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| 1 | Association between high cystatin C levels and carotid atherosclerosis显示文摘AIM To investigate the association between carotid atherosclerosis and cystatin C(CysC) and to determine the optimal CysC cut-off value.METHODS One hundred twenty-eight subjects were included in this study. Atherosclerosis was defined as a maximum carotid plaque thickness(MCPT) of greater than 2 mm. A receiver operating characteristic curve analysis was used to determine the diagnostic value of serum CysC for atherosclerosis. The subjects were divided into two groups according to the CysC cut-off value. We screenedfor diabetes, hypertension, dyslipidemia, smoking status, alcohol consumption, and exercise behavior. The association between atherosclerosis and CysC levels was assessed using multivariate analysis.RESULTS The subjects were then divided into two groups according to the CysC cut-off value(0.73 mg/L). The median age of the high CysC group was 72 years(85% males), whereas that of the low CysC group was 61 years(63% males). The CysC levels were significantly correlated with Cr and estimated glomerular filtration rate(eGFR) values. Bodymass index, visceral fat area, hypertension, diabetes mellitus, and MCPT were significantly higher in the high CysC group than in the low CysC group. Furthermore, the eG FR was significantly lower in the high CysC group. Regarding lifestyle habits, only the exercise level was lower in the high CysC group than in the low CysC group. Multivariate analysis, adjusted for age and sex, revealed that high CysC levels were significantly associated with an MCPT of ≥ 2 mm(odds ratio: 2.92; 95%CI: 1.13-7.99).CONCLUSION Higher CysC levels were associated with an MCPT of ≥ 2 mm. The CysC cut-off value of 0.73 mg/L appears to aid in the diagnosis of atherosclerosis. | Toshiyuki Kobayashi Hirohide Yokokawa Kazutoshi Fujibayashi Tomomi Haniu Teruhiko Hisaoka Hiroshi Fukuda Toshio Naito | 2017 | World Journal of Cardiology2017，9，2： | 26 |
| 2 | Coincidence between malignant perivascular epithelioid cell tumor arising in the gastric serosa and lung adenocarcinoma显示文摘A 4-mo history of both epigastralgia and back pain was presented in a 39-year-old male. Computed tomography showed right lung nodule and abdominal mass attached to the gastric wall, measuring approximately 30 mm and 70 mm in diameter. Since biopsy samples from the lung and abdomen revealed poorly differentiated adenocarcinoma and malignant tumor, clinicians first interpreted the abdominal mass as metastatic carcinoma, and a right lower lobectomy with following resection of the mass was performed. Gross examination of both lesions displayed gray-whitish to yellow-whitish cut surfaces with hemorrhagic and necrotic foci, and the mass attached to the serosa of the lesser curvature on the gastric body. On microscopic examination, the lung tumor was composed of a proliferation of highly atypical epithelial cells having abundant eosinophilic cytoplasm, predominantly arranged in an acinar or solid growth pattern with vessel permeation, while the abdominal tumor consisted of sheets or nests with markedly atypical epithelioid cells having pleomorphic nuclei and abundant eosinophilic to clear cytoplasm focally in a radial perivascular or infiltrative growth pattern. Immunohistochemically, the latter cells were positive for HMB45 or α-smooth muscle actin, but the former ones not. Therefore, we finally made a diagnosis of malignant perivascular epithelioid cell tumor(PEComa) arising in the gastric serosa, combined with primary lung adenocarcinoma. Furthermore, small papillary car-cinoma of the thyroid gland was identified. The current case describes the coincidence of malignant PEComa with other carcinomas, posing a challenge in distinction from metastatic tumor disease. | Sohsuke Yamada Atsunori Nabeshima Hirotsugu Noguchi Aya Nawata Hisae Nishii Xin Guo Ke-Yong Wang Masanori Hisaoka Toshiyuki Nakayama | 2015 | World Journal of Gastroenterology2015，21，4： | 2 |
