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| 1 | 含层理构造的非均质片麻岩巴西劈裂试验及离散单元法数值模拟研究显示文摘为了研究岩石各向异性及非均质性对其破坏形式的影响,对含层理构造的非均质片麻岩进行了多组加载角度的巴西劈裂试验,获得不同层理方向片麻岩试件'抗拉强度'。其计算'抗拉强度'随着层理方向与加载方向夹角减小而迅速减小,当层理方向平行于加载方向时,计算'抗拉强度'可认为是片麻岩软弱层理面间的抗拉强度;当层理方向垂直于加载方向时,计算'抗拉强度'可认为是片麻岩岩石矿物基质的等效抗拉强度;当层理方向与加载方向夹角小于90°时,则属于拉–剪复合破坏形式,是片麻岩各向异性和非均质性共同作用的结果,此时对计算'抗拉强度'的应用需要特别谨慎。用UDEC程序建立离散单元数值模型,利用随机分布的条状块体集合,通过设置层理界面和矿物颗粒之间的接触参数,模拟层理构造对片麻岩破坏的影响。数值模拟与试验结果吻合较好,解释了劈裂破坏形式产生的机制,揭示岩石在荷载状态下的破裂过程是裂纹从萌生初期的无序分布,到受微观构造影响而有序集中的自组织过程。 | 谭鑫 HEINZ Konietzky | 2014 | 岩石力学与工程学报2014，33，5： | 31 |
| 2 | Predictive value of Ki67 and p53 in locally advanced rectal cancer:Correlation with thymidylate synthase and histopathological tumor regression after neoadjuvant 5-FU-based chemoradiotherapy显示文摘AIM: To investigate the predictive value of Ki67 and p53 and their correlation with thymidylate synthase (TS) gene expression in a rectal cancer patient cohort treated according to a standardized recommended neoadjuvant treatment regimen.METHODS: Formalin fixed, paraffin embedded pre-therapeutical tumor biopsies (n = 22) and post-therapeutical resection specimens (n = 40) from patients with rectal adenocarcinoma (clinical UICC stage Ⅱ/Ⅲ) receiving standardized neoadjuvant 5-fluorouracil (5-FU) based chemoradiotherapy were studied for Ki67 and p53 expression by immunohistochemistry and correlated with TS mRNA expression by quantitative TaqMan real-time PCR after laser microdissection. The results were compared with histopathological tumor regression according to a standardized semiquantitative score grading system.RESULTS: Responders (patients with high tumor regression) showed a significantly lower Ki67 expression than non-responders in the pre-therapeutical tumor biopsies (81.2% vs 16.7%; P < 0.05) as well as in the post-therapeutical resection specimens (75.8% vs 14.3%; P < 0.01). High TS mRNA expression was significantly correlated with a high Ki67 index and low TS mRNA expression was significantly correlated with a low Ki67 index in the pre-therapeutical tumor biopsies (corr. coef. = 0.46; P < 0.01) as well as in the post-therapeutical resection specimens (corr. coef. = 0.40; P < 0.05). No significant association was found between p53 and TS mRNA expression or tumor regression.CONCLUSION: Ki67 has, like TS, predictive value in rectal cancer patients after neoadjuvant 5-FU based chemoradiotherapy. The close correlation between Ki67 and TS indicates that TS is involved in active cell cycle processes. | Christiane Jakob Torsten Liersch Wolfdietrich Meyer Heinz Becker Gustavo B Baretton Daniela E Aust | 2008 | World Journal of Gastroenterology2008，14，7： | 29 |
