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| 1 | 欧洲新生儿呼吸窘迫综合征防治指南-2010版显示文摘呼吸窘迫综合征(RDS)是由于肺表面活性物质(PS)缺乏及肺结构发育不成熟所致,多见于早产儿,自然病程为生后当时或很快发病,并在生后2d内进行性恶化,如不及时治疗,因进行性缺氧和呼吸衰竭而死亡,存活者,在生后2—4d病情开始改善。胎龄越小,RDS发生率越高,2006年EuroNeoStat的数据显示:胎龄23~25周的早产儿RDS发生率为91%, | Sweet DG Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 袁琳(翻译) 陈超(审校) | 2011 | 中华儿科杂志2011，49，1： | 137 |
| 2 | 欧洲早产儿呼吸窘迫综合征防治共识指南(2013版)显示文摘本次指南更新包括了自2010年以来Cochrane系统评价和医学文献中的最新证据,并采纳了一种新的证据评估分级系统(GRADE)。以往关于早期肺表面活性物质和持续气道正压通气治疗的推荐目前拥有了更坚定的循证依据。对产房复苏、稳定生命体征等内容进行了较大扩充。生命体征稳定后的氧疗目前仍存在一定的争议,但是在获得更多的证据之前,血氧饱和度的目标范围不应低于90%,支持治疗对于超早早产儿仍然极为重要。指南对其他注意事项进行了缩减。 | Sweet D Carnielli V Greisen G Hallman M Ozek E Plavka R Saugstad OD Simeoni U Speer CP Halliday HL 王敏婕 袁琳 陈超 | 2014 | 中华儿科杂志2014，52，10： | 34 |
| 3 | 肾周脂肪的产热活性促进肾透明细胞癌的进展并影响肿瘤治疗效果显示文摘肾细胞癌(RCC)是一种常见的致命恶性肿瘤,占所有成人癌症的2%以上,根据组织学和细胞遗传学特征,80%的肾细胞癌被细分为透明细胞肾细胞癌(ccRCC)。肾周脂肪组织(PAT)是一种位于肾筋膜和肾包膜之间的白色脂肪组织(WAT)。在肿瘤发生过程中,ccRCC细胞可穿透肾包膜并进入PAT,与肾癌预后不良相关。然而,ccRCC和PAT之间的相互作用还没有得到很好的研究。研究者通过对ccRCC细胞和PAT之间双向通信的深入探究发现,ccRCC细胞通过旁分泌模式分泌甲状旁腺激素相关蛋白(PTHrP)激活PKA途径驱动邻近的PAT褐变,使褐色变的肾周脂肪细胞代谢增强并释放大量的代谢产物,其中过量的乳酸被释放到肿瘤微环境中,从而促进ccRCC的生长、侵袭和转移,构成了一种新的促进ccRCC肿瘤生长的可能机制。该研究提示肾癌手术中切除邻近脂肪组织可能会阻止褐色脂肪细胞的代谢产物流动,从而改善手术后的预后。 | 杨濛(编译) 张宗勤(编译) Wei G Sun HL Dong K | 2021 | 中华医学杂志2021，101，46： | 6 |
| 4 | Mapping aboveground biomass and its prediction uncertainty using LiDAR and field data, accounting for tree-level allometric and LiDAR model errors显示文摘Background: The increasing availability of remotely sensed data has recently challenged the traditional way of performing forest inventories, and induced an interest in model-based inference. Like traditional design-based inference, model-based inference allows for regional estimates of totals and means, but in addition for wall-to-wall mapping of forest characteristics. Recently Light Detection and Ranging(LiDAR)-based maps of forest attributes have been developed in many countries and been well received by users due to their accurate spatial representation of forest resources. However, the correspondence between such mapping and model-based inference is seldom appreciated. In this study we applied hierarchical model-based inference to produce aboveground biomass maps as well as maps of the corresponding prediction uncertainties with the same spatial resolution. Further, an estimator of mean biomass at regional level, and its uncertainty, was developed to demonstrate how mapping and regional level assessment can be combined within the framework of model-based inference.Results: Through a new version of hierarchical model-based estimation, allowing models to be nonlinear, we accounted for uncertainties in both the individual tree-level biomass models and the models linking plot level biomass predictions with LiDAR metrics. In a 5005 km2 large study area in south-central Sweden the predicted aboveground biomass at the level of 18 m×18 m map units was found to range between 9 and 447 Mg·ha^-1. The corresponding root mean square errors ranged between 10 and 162 Mg·ha^-1. For the entire study region, the mean aboveground biomass was 55 Mg·ha^-1 and the corresponding relative root mean square error 8%. At this level 75%of the mean square error was due to the uncertainty associated with tree-level models.Conclusions: Through the proposed method it is possible to link mapping and estimation within the framework of model-based inference. Uncertainties in both tree-level biomass models and models linking plot level biomass with LiDAR data are accounted for, both for the uncertainty maps and the overall estimates. The development of hierarchical model-based inference to handle nonlinear models was an important prerequisite for the study. | Svetlana Saarela AndréWästlund Emma Holmström Alex Appiah Mensah Sören Holm Mats Nilsson Jonas Fridman Göran Ståhl | 2020 | Forest Ecosystems2020，7，3： | 3 |
| 5 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 6 | Sixteen-slice spiral CT versus MR imaging for the assessment of left ventricular function in acute myocardial infarction显示文摘 | Andreas H. Mahnken Ralf Koos Marcus Katoh Elmar Spuentrup Petra Busch Joachim E. Wildberger Harald P. Kühl Rolf W. Günther | 2005 | European Radiology2005，，4： | 2 |
