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| 1 | Linked multicontinuum and crack tensor approach for modeling of coupled geomechanics, fluid flow and transport in fractured rock显示文摘In this paper, we present a linked multicontinuum and crack tensor approach for modeling of coupled geomechanics, fluid flow, and solute transport in fractured rock. We used the crack tensor approach to calculate effective block-scale properties, including anisotropic permeability and elastic tensors, as well as multicontinuum properties relevant to fracture-matrix interactions and matrix diffusion. In the modeling, we considered stress dependent properties, through stress-induced changes in fracture apertures, to update permeability and elastic tensors. We evaluated the effectiveness and accuracy of our multicon-tinuum approach by comparing our modeling results with that of three independent discrete fracture network (DFN) models. In two of the three alternative DFN models, solute transport was simulated by particle tracking, an approach very different from the standard solute transport used in our multicon-tinuum modeling. We compared the results for flow and solute transport through a 20 m × 20 m model domain of fractured rock, including detailed comparison of total flow rate, its distribution, and solute breakthrough curves. In our modeling, we divided the 20 m × 20 m model domain into regular blocks, or continuum elements. We selected a model discretization of 40 × 40 elements (having a side length of 0.5 m) that resulted in a fluid-flow rate equivalent to that of the DFN models. Our simulation results were in reasonably good agreement with the alternative DFN models, for both advective dominated transport (under high hydraulic gradient) and matrix-diffusion retarded transport (under low hydraulic gradient). However, we found pronounced numerical dispersion when using larger grid blocks, a problem that could be remediated by the use of a finer numerical grid resolution, while maintaining a larger grid for evaluation of equivalent properties, i.e. a property grid overlapping the numerical grid. Finally, we encountered some difficulties in using our approach when element sizes were so small that only one or a few fractures intersect an element-this is an area of possible improvement that will be pursued in future research. | Jonny Rutqvist Colin Leung Andrew Hoch Yuan Wang Zhen Wang | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，1： | 6 |
| 2 | 硫化氢对氢化丁腈橡胶性能的影响显示文摘就硫化氢与丁腈橡胶和氢化丁腈橡胶的不饱和双键,以及与丙烯腈侧基的老化反应的机理作了介绍。研究表明:氢化丁腈橡胶具有优异的耐硫化氢性能,适合用来生产石油钻探领域的相关橡胶制品。 | 张文禹 Martin Hoch | 2015 | 世界橡胶工业2015，42，1： | 6 |
| 3 | Impact of stress on solute transport in a fracture network: A comparison study显示文摘This paper compares numerical modeling of the effect of stress on solute transport (advection and matrix diffusion) in fractured rocks in which fracture apertures are correlated with fracture lengths. It is mainly motivated by the performance and safety assessments of underground radioactive waste repositories. Five research teams used different approaches to model stress/deformation, flow and transport processes, based on either discrete fracture network or equivalent continuum models. The simulation results derived by various teams generally demonstrated that rock stresses could significantly influence solute transport processes through stress-induced changes in fracture apertures and associated changes in permeability. Reasonably good agreement was achieved regarding advection and matrix diffusion given the same fracture network, while some observed discrepancies could be explained by different mechanical or transport modeling approaches. | Zhihong Zhao Jonny Rutqvist Colin Leung Milan Hokr Quansheng Liu Ivars Neretnieks Andrew Hoch Jirí Havlíek Yuan Wang Zhen Wang Yuexiu Wu Robert Zimmerman | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，2： | 6 |
| 4 | 溶胀法和粘度法测定氢化丁腈橡胶的溶解度参数显示文摘利用溶胀法和粘度法测定氢化丁腈橡胶(HNBR)的溶解度参数,并与理论计算值进行比较。结果表明:溶胀法与粘度法测定的HNBR溶解度参数稍有不同,且略小于理论计算值;溶解度参数在19~22(J.cm-3)1/2范围内的溶剂可以有效地溶胀或溶解HNBR;合适的混合溶剂也可以达到单一溶剂的效果。 | 刘广永 刘广革 刘苏苏 邱桂学 Martin Hoch | 2013 | 橡胶工业2013，60，7： | 5 |