| 3 | Calpain system and its involvement in myocardial ischemia and reperfusion injury显示文摘Calpains are ubiquitous non-lysosomal Ca2+-dependent cysteine proteases also present in myocardial cytosol and mitochondria.Numerous experimental studies reveal an essential role of the calpain system in myocardial injury during ischemia,reperfusion and postischemic structural remodelling.The increasing Ca2+-content and Ca2+-overload in myocardial cytosol and mitochondria during ischemia and reperfusion causes an activation of calpains.Upon activation they are able to injure the contractile apparatus and impair the energy production by cleaving structural and functional proteins of myocytes and mitochondria.Besides their causal involvement in acute myocardial dysfunction they are also involved in structural remodelling after myocardial infarction by the generation and release of proapoptotic factors from mitochondria.Calpain inhibition can prevent or attenuate myocardial injury during ischemia,reperfusion,and in later stages of myocardial infarction. | Christiane Neuhof Heinz Neuhof | 2014 | World Journal of Cardiology2014，6，7： | 23 |
| 4 | Diet therapy for inflammatory bowel diseases: The established and the new显示文摘Although patients with inflammatory bowel diseases(IBD) have a strong interest in dietary modifications as part of their therapeutic management, dietary advice plays only a minor part in published guidelines. The scientific literature shows that dietary factors might influence the risk of developing IBD, that dysbiosis induced by nutrition contributes to the pathogenesis of IBD, and that diet may serve as a symptomatic treatment for irritable bowel syndrome-like symptoms in IBD. The role of nutrition in IBD is underscored by the effect of various dietary therapies. In paediatric patients with Crohn's disease(CD) enteral nutrition(EN) reaches remission rates similar to steroids. In adult patients, however, EN is inferior to corticosteroids. EN is not effective in ulcerative colitis(UC). Total parenteral nutrition in IBD is not superior to steroids or EN. The use of specific probiotics in patients with IBD can be recommended only in special clinical situations. There is no evidence for efficacy of probiotics in CD. By contrast, studies in UC have shown a beneficial effect in selected patients. For patients with pouchitis, antibiotic treatment followed by probiotics, like VSL#3 or Lactobacillus GG, is effective. When probiotics are used, the risk of bacterial translocation and subsequent bacteremia has to be considered. More understanding of the normal intestinal microflora, and better characterization of probiotic strains at the phenotypic and genomic levels is needed as well as clarification of the mechanisms of action in different clinical settings. A FODMAP reduced diet may improve symptoms in IBD. | Franziska Durchschein Wolfgang Petritsch Heinz F Hammer | 2016 | World Journal of Gastroenterology2016，22，7： | 22 |
| 5 | 大气中16种多环芳烃化合物高效液相色谱法测定显示文摘目的建立一种用高效液相色谱法同时测定大气中16种多环芳烃化合物的方法。方法用粉尘采样器、聚四氟乙烯滤膜和高分子多孔微球管采集大气中多环芳烃化合物,滤膜用乙腈:甲醇(60∶40)为溶剂,超声波提取多环芳烃化合物;吸收管用乙腈:甲醇(60∶40)、二氯甲烷洗脱,洗脱液经真空干燥后用乙腈:甲醇(60∶40)定容。用乙腈和水作为流动相,进行反相高效液相色谱梯度淋洗分离,程序波长荧光检测器检测。结果16种多环芳烃化合物测定的相对标准偏差为1.1%~5.6%,方法检测限为2.14×10^(-4)~4.3233×10^(-2)μg/ml,回收率为83.6%~98%,均符合方法学要求。结论该方法具有快速简便、准确灵敏、重现性好等优点,能全面真实地反映大气中多环芳烃化合物浓度。 | 郑红燕 汪利民 谭皓 Heinz Assenmacher-Maiworm 邬堂春 陈卫红 | 2006 | 中华劳动卫生职业病杂志2006，24，9： | 17 |
