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	题名	作者	年代	出处	被引量
1	4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells.	Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon	2017	Cellular & Molecular Immunology2017，14，9：	6
2	The sorption of lead( Ⅱ ) ions on peat显示文摘	Ho Y S Mekay G	1999	Water IRes1999，33，2：	1
3	The US national cholesterol education programe adult treatment panel Ⅲ(NCEPATP Ⅲ) prevalence of the meta bolic syndrome in a Chinese population显示文摘	THOMAS G N HO S Y JANUS E D	2005	Diabetes Res Clin Pract2005，67，：	1
4	Kinetics of pollutant sorption by biosorbents : review 显示文摘	Ho Y S Ng J C McKay G	2000	Sep Purif Methods2000，29，2：	1
5	Batch lead( Ⅱ ) removal from aqueous solution by peat: Equilibrium and kinetics显示文摘	Ho Y S Mckay G	1999	Trans Ins Chem Eng1999，77，：	1
6	Pseudo-second order model for sorption processes显示文摘	Ho Y S MeKay G	1999	Process Biochemistry1999，34，：	1
7	Electroporation of cell membranes:a review显示文摘	Ho S Y Mittal G S	1996	Critical Reviews in Biotechnology1996，16，：	1
8	Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘	Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C	2009	Nature2009，458，7238：	1
9	A Multi Stage Batch Sorption Design with Experimental Data显示文摘	Ho Y S McKay G	1999	Adsorption Science and Technology1999，187，17：	1
10	A Particle Swarm Optimization Method with Enhanced Global Search Ability for Design Optimizations of Electromagnetic Devices显示文摘	Ho S L Yang S Y Ni G Z	2006	IEEE Trans on Magnetics2006，42，4：	1
11	The sorption of lead (Ⅱ) on peat显示文摘	Ho Y S 1999a	1999	Wat Res1999，33，：	1
12	The sorption of lead ions on peat 显示文摘	Ho Y S Mckay G	1999	Wat Res1999，33，2：	1
13	Pseudo-second order model for sorption processes显示文摘	Y S Ho G McKay	1999	Process Biochemistry1999，34，5：	1
14	Sorption of dye from aqueous solution by peat 显示文摘	Ho Y S McKay G	1998	Chemical Engineering Journal1998，70，：	1
15	Pseudo-second order model for sorption processes 显示文摘	Ho Y S McKay G	1999	Process Biochemisetry1999，34，5：	1
16	Pseudo-second order model for sorption processes 显示文摘	Ho Y S Mckay G	1999	Process Biochemistry1999，34，5：	1
17	Sorption of dye from aqueous solution by peat显示文摘	HO Y S MCKAY G	1998	Chemical Engineering Journal1998，70，：	1
18	Kinetic study of dye sorption by biosorbent waste product显示文摘	Ho Y S Mckay G A	1999	Resources Conservation and Recycling1999，25，：	1
19	Equilibrium isotherm studies for the sorption of divalent metal ions onto peat: copper, nickel and lead single component system显示文摘	Ho Y S Porter J F Mekay G	2002	Water Air Soil Poll2002，141，：	1
20	The sorption of lead ( Ⅱ ) ions on peat 显示文摘	Ho Y S McKay G	1999	Water Research1999，33，2：	1

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