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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | Executive dysfunction in cocaine addiction: Evidence for discordant frontal, cingulate, and cerebellar activity 显示文摘 | Hester R Garavan H | 2004 | J Neurosci2004，24，11： | 1 |
| 3 | A pilot randomised con- trolled trial of modafinil during acute methamphetamine withdraw- al: Feasibility, tolerability and clinical outcomes显示文摘 | Lee N Pennay A Hester R | 2012 | Drug Alco- hol Rev2012，，： | 1 |
| 4 | Gas hydrate measurements at Hydrate Ridge using Raman spectroscopy显示文摘 | HESTER K C DUNK R M WHITE S N | 2007 | Geochimica et Cosmochimica Acta2007，71，： | 1 |
| 5 | The determination of hemodialysis blood recirculation using blood urea nitrogen measurements 显示文摘 | Hester R L Curry E Bower J | 1992 | Am J Kidney D s1992，20，： | 1 |
| 6 | Inter-rater reliability of the Inter- national Cooperative Ataxia Rating Scale (ICARS) 显示文摘 | Storey E Tuck K Hester R | 2004 | Mov Dis- ord2004，19，： | 1 |
| 7 | Using Technical Innovations in Clinical Prac- tice : The Drinker's Check - Up Software Program 显示文摘 | Squires DD Hester R | 2004 | Journal of Clinical Psychology2004，60，2： | 1 |
| 8 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococeus species 显示文摘 | VILGALYS R HESTER M | 1990 | Journal of Bacteriolgy1990，172，： | 1 |
| 9 | Mode losses in hollow-waveguide显示文摘 | Hester A N Abrams R L | 1972 | Appl Phys Lett1972，21，： | 1 |
| 10 | Neural correlates of attentional bias in addiction显示文摘 | Hester R Luijten M | 2014 | CNS Spectr2014，19，： | 1 |
| 11 | Acid/sugar separation using ion exclusion resin:A process analysis and design显示文摘 | Nanguneri S R Hester R D | 1990 | Separation Science and Technology1990，25，1315： | 1 |
| 12 | Cryptococcal immune reconstitu- tion inflammatory syndrome: report of four cases in three patients and review of the literature显示文摘 | Sklest D J Hester L J Hardy R D | 2005 | J Infect2005，51，5： | 1 |
| 13 | Discovery and initial development of a novel class of antibacterials:inhibitors of Staphylococcus aureus transcription/translation显示文摘 | Larsen S D Hester M R Craig Ruble J | | 0，，24： | 1 |
| 14 | Continuous ion-exclusion chromatography system for acid/sugar separation显示文摘 | Springfield R M Hester R D | 1999 | Separation Science and Technology1999，34，67： | 1 |
| 15 | Ex vivo-expanded human regulatory T cells prevent the rejection of skin allografts in a humanized mouse model显示文摘 | lssa F Hester J Goto R | 2010 | Transplantation2010，90，12： | 1 |
| 16 | Bone densitometry as indicator of percentage tibia ash in broiler chicks fed varying dietary calcium and phosphorus levels 显示文摘 | ONYANGO E M HESTER P Y STROSHINE R | 2003 | Poultry Science2003，82，： | 1 |
| 17 | Clinical,demographic,and situational factors linked to distress associated with benign breast biopsy显示文摘 | Steffens R F Wright H R Hester M Y | 2011 | J Psychosoc Oncol2011，29，1： | 1 |
| 18 | Moving beyond the banks: hyporheic restoration is fundamental to restoring ecologicalservices and functions显示文摘 | Hester E R Gooseff M N | 2010 | Environmental Science and Technology2010，44，5： | 1 |
| 19 | In vitro biological evaluation of high molecular weight hyperbranched polyglycerols显示文摘 | Kainthan R K Hester S R Levin E | 2007 | Biomaterials2007，28，31： | 1 |
| 20 | A consistent attentional bias for drug - related material in active cocaine users across word and picture versions of the emotional Stroop task显示文摘 | Hester R Dixon V Garavan H | 2006 | Drug Alcohol Depend2006，81，3： | 1 |
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