|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003，9，10： | 5 |
| 3 | Identification of telmisartan as a unique angiotensin Ⅱ receptor antagonist with selective PPARγ-modulating activity 显示文摘 | BENSON S C PERSHADSINGH H A HO C I | 2004 | Hypertension2004，43，5： | 1 |
| 4 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 5 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 6 | Characteristics of carbonaceous aerosol in Pearl River Delta Region, China during 2001 winter period 显示文摘 | CAO J J LEE S C HO K F | 2003 | Atmos Environ2003，37，： | 1 |
| 7 | Short-term outcomes of 23-gauge pars plana vitrectomy显示文摘 | Gupta OP Ho A Kaiser PK Regillo C Chen S Dyer D | 2008 | Am J Ophthalmol2008，146，2： | 1 |
| 8 | Low-stress encapsulants by vinylsiloxane modification显示文摘 | Wang C S | 1994 | J of Appl Polym Sci1994，51，12： | 1 |
| 9 | Kinetics of pollutant sorption by biosorbents : review 显示文摘 | Ho Y S Ng J C McKay G | 2000 | Sep Purif Methods2000，29，2： | 1 |
| 10 | An integrated vendor-buyer inventory model with quality improvement and lead time reduction 显示文摘 | Ouyang LY Wub K S Ho C H | 2007 | International Journal of Production Economies2007，108，12： | 1 |
| 11 | Excentral cleavage of beta- carotene in vivo in a healthy man显示文摘 | HO C C de MOURA F F KIM S H | 2007 | Clin Nutr2007，85，3： | 1 |
| 12 | Cognitive Profilingand Preliminary Subtyping in Chinese Developmental Dys-lexia显示文摘 | HO C S CHAN D W LEE S H etal | 2004 | Cognition2004，91，1： | 1 |
| 13 | Characterization of selected volatile organic compounds, polycyclie aromatic hydrocarbons and earbonyl compounds at a roadside monitoring station 显示文摘 | HO K F LEE S C GLORIA M Y | 2002 | Atmos Environ2002，36，1： | 1 |
| 14 | Nuclear magnetic resonance studies of 5,7-dihydroxyflavonoids 显示文摘 | Shen C C Chang Y S Ho L K | 1993 | Phytochem1993，34，3： | 1 |
| 15 | Improvement of hybridyield by advanced backcross QTL analysis in elite maize显示文摘 | J C HO S R McCouch M E Smith | 2002 | Theor Appl Genet2002，105，： | 1 |
| 16 | The chemistry and biotransformation of tea constitu- ents 显示文摘 | Sang S M Joshua D L Ho C T | 2011 | Pharmacological Research2011，64，： | 1 |
| 17 | Positive sampling artifacts in particulate organic carbon measurements in roadside environment显示文摘 | CHENG Y LEE S C HO K F | 2010 | Environmental Monitoring and Assessment2010，168，1234： | 1 |
| 18 | A qualitative and quanti- tative review of antecedents of counterproductive behav- ior in organizations 显示文摘 | Lau V S Au W T & Ho J C | 2003 | Journal of Business and Psy- chology2003，18，1： | 1 |
| 19 | Hydroxylated polymethoxyflavones and methylated flavonoids in sweet orange(Citrus sinensis) peel显示文摘 | Li S Lo C Y Ho C T | 2006 | Journal of Agriculture Food Chemistry2006，54，： | 1 |
| 20 | 查看详情显示文摘 | Toulukian Y S Ho C Y | | 0，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员