| 3 | Retarded liver growth in intedeukin-6-deficient and tumor necrosis factor receptor-1-deficient mice显示文摘 | WALLENIUS V WALLENIUS K HISAOKA M | 2001 | Endocrinology2001，142，： | 1 |
| 4 | Spinal epithel lOld hemangioendothelioma with epithelioid angiosarcomatous areas 显示文摘 | Hisaoka M Okamoto S Aoki T | 2005 | Skeletal Radiol2005，34，11： | 1 |
| 5 | Extraskeletal myxoid chon-drosarcoma:a clinicopathologic,immunohistochemical,and mo-lecular analysis of18cases显示文摘 | Okamoto S Hisaoka M Ishida T | 2001 | Hum Pathol2001，32，10： | 1 |
| 6 | Microtubule-associated protein-2 and class Ⅲ beta-tubulin are expressed in extraskeletal myxoid chondmsareoma显示文摘 | Hisaoka M Okamoto S Koyama S | 2003 | Mod Pathol2003，16，5： | 1 |
| 7 | Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders显示文摘 | Takebayashi M Hisaoka K Nishida A | 2006 | Int J Neuropsychopharmacol2006，9，： | 1 |
| 8 | Clinical electrophysiological characteristic of atrial standstill 显示文摘 | Nakazato Y Nakata Y Hisaoka T | 1995 | PACE1995，18，6： | 1 |
| 9 | Extraskeleteral myxiod chondrosarcoma:a clinicopathologic,immunohistochemical,and molecular analysis of 18 cases显示文摘 | Okamoto S Hisaoka M Ishida T | 2001 | Hum Pathol2001，32，10： | 1 |
| 10 | HMGIC altera- tions in smooth muscle tumors of soft tissues and other sits 显示文摘 | Hisaoka M Sheng WQ Tanaka A | 2002 | Cancer Genet Gytogenet2002，138，1： | 1 |
| 11 | Morphological changes of hepaticmicrocirculation in experimental rat cirrhosis:A scanning electron microxcopic study显示文摘 | Haratake J Hisaoka M Yamamoto o | 1991 | Hepatology1991，13，： | 1 |
| 12 | Extrapleural solitary fibrous tumor: clinicopathologic study of 17 cases and molecular analysis of the p53 pathway显示文摘 | Morimitsu Y Nakajima M Hisaoka M | 2000 | APMIS2000，108，61： | 1 |
| 13 | infantile fibrosarco- ma a clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues显示文摘 | Sheng WQ Hisaoka M Okamoto S | 2001 | Am J Clin Pathol2001，115，3： | 1 |
| 14 | Detection of SYTSSX fusion transcripts in synovial sarcoma by reverse transcriptionpolymerase chain reaction using archival paraffin-embedded tissues 显示文摘 | Tsuji S Hisaoka M Morimitsu Y | 1998 | Am J Pathol1998，153，： | 1 |
| 15 | Clear cell sarcoma of softtissue : a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases 显示文摘 | Hisaoka M Ishida T Kuo TT | 2008 | Am J Surg Pathol2008，32，3： | 1 |
| 16 | Pulmonary hypoplasia on preterm infant associated with diffuse chorioamniotic hemosiderosis caused by intrauterine hemorrhage due to massive subchorial hematoma:Report of a neonatal autopsy case显示文摘 | Yamada S Marutani T Hisaoka M | 2012 | Pathology International2012，62，8： | 1 |
| 17 | Clear cell sarcoma of soft tis-sue:a clinicopathologic,immunohistochemical,and molecular anal-ysis of33cases显示文摘 | Hisaoka M Ishida T Kuo TT | 2008 | Am J Surg Pathol2008，32，3： | 1 |
| 18 | Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcriptionpolymerase chain reaction using archival paraffin-embedded tissues显示文摘 | Tsuji S Hisaoka M Morimitsu Y et a1 | 1998 | AmJ Pathol1998，153，6： | 1 |
| 19 | The Tokyo subway sarin attack-lessons learned显示文摘 | Okumura T Hisaoka T Yamada A | 2005 | Toxicol Appl Pharmacol2005，207，2： | 1 |
| 20 | Primary synovial sarcoma of the lung: report of two eases confirmed by molecular detection of SYT-SSX fusion gene transcripts 显示文摘 | Hisaoka M Hashimoto H Iwamasa T | 1999 | Histopathology1999，34，3： | 1 |
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