| 6 | 知识分子危机与批判精神的复苏(一)显示文摘 | 索飒 海因兹.迪特里齐(Heinz Dieterich) | 2002 | 读书2002，，5： | 15 |
| 7 | 呈现科研数据知识库:re3data.org注册机制显示文摘科研人员在钻研科研问题与分享科研数据的过程中,需要某种基础设施来确保数据最大程度的获取性、稳定性和可用性。这类基础设施可以统称为科研数据知识库(Research Data Repository,RDR)。自2012年启动的re3data.org项目,主要从事科研数据知识库的登记注册,以及为科研人员、科研资助组织、图书馆和出版商等提供有关异构科研数据知识库的全景概述。截至2013年7月,已有400个科研数据知识库向re3data.org登记,其中288个采用re3data.org的信息图标,以协助科研人员遴选合适的知识库,并且存储与重用他们的数据。这篇论文描绘异构RDR的全景,表述机构的、学科的、跨学科的以及项目专业的RDR类型。深入描述re3data.org的特性,以及这套注册系统如何协助科研人员分辨适合存储和搜索科研数据的知识库。 | Heinz Pampel Paul Vierkant Frank Scholze Roland Bertelmann Maxi Kindling Jens Klump Hans-Jürgen Goebelbecker Jens Gundlach Peter Schirmbacher Uwe Dierolf 顾立平 | 2014 | 现代图书情报技术2014，，3： | 15 |
| 8 | 甘肃玉门火烧沟遗址出土红-黄色混合颜料的再分析显示文摘古代颜料的科学分析一直是考古学研究和艺术史研究的重要内容,分析和确定颜料的矿物成分,对于中国古代科技史研究具有很重要的意义。本工作利用扫描电子显微镜和激光拉曼显微镜对玉门火烧沟遗址出土的红黄色颜料进行了分析,确定了红黄色混合颜料是雄黄、拟雄黄、三氧化二砷、硫磺与石膏的混合物。 | 马清林 Heinz Berke | 2006 | 文物保护与考古科学2006，18，1： | 11 |
| 9 | 山东青州西汉彩绘陶俑紫色颜料研究显示文摘 | 张治国 马清林 Heinz Berke | 2010 | 文物2010，，9： | 9 |
| 10 | Premotor Diagnosis of Parkinson's Disease显示文摘Typical Parkinsonian symptoms consist of bradykinesia plus rigidity and/or resting tremor. Some time later postural instability occurs. Pre-motor symptoms such as hyposmia, constipation, REM sleep behavior disorder and depression may antecede these motor symptoms for years. It would be ideal, if we had a biomarker which would allow to predict who with one or two of these pre-motor symptoms will develop the movement disorder Parkinson's disease(PD). Thus, it is interesting to learn that biopsies of the submandibular gland or colon biopsies may be a means to predict PD, if there is a high amout of abnormally folded alpha-synuclein and phosphorylated alpha-synuclein. This would be of relevance if we would have available means to stop the propagation of abnormal alpha-synuclein which is otherwise one of the reasons of this spreading disease PD. | Heinz Reichmann | 2017 | Neuroscience Bulletin2017，33，5： | 9 |
| 11 | Vessel density in OCT angiography permits differentiation between normal and glaucomatous optic nerve heads显示文摘AIM:To evaluate whether optical coherence tomography angiography(OCTA) can detect altered vessel density(VD) at the optic nerve head(ONH) in glaucoma patients.Special attention is paid to the accuracy of the OCTA technique for distinguishing healthy from glaucomatous eyes.METHODS:A total of 171 eyes were examined by the OCTA system Angio Vue^(TM)(Optovue):97 eyes diagnosed with glaucoma and 74 healthy control eyes.The papillary and peripapillary VD was measured.Furthermore,the VD was correlated with different structural and functional measurements.In order to test the accuracy of differentiation between eyes with and without glaucoma,we calculated the receiver operating characteristic curve(ROC) and the area under the curve(AUC).RESULTS:The papillary and peripapillary VD in glaucomatous eyes was significantly lower than in healthy eyes(P<0.05).The VD of the nasal peripapillary sector