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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection显示文摘Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research. | Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun Kavitha Ganta Antonios H Tzamaloukas | 2016 | World Journal of Transplantation2016，6，3： | 4 |
| 3 | Outcome analysis of intraventricular thrombolytic therapy for intraventricular haemorrhage 显示文摘 | LEE M W PANG K Y HO W W | 2003 | Hong Kong Med J2003，9，5： | 1 |
| 4 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 5 | Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population 显示文摘 | Horikoshi M Hara K ho C | 2007 | Diabetologia2007，50，12： | 1 |
| 6 | Subcutaneous lispro and intrave-nous regular insulin treatments are equally effective and safe for the treatment of mild and moderate diabetic ketoacidosis in adult patients显示文摘 | Ersoz HO Ukine K Kose M | 2006 | Int J Clin Pract2006，60，4： | 1 |
| 7 | Improved accuracy of computer --asssisted cervical pediele screw insertion显示文摘 | Kotani Y Abumi K ho M | 2003 | J Neurosurg2003，99，3： | 1 |
| 8 | Regulation of matrix metalloproteinases (MMP 2, 3, -9, and 13) by interleukin-1 and interleukin-6 in mouse calvaria: association of MMP induction with bone resorption显示文摘 | Kusano K Miyaura C Inada M Tamura T ho A Nagase H | 1998 | Endocrinology1998，139，： | 1 |
| 9 | Characterization of selected volatile organic compounds, polycyclie aromatic hydrocarbons and earbonyl compounds at a roadside monitoring station 显示文摘 | HO K F LEE S C GLORIA M Y | 2002 | Atmos Environ2002，36，1： | 1 |
| 10 | Immunosuppressive drugs prevent a rapid dephos?phorylation of transcription factor NF A Tl in stimulated immune cells显示文摘 | SHAW K T Y HO A M RAGHAVAN A | 1995 | Proc Natl Acad Sci USA1995，92，11： | 1 |
| 11 | Size, leverage, concentration, and R&D investment in generating growth opportunities 显示文摘 | Ho Y K Tjahjapraata M Yap C M | 2006 | Journal of Business2006，79，2： | 1 |
| 12 | Relationships between explanatory style, posttraumatic growth and posttraumatic stress disorder symptoms among Chinese breast cancer patients显示文摘 | Ho S M Y Chart M W Y Yau T K | 2011 | Psychology and Health2011，，3： | 1 |
| 13 | Crystal morphological investigation in thin films of poly(aryl ether ketone ketone) having a meta-linka_ge显示文摘 | Gardner K H Hsiao B S Ho R M | 1997 | Polymer1997，20，： | 1 |
| 14 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 15 | Real-time control of photoresist extinction coefficient uniformity in the microlithography process显示文摘 | Ho W K Kiew C M | 2007 | IEEE Transactions on Control Systems Technology2007，15，： | 1 |
| 16 | Non-linear pressure distribu-tion in microchannels显示文摘 | Ho C M | 1994 | Mechanical Engineering Congress and Exposition FED ASME1994，197，： | 1 |
| 17 | Nonbasal deformation modes of HCP metals and alloys: Role of dislocation source and mobility显示文摘 | Yoo M H Morris J R Ho K M | 2002 | Metall Mater Trans2002，33，： | 1 |
| 18 | Effects of the addition of titania on the thermal characterization of alumina - supported palladium显示文摘 | Wang C B Lin H K Ho C M | 2002 | J Mole Catal A2002，180，： | 1 |
| 19 | Wegener's granulornatosis upper respiralory tract and pulmonary radiographic manifestation in 30 cases with pathogenetic consideration 显示文摘 | Shin M S Young K R Ho K J | 1998 | Clinical Imaging1998，22，2： | 1 |
| 20 | Switching control of an R/C hovercraft: stabilization and smooth switching显示文摘 | TANAKA K IWASAKI M WANG HO | 2001 | IEEE Trans SMC-Part B: Cybernetics2001，31，6： | 1 |
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