| 5 | 溶胀法测定丁基橡胶及卤化丁基橡胶的一维溶度参数显示文摘采用溶胀法测定了丁基橡胶(IIR)、氯化丁基橡胶(CIIR)和溴化丁基橡胶(BIIR)的一维溶度参数(δ),通过Flory–Rehner方程和交联点之间的平均摩尔质量计算了橡胶与溶剂的相互作用参数χ。结果表明,IIR、CIIR、BIIR的δ值相差不大,分别约为17.0,16.5,17.5 MPa1/2;IIR与烃类非极性溶剂的χ略大于CIIR及BIIR与相应溶剂的χ,环己烷和四氯化碳是这3种橡胶的良溶剂。 | 李晓鹏 刘广永 赵树高 Martin Hoch | 2014 | 合成橡胶工业2014，37，6： | 4 |
| 6 | 交联密度对丁苯橡胶与溶剂Flory-Huggins相互作用参数的影响显示文摘研究丁苯橡胶(SBR)的交联密度对SBR与溶剂Flory-Huggins相互作用参数的影响。改变硫黄用量制备了不同交联密度的SBR试样,并采用管道模型计算出交联点间平均相对分子质量,结合平衡溶胀法测得SBR在甲苯、环己烷和乙酸乙酯中溶胀后的体积分数,使用Flory-Rehner方程得到SBR与溶剂的相互作用参数。结果表明:SBR与溶剂的相互作用参数与SBR的体积分数呈线性关系,但溶剂不同,关系式不同。对平衡溶胀法测定交联点的平均相对分子质量的Flory-Rehner方程提出了一个修正式。 | 李晓鹏 谭珊 谢彪 刘广永 赵树高 Martin Hoch | 2016 | 橡胶工业2016，63，3： | 3 |
| 7 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 8 | 硅烷交联三元乙丙橡胶的制备与应用研究进展显示文摘介绍硅烷交联三元乙丙橡胶(EPDM)的交联机理、制备方法、交联影响因素、性能表征和应用前景。EPDM的硅烷交联分为硅烷接枝和交联两个阶段,硅烷交联EPDM的制备方法目前主要为两步法和一步法。配方因素、接枝反应温度和时间以及水浴交联温度和时间对硅烷交联EPDM的接枝反应、水解交联反应和性能的影响较大,硅烷交联EPDM的生产工艺目前仍存在较多问题,硅烷交联EPDM的应用研究需要进一步扩展。 | 林正伟 Martin Hoch 史新妍 | 2021 | 橡胶工业2021，68，6： | 3 |
| 9 | Numerical and experimental investigation of sloshing under large amplitude roll excitation显示文摘To enable a virtual design and optimization process of partially filled coolant tanks a reliable numerical approach is needed to predict the liquid and gas two phase flow inside the tanks.In this study numerical results are validated by experimental data to examine the suitability of the method for the tank design process.The liquid motion inside the tanks can be described as sloshing with high amplitude,off-resonant roll excitation and was examined using a homogeneous multiphase model and VOF interface capturing approach as well as an experimental setup including piezoelectric pressure sensors and qualitative observation of the free surface.The effect of two vertical baffles on the maximum pressure and the position of phase interface was determined.The comparison between the computational and experimental results reveals that the numerical model tends to under predict the experimental peak pressures but resolves the liquid surface in close agreement with the experiments. | Ronja Hoch Frank-Hendrik Wurm | 2021 | Journal of Hydrodynamics2021，33，4： | 2 |
| 10 | 德磐氢化丁腈橡胶的性能和应用(四)显示文摘介绍了德磐系列氢化丁腈橡胶的主要性能、配合原则,及其在密封件、垫片、油田、汽车胶带、胶管、胶辊等产品中的应用,指出德磐系列氢化丁腈橡胶不仅拥有丁腈橡胶的所有优势,还具有极佳的耐热、耐油、耐磨性,是许多工业用途的良好选择。 | 张文禹 韩涛 Aprtin Hoch Victor Nasreddine Andreas Bischoff Kevin Kulbaba | 2012 | 世界橡胶工业2012，39，4： | 2 |
| 11 | The Bacillus subtilis chromosome显示文摘 | Henner J Hoch J A | 1980 | Microbiol Rev1980，44，1： | 2 |
| 12 | 丁基橡胶三维溶度参数的测定及应用显示文摘采用溶胀法和计算机HSPiP软件模拟测定了丁基橡胶(IIR)的三维溶度参数,并研究了三维溶度参数在确定相对能量差(RED)与溶胀比(q)的关系及建立Teas二维溶度参数图中的应用。结果表明,IIR的三维溶度参数δd、δp、δh分别为17.1,1.2,0.7 MPa1/2,根据Hansen模型计算得出IIR的一维溶度参数为17.16 MPa1/2,与溶胀法测试结果基本一致;IIR的q值随着RED的增大而减小,并在RED为1时出现拐点,此时溶剂由良溶剂转变为不良溶剂;在Teas二维溶度参数图中,位于IIR溶解区域内的溶剂为良溶剂,溶解区域外的为不良溶剂。 | 李晓鹏 刘广永 徐正伟 赵树高 Martin Hoch | 2015 | 合成橡胶工业2015，38，3： | 2 |
| 13 | Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor positive breast carcinoma cell line显示文摘 | Kuang WW Thompson DA Hoch RV | | 0，，： | 2 |
| 14 | 无卤阻燃材料的吸油性对燃烧的影响显示文摘探讨了乙烯-醋酸乙烯酯共聚物(EVA或EVM)中,醋酸乙烯酯(VA)含量与材料耐油性能的关系,及其对材料阻燃性能的影响。研究发现,VA含量低,将导致吸油量高,体积膨胀高,阻燃性能损失大,意味着阻燃功能失效。 | 张文禹 Martin Hoch 张根平 Frank Taschner | 2013 | 世界橡胶工业2013，40，8： | 2 |
| 15 | Organotin compounds in the environment: An overview显示文摘 | Hoch M | 2001 | Appl Geochem2001，16，： | 1 |
| 16 | Auto-antibodies to the receptor tyrosine kinase MuSK in patients withmyasthenia gravis without acetylcholine receptor antibodies显示文摘 | Hoch W McConville J Helms S | 2001 | Nat Med2001，7，： | 1 |
| 17 | In vivo,in vitro, and moleculer aspects of interleukin - 8 and interleukin - 8 receptors显示文摘 | Hoch RC Schtaufstaetter IU Cochrane CG | 1996 | J Lab Clin Med1996，128，2： | 1 |
| 18 | Tumor necrosis factor-alpha in macrophages of heart,liver,kidney and in the pituitary gland显示文摘 | ARRAS MA HOCHE R BOHLE | 1996 | Cell Tissue Res1996，285，： | 1 |
| 19 | Multicentric giant cell tumor of bone Clinicopathologic analysis of thirty cases显示文摘 | Hoch B Inwards C Sundaram M | 2006 | 88 (9):1998-20082006，88，9： | 1 |
| 20 | Positioning of store brands显示文摘 | SAYMAN S HOCH S J RAJU J S | 2002 | Marketing Science2002，21，4： | 1 |
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