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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | 臂间血压差与脑卒中的关系显示文摘为了检测同时测量的双臂血压差值是否可识别踝臂血压指数〈0.90的受试者,及是否能预测未来心血管事件,Hirofumi等收集来自10个队列的日本受试者13 317人的数据(基于一般人群的队列,既往有心血管事件病史的队列及有心血管病危险因素的队列)进行荟萃分析。 | 刘青 叶鹏 Hirofumi T Toshiaki O Toshiharu N Chisa M Kazuomi K Satoshi H Yoshikuni K Toyoshi I Yasutaka M Katsuhiko K Yasuharu T Motoyuki N Takayoshi O Hirotaka W Masanori M Mitsuru O Norihisa I Michinari N Tetsuo S Charalambos V Akira Y | 2018 | 中华高血压杂志2018，26，6： | 3 |
| 3 | Effect of blood pressure and diabetes on stroke inprogression显示文摘 | Hirofumi N Otto R | 1994 | Lancet1994，344，： | 1 |
| 4 | Methylation status of breast cancer resistance protein detected by methylation-specific polymerase chain reaction analysis is correlated inversely with its expression in drug resistant lung cancer cells显示文摘 | Hirofumi N Yoichi N Hiroshi S | 2008 | Cancer2008，112，5： | 1 |
| 5 | Improved preserva- tion of function during acoustic neuroma surgery 显示文摘 | Hirofumi N Hidemi M Minoru T | 2015 | Jour- nal of Neurosurgery2015，122，1： | 1 |
| 6 | Radiofrequency ablation for hepatocellular carcinoma induces glypican-3 peptide-specific cytotoxic T lymphocytes显示文摘 | Daisuke N Yutaka M Hirofumi S | 2012 | Inter Journal Oncology2012，40，： | 1 |
| 7 | A Flexible Intravenous (IV) Catheter Should Be Used for a Chemotherapeutic IV Device to Prevent Drug Extravasation显示文摘 | Hirofumi Mukai N Katsumata K Ishii | 2000 | American Society of Clinical Oncology2000，8，1： | 1 |
| 8 | Effects of jump and balance training on knee kinematics and electromyo- graphy of female basketball athletes during a single limb drop landing: pre-post intervention study显示文摘 | YASUHARU N HIROFUMI I MASAMI A | 2011 | Sports Med Arthros- copy Rehabilitation Therapy Technology2011，3，14： | 1 |
| 9 | Design and performance of a bidirectional isolated dc-dc converter for a battery energy storage system 显示文摘 | Tan N M L Abe T Hirofumi A | 2012 | IEEE Transactions on Power Electronics2012，27，3： | 1 |
| 10 | Lifestyle obesity and insulin resist- ance显示文摘 | Hirofumi S Masako S Atsuko N | 2001 | Diabetes Care2001，24，： | 1 |
| 11 | Induction of mammalian topoisomerase II dependent DNA cleavage by nonintercalative flavonoids,genistein and orobol显示文摘 | Yoshinori Y Sho-Zou K Hirofumi N | 1990 | Biochemical Pharmacology1990，39，4： | 1 |
| 12 | Climate-driven increases in global terrestrial net primary production from 1982 to 1999显示文摘 | Ramakrishna R N Charles D K Hirofumi H | 2003 | Science2003，300，： | 1 |
| 13 | Peripheral blood extrathymic CD4^+ CD8^+ T ceils with high cytotoxic activity are form the same lineage as CD4^+ CD8^- T ceils in cynomolgus monkeys显示文摘 | Ki-Hoan N Hirofumi A Keiji T | 2000 | International Immunol2000，12，7： | 1 |
| 14 | Instantaneous reactive power compensators comprising switching devices without energy storage components 显示文摘 | HIROFUMI A YOSHIHIRA K AKIRA N | 1984 | IEEE Trans on Industry Applications1984，20，3： | 1 |
| 15 | Effect of bloodpressure and diabetes on storke in progress显示文摘 | Henrik SJ Hirofumi N Otto R | 1994 | Lancet1994，344，： | 1 |
| 16 | Novel therapeutic option for re- fractory heart failure in elderly patients with chronic kidney disease by incremental peritoneal dialysis显示文摘 | Masaru N Hirofumi N Masaaki N | 2010 | Journal of Cardiology2010，55，1： | 1 |
| 17 | A new neutral-point-clamped PWM inverter显示文摘 | Akira N Isao T Hirofumi A | 1981 | IEEE Transactions on Industrial Application1981，17，5： | 1 |
| 18 | Effect of blood pressure and diabetes on stroke in progression显示文摘 | Hirofumi N Otto R | 1994 | Lancet1994，344，8916： | 1 |
| 19 | A flexible intravenous(Iv)catheter should be used for a chemotherapeutic TV device to prevent drug extravasation显示文摘 | Hirofumi Mukai N Katsumata K Ishii | 2000 | American Society of Clinical Oncology2000，8，1： | 1 |
| 20 | L-serbose induces cellulase gene transcription in the cellulolytic fungus Trichoderma reesei显示文摘 | Masohiro N Masahiro G Hirofumi O | 2001 | Curt Genet2001，，38： | 1 |
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