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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in hepatocellular carcinoma cells显示文摘 | Hopfner M Huether A Sutter AP | 2006 | Biochem Pharmacol2006，71，10： | 1 |
| 3 | A novel approach in the treatment of neuroendocrine gastrointestinal tumors,Targeting the epidermal growth factor receptor by gefitinib (ZD 1893)显示文摘 | Hopfner M Sutter AP Gerst B | 2003 | Br J Cancer2003，89，9： | 1 |
| 4 | A novel approach in the treatment of neuroendocrine gastrointestinal tumors:additive antiproliferative effects of interferon-gamma and meta-iodobenzy L guanidine显示文摘 | Hopfner M Sutter AP Huether A | 2004 | BMC Cancer2004，4，1： | 1 |
| 5 | Overexpression of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression 显示文摘 | Hopfner R Mousli M Oudet P | 2002 | Anticancer Res2002，22，6： | 1 |
| 6 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem pharmacol2005，70，11： | 1 |
| 7 | EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular cancer显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem Pharmacol2005，70，11： | 1 |
| 8 | Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y2-receptors显示文摘 | Maaser K Hopfner M Kap H | 2002 | Br J Cancer2002，86，4： | 1 |
| 9 | Growth inhibition and apoptosis induced by P2Y2 receptors in human colorectal carcinoma cells:involvement of intracellular calcium and cyclic adenosine monophosphate显示文摘 | Hopfner M Maaser K Barthel B | 2001 | Int J Colorectal Dis2001，16，3： | 1 |
| 10 | Structural mechanism of cytosolic DNA sensing by cGAS显示文摘 | Civril F Deimling T de Oliveira M C C Ablasser A Moldt M Witte G Hornung V Hopfner K P | 2013 | Nature2013，498，7454： | 1 |
| 11 | The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle显示文摘 | Jeanblanc M Mousli M Hopfner R | 2005 | Oncogene2005，24，49： | 1 |
| 12 | Extracellular nucleotides inhibit growth of human oesophageal cancer cells via P2Y2 receptors显示文摘 | Maaser K Hopfner M Kap H Sutter AP Barthel B von Lampe B | 2002 | Br J Cancer2002，86，4： | 1 |
| 13 | Overexpressiqn of ICBP90, a novel CCAAT-binding protein, overcomes cell contact inhibition by forcing topoisomerase II alpha expression 显示文摘 | Hopfner R Mousli M Oudet P | 2002 | AnticancerRes2002，22，6： | 1 |
| 14 | ICBP90 belongs to a new family of proteins with an expression that is dereg- ulated in cancer cells显示文摘 | Mousli M Hopfner R Abbady A | 2003 | Brit J Cancer2003，89，1： | 1 |
| 15 | Extracellular nucleotides inhibit growth of hu man oesophageal cancer cells via P2Y ( 2 )-receptors 显示文摘 | Maaser K Hopfner M Kap H Sutter A P Barthel B yon Lampe B | 2002 | Br J Cancer2002，86，： | 1 |
| 16 | Unimolecular elec- trical rectification in hexadecylquinolinium tricyanoquinodimeth- anide 显示文摘 | METZGER R M CHEN B HOPFNER U | 1997 | J Am Chem Soc1997，119，10： | 1 |
| 17 | ICBP90,a novel human CCAAT binding protein,involved in the regulation of topoisomerase Ⅱ expression显示文摘 | Hopfner R Mousli M Jeltsch JM | 2000 | Cancer Res2000，60，1： | 1 |
| 18 | ICBP9O belongs to a new family of proteins with an expression that is deregulated in cancer cells显示文摘 | Mousli M Hopfner R Abbady AQ | 2003 | Br J Cancer2003，89，1： | 1 |
| 19 | EGFR blockade by eetuximab alone or as combination therapy for growth control of hepatocellular eaneer 显示文摘 | Huether A Hopfner M Baradari V | 2005 | Biochem Pharmaeol2005，70，11： | 1 |
| 20 | Blockade of IGF-Ⅰreceptor tyrosine kinase has antineoplastic effects inhepatocellular carcinoma cells显示文摘 | Hopfner M Huether A Sutter AP | 2006 | Biochem Pharmacol2006，71，10： | 1 |
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