was significantly lower than in the other sectors.The further the disease had progressed [measured by determining the thickness of the ganglion cell complex(GCC) and the retinal nerve fiber layer(RNFL)] the greater the VD reduction.The AUC discriminated well between glaucomatous and normal eyes(consensus classifier 94.2%).CONCLUSION:OCTA allows non-invasive quantification of the peripapillary and papillary VD,which is significantly reduced in glaucomatous eyes and accurately distinguishes between healthy and diseased eyes.OCTA expands the spectrum of procedures for detecting and monitoring glaucoma. | Claudia Lommatzsch Kai Rothaus Joerg Michael Koch Carsten Heinz Swaantje Grisanti | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 9 |
| 12 | 室温累积叠轧Mg/Al多层复合板材的界面表征显示文摘通过室温累积叠轧技术制备了Mg/Al多层复合板材,借助SEM、EDS、TEM和同步辐射CT形貌观察等先进表征手段对累积叠轧Mg/Al金属复合板材界面结合进行表征,揭示累积叠轧Mg/Al金属复合板材界面宏观结合状态以及微观界面结构。结果表明,Mg/Al复合板材界面总体上结合良好,没有明显孔洞和开裂,但板材内部仍然存在一些孔洞和局部微小裂纹。3次循环后Mg/Al界面处形成了厚度为150 nm的Mg_(17)Al_(12)层。Mg和Mg_(17)Al_(12)之间存在一种确定的晶体学位相关系[111]Mg_(17)Al_(12)//[1210]Mg、(110)Mg_(17)Al_(12)//(1011)Mg,而Mg_(17)Al_(12)和Al之间是否有位相关系并不明显。 | 常海 郑明毅 Heinz Guenter Brokmeier 甘为民 | 2017 | 金属学报2017，53，2： | 8 |
| 13 | HIPIMS技术制备CrN及CrAlN涂层的性能显示文摘用高能脉冲靶和双极脉冲靶共溅射的方式,采用高功率脉冲磁控溅射技术(HIPIMS)在高速钢基片(W18Cr4V)上制备了CrN涂层和CrAlN涂层((H+B)CrN、(H+B)CrAlN);同时采用第四代电弧离子镀技术(ARC evaporators)在高速钢基片上制备了CrN涂层和CrAlN涂层(ARC CrN、ARC CrAlN)。采用划痕试验、X射线衍射、扫描电镜和电化学腐蚀测试等研究了涂层的形貌和性能。结果表明:共溅射制备的涂层膜基结合力更强,临界载荷最高可达到72.2 N,表面晶粒更细小,缺陷少,横截面组织致密;同时该方法制备的CrAlN((H+B)CrAlN)涂层的高温抗氧化性能最佳;共溅射制备的涂层的耐腐蚀性能比电弧离子镀制备的涂层更好。 | 朱宇杰 马景灵 王广欣 秦聪慧 Heinz Rolf Stock | 2019 | 材料热处理学报2019，40，4： | 8 |
| 14 | Shear strength behavior of geotextile/geomembrane interfaces显示文摘This paper aims to study the shear interaction mechanism of one of the critical geosynthetic interfaces,the geotextile/geomembrane,typically used for lined containment facilities such as landfills.A large direct shear machine is used to carry out 90 geosynthetic interface tests.The test results show a strain softening behavior with a very small dilatancy(<0.5 mm) and nonlinear failure envelopes at a normal stress range of 25-450 kPa.The influences of the micro-level structure of these geosynthetics on the macro-level interface shear behavior are discussed in detail.This study has generated several practical recommendations to help professionals to choose what materials are more adequate.From the three geotextiles tested,the thermally bonded monofilament exhibits the best interface shear strength under high normal stress.For low normal stress,however,needle-punched monofilaments are recommended.For the regular textured geomembranes tested,the space between the asperities is an important factor.The closer these asperities are,the better the result achieves.For the irregular textured geomembranes tested,the nonwoven geotextiles made of monofilaments produce the largest interface shear strength. | Belén M.Bacas Jorge Caizal Heinz Konietzky | 2015 | Journal of Rock Mechanics and Geotechnical Engineering2015，7，6： | 7 |