| 7 | Comparison of estimators of variance for forest inventories with systematic sampling-results from artificial populations显示文摘Background:Large area forest inventories often use regular grids(with a single random start)of sample locations to ensure a uniform sampling intensity across the space of the surveyed populations.A design-unbiased estimator of variance does not exist for this design.Oftentimes,a quasi-default estimator applicable to simple random sampling(SRS)is used,even if it carries with it the likely risk of overestimating the variance by a practically important margin.To better exploit the precision of systematic sampling we assess the performance of five estimators of variance,including the quasi default.In this study,simulated systematic sampling was applied to artificial populations with contrasting covariance structures and with or without linear trends.We compared the results obtained with the SRS,Matern’s,successive difference replication,Ripley’s,and D’Orazio’s variance estimators.Results:The variances obtained with the four alternatives to the SRS estimator of variance were strongly correlated,and in all study settings consistently closer to the target design variance than the estimator for SRS.The latter always produced the greatest overestimation.In populations with a near zero spatial autocorrelation,all estimators,performed equally,and delivered estimates close to the actual design variance.Conclusion:Without a linear trend,the SDR and DOR estimators were best with variance estimates more narrowly distributed around the benchmark;yet in terms of the least average absolute deviation,Matern’s estimator held a narrow lead.With a strong or moderate linear trend,Matern’s estimator is choice.In large populations,and a low sampling intensity,the performance of the investigated estimators becomes more similar. | Steen Magnussen Ronald EMcRoberts Johannes Breidenbach Thomas Nord-Larsen Göran Ståhl Lutz Fehrmann Sebastian Schnell | 2020 | Forest Ecosystems2020，7，2： | 2 |
| 8 | Identification of an IL-27/ osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation 显示文摘 | Murugaiyan G Mittal A Weiner HL | 2010 | Proc Natl Acad Sci U S A2010，107，11： | 1 |
| 9 | The value of pos- tural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia显示文摘 | Frankle HL Hancock DO Hyslop G | 1969 | Paraplegia1969，7，3： | 1 |
| 10 | Aberrant HOXC expression accompanies the malignant phenotype in human prostate 显示文摘 | Miller G J Miller HL van Bokhoven A | 2003 | Cancer Res2003，63，18： | 1 |
| 11 | Community structure of denitrifiers, bacteria, and archaea along redox gradients in Pacific Northwest marine sediments by terminal restriction fragment length polymorphism analysis of amplified nitrite reductase (nitS) and 16S rRNA genes显示文摘 | Braker G Ayala-del-Rio HL Devol AH | 2001 | Applied and Environmental Microbiology2001，67，4： | 1 |
| 12 | Tumor size and pres?ence of calcifications on ultrasonography are pre- operative predictors of lymph node metastases in patients with papillary thyroid cancer显示文摘 | Gomez NR Kouniavsky G Tsai HL | 2011 | J Surg Oneal2011，104，6： | 1 |
| 13 | KLF6,a candidate tumor suppressor gene mutated in prostate cancer显示文摘 | Narla G Ileath KE Reeves HL | 2001 | Science2001，294，5551： | 1 |
| 14 | The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia显示文摘 | Frankel HL Hancock DO Hyslop G | 1969 | Spinal Cord1969，7，3： | 1 |
| 15 | Impaired renal function in patients with ischemic and nonischemic chronic heart failure:Association with neurohormonal activation and survival显示文摘 | Smilde TD Hillege HL Navis G | 2004 | Am Heart J2004，148，1： | 1 |
| 16 | The value of pos-tural reduction in the initial management of closed injuriesof the spine with paraplegia and tetraplegia 显示文摘 | Frankel HL Hancock DO Hyslop G | 1969 | Paraplegia1969，7，3： | 1 |
| 17 | Tumors of bones and joints 显示文摘 | Jaffe HL Selin G | 1951 | Bull N Y Acad Med1951，3，： | 1 |
| 18 | Sensitivity to change of the cutaneous electrical perceptual threshold test in longitudinal monitoring of spinal cord injury显示文摘 | Savic G Frankel HL Jamous MA | 2011 | Spinal Cord2011，49，43： | 1 |
| 19 | The value of postural reduction in the initial management of closed in-juries of the spine with paraplegia and tetraplegia 显示文摘 | Frankel HL Hancock DO Hyslop G | 1969 | Paraplegia1969，7，3： | 1 |
| 20 | 肾阻力指数和慢性肾脏病患者死亡率的关系显示文摘通过多普勒超声测量的肾阻力指数(renalresis—tiveindex,RRI)与高血压、糖尿病、老年患者心血管事件及死亡率相关。研究人员对高RRI(≥0.70)的影响因素,及其与无。肾动脉狭窄的肾脏病患者死亡率间的相关性进行评估。 | Toledo C Thomas G Schold JD Arrigain S Gornik HL Nally JV Navaneethan SD 刘莉 叶鹏 | 2015 | 中华高血压杂志2015，23，6： | 1 |
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