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| 1 | Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one- compound peptide libraries显示文摘one-bead-one-compound (OBOC ) 组合的肽图书馆是一个强大的工具识别 ligand 和受体相互作用。这里,我们使用了 OBOC 图书馆技术识别对主要贝壳变应原 tropomyosin 的免疫球蛋白 E (IgE ) epitopes 特定的 mimotopes。有 8-12 氨基酸残余的 OBOC 肽图书馆为 tropomyosin 的 IgE mimotopes 与贝壳过敏症从病人与浆液样品被屏蔽。25 mimotopes 从屏蔽被识别,他们到 tropomyosin 特定的 IgE 的有约束力的反应被肽 ELISA 证实。这些 mimotopes 能基于顺序相同被划分成七簇,并且由聚类的 mimotopes 的 EpiSearch 印射的 epitope 被执行描绘并且证实 mimotopes 的有效性。五从六预言的 epitopes 被发现与 tropomyosin 的以前识别的 epitopes 重叠。为了推进,证实 mimotopes 的模仿潜力, BALB/c 老鼠被使免疫, mimotopes 结合了到锁眼恋栈者 hemocyanin 和 assayed 让他们的能力导致 tropomyosin 特定的抗体。那收到的 mimotope 免疫被发现有 tropomyosin 特定的免疫球蛋白 G 的提高的水平的 BALB/c 老鼠,然而并非收到了无关的 mimotope 的老鼠。这研究用整个 sera 开创 OBOC 图书馆的成功的申请屏蔽并且识别多重虾变应原 mimotopes 并且验证他们在 vitro 使用的模仿潜力,在 vivo,并且在 silico 方法。 | Nicki YH Leung Christine YY Wai Marco HK Ho Ruiwu Liu Kit S Lam Jin Jun Wang Shang An Shu Ka Hou Chu Patrick SC Leung | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 2 | Surface crosslinking of high-density polythylene beads in a modified plasma reactor 显示文摘 | Jae WK Ho SC | 2002 | J Appl Polym Sci2002，83，： | 2 |
| 3 | Genetic and environmental risk factors for Parkinson's disease in a Chinese population显示文摘 | Woo J Ho SC | 1998 | J Neurosurg Psychiatry1998，65，： | 1 |
| 4 | Treatment of pyogenic liver abscess:prospective randomized comparison of catheter drainage and needle aspiration显示文摘 | Yu SC Ho SS Lau WY | 2004 | Hepatology2004，39，4： | 1 |
| 5 | Air pollution and hospital admissions for cardiovascular disease in Taipei, Taiwan 显示文摘 | Chang CC Tsai SS Ho SC | 2005 | Environ Res2005，98，11： | 1 |
| 6 | Mechanical properties of a new mica- based machinable glass ceramics for CAD/CAM restorations显示文摘 | Thompson JY Bayne SC Heymann HO | 1996 | J Prosthet Dent1996，76，6： | 1 |
| 7 | Identification of temisartan as a unique angiotensinⅡreceptor antagonist with selsctive PPARgamma-modulating activity J显示文摘 | Benson SC Pershadsingh HA Ho CI | 2004 | Hypertension2004，43，5： | 1 |
| 8 | Graves' ophthalmopathy in the absence of elevated free thyroxine and triiodothyronine levels : prev- alenc, natural history, and thyrotropin receptor antibody levels 显示文摘 | Khoo DH Eng PH Ho SC | 2000 | Thyroid2000，10，12： | 1 |
| 9 | Establishment of the mimetic aging effect in mice caused by D-galactose显示文摘 | Ho SC Liu JH Wu RY | 2003 | Biogerontology2003，4，1： | 1 |
| 10 | A study on pruritus after parathyroidectomy for secondary hyperparathyroidism显示文摘 | Chou FF Ho JC Huang SC | 2000 | J Am Coll Surg2000，190，： | 1 |
| 11 | Dietary patterns and breast Cancer risk among Chinese women 显示文摘 | Zhang Caixia Ho SC Fu Jianhua | 2011 | Cancer Causes Con- trol2011，22，1： | 1 |
| 12 | Expression of human estrogen receptor-alpha and-beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovariant epithelial cells 显示文摘 | Lau KM Mok SC Ho SM | 1999 | Proe Natl Acad Sci1999，96，8： | 1 |
| 13 | Identification of telmisartan as a unique angiotensin 1] receptor antagonist with se- lective PPARgamma-modulatingactivity显示文摘 | Benson SC Pershadsingh HA Ho CI | 2004 | Hypertension2004，43，5： | 1 |
| 14 | Evaluation of peroxynitrite-scav- enging capacities of several commonly used fresh spices显示文摘 | Ho SC Tang YL Lin SM | 2010 | Food Chem2010，119，3： | 1 |
| 15 | Dexamethasone reduces nausea and vomiting after laparoscopic cholecystectomy显示文摘 | Wang JJ Ho ST Lee SC | 1999 | Br J Anaesth1999，83，： | 1 |
| 16 | Differences in the levels of TSH- binding inhibitor immunoglobulins in goitrous and agoitrous autoimmune thyroiditis after twelve months of L-thyroxine therapy 显示文摘 | Khoo DH Eng PH Ho SC | 1999 | Clin Endocrinol(Oxf)1999，51，： | 1 |
| 17 | Tissue polypeptide specific anti- gen and squamous cell carcinoma antigen for early prediction of re- currence in lung squamous cell carcinoma 显示文摘 | Ho YJ Hsieh JF Tasi SC | 2000 | Lung2000，178，2： | 1 |
| 18 | Whole plant foods intake is associated with fewer menopausal symptoms in Chinese postmenopausal women with prehypertension or untreated hypertension显示文摘 | Liu ZM Ho SC Xie YJ | 2015 | Menopause2015，22，5： | 1 |
| 19 | Establishment of the mimetic aging effect in mice caused by D-galactose显示文摘 | Ho SC Liu JH Wu RY | 2003 | Biogerontology2003，4，1： | 1 |
| 20 | High habitual calcium intake attenuates bone loss in early postmenopausal Chinese women= An 18-month follow up study显示文摘 | Ho SC Chen YM Wooj LF | 2004 | J Clin Endocrinol Metab2004，5，： | 1 |
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