| 15 | 博物馆计算机技术虚拟修复与复制文物方法初探--以德国美因茨博物馆为例显示文摘随着计算机技术的迅猛发展,作为博物馆硬核的文物藏品,在保护修复、展陈及复制品制作等方面也成为IT界施展其技术的新领域。本文列举德国美因茨博物馆几个项目案例,旨在阐述文物无触碰信息采集与虚拟修复以及复制品制作等技术,作为对传统技术的有益补充,还弥补了传统修复、复制不可能实现的缺憾,对文物保护修复技术发展领域的拓宽进行了有益的尝试。 | 侯改玲 Guido Heinz | 2021 | 华夏考古2021，，1： | 7 |
| 16 | 普通型心房扑动的新现象显示文摘普通型心房扑动 (AFL)的完整折返环路以及界嵴 (CT)和AFL的关系仍不太清楚 ,笔者应用电解剖 (CARTO)标测系统执行两项研究。Ⅰ :对 12例持续AFL的病人实施右房CARTO标测及多部位拖带。于三尖瓣环 (TA)周围测量传导速度。双电位 (DP)位于右房后下壁 ,相当于解剖上的界嵴 ,从下腔静脉 (IVC)与心房肌的连接处向上、稍前延伸 ,其长度为 40 .9± 7.9mm。所有病人的DP间期从上至下逐渐增加。在 9例逆向AFL病人中 ,右心耳后基底部的后方一狭长心肌位于折返环内 ,结果来自右心耳基底前、后方的两个心房激动波融合于右房下游离壁。在另 3例病人中 (1例顺钟向、2例逆钟向 )右心耳基底部后方未发现位于折返环内 ,迫使折返环仅绕三尖瓣与右心耳基底部前方之间的心肌兴奋右房下游离壁。在AFL的折返环中 ,没有固定的缓慢传导区 ,大部分病人的缓慢传导区位于间隔部和侧壁。Ⅱ :对 7例普通型AFL及 6例非AFL病人 ,在冠状窦起搏下 ,标测右房后壁。通过在右房重建中出现DP确认CT。以 6 0 0 ,30 0ms周长以及静脉注射氟卡胺 (1mg/kg)后以 6 0 0ms周长起搏冠状窦 ,分别测量CT上、中、下部位的刺激信号至双电位中第一及第二个心房激动波的传导时间 (SD1及SD2 )和此部位的电位间期 (DPI)。在AFL病例中 ,与以 6 0 | 欧阳非凡 Karl Heinz Kuck | 2000 | 中国心脏起搏与心电生理杂志2000，14，1： | 6 |
| 17 | Transjugular intrahepatic portosystemic shunt in refractory chylothorax due to liver cirrhosis显示文摘A pleural effusion containing chylomicrons is termed chylothorax and results from leakage of lymph fluid into the pleural cavity.We report on the case of a 59-year-old woman with severe dyspnea due to a large chylothorax.She was known to have liver cirrhosis but no ascites.There was no history of trauma,cardiac function was normal and thorough diagnostic work-up did not reveal any signs of malignancy.In summary,no other etiology of the chylothorax than portal hypertension could be found.Therapy with diuretics as well as parenteral feeding failed to relieve symptoms.After a transjugular intrahepatic portosystemic shunt(TIPS) had successfully been placed,pleural effusion decreased considerably.Eight months later,TIPS revision had to be performed because of stenosis,resulting in remission from chylothorax.This case shows that even in the absence of ascites,chylothorax might be caused by portal hypertension and that TIPS can be an effective treatment option. | Philipp Lutz Holger Strunk Hans Heinz Schild Tilman Sauerbruch | 2013 | World Journal of Gastroenterology2013，19，7： | 6 |
| 18 | 土地覆盖制图:基于最优化遥感数据的支撑向量机分类(英文)显示文摘遥感数据具有在不同空间、光谱和时间尺度上获取地表测量信息的能力,使其成为获取土地覆盖信息的一个主要数据源。影像分类即把卫星影像上的相关像元划分给某类已知的土地覆盖类型的过程。支撑向量机(SVMs)是一种土地覆盖分类的新技术。三种常用的SVMs是:基于线性和多项式的SVM以及具有高斯核函数的SVM分类器,分类能否成功地应用有赖于其各自选择的最佳参数。但是海量的遥感数据使得这些参数的确定速度十分缓慢。本文研究了一种新的基于最优化遥感数据压缩技术的SVM分类方法。研究显示用于获取SVM参数的数据量能够在不影响土地覆盖的分类精度的前提下进行压缩。数据压缩成功的应用于多项式和高斯核函数的SVM分类,而线性SVM的分类精度却非常低。 | Gidudu Anthony Heinz Ruther | 2007 | 遥感学报2007，11，5： | 6 |
| 19 | Recent development in aluminium alloys for aerospace applications显示文摘 | A Heinz A Haszler C Keidel S Moldenhauer R Benedictus W.S Miller | 2000 | Materials Science & Engineering A2000，，1： | 5 |
| 20 | Seasonality in human semen quality of smokers and non-smokers: effect of temperature显示文摘Aim: To analyse the possible effect of seasonal variation on semen parameters. Methods: The participants consisted of 1688 men attending the andrology laboratory