaluation of pharmacists' OTC drug consultations显示文摘 | Nykamp D Hopkins W | 1992 | Pharm Mkt Mgt1992，6，： | 1 |
| 18 | Psychologic morbidities prior to loop electrosurgical excision procecdure in the treatment of cervical in- traepithelial neoplasis 显示文摘 | Le T Hopkins L Menard C | 2006 | Int J Gynecol Cancer2006，16，3： | 1 |
| 19 | Genetic diversity among elite sorghum inbred lines assessed with simple sequence repeats 显示文摘 | SMITH J S C KRESOVICH S HOPKINS M S | 2000 | CROP SIC2000，40，： | 1 |
| 20 | Assessment of right ventricular function using two-jimensional echocardiography显示文摘 | Kaul S Tei C Hopkins JM | 1984 | Am Heart J1984，107，3： | 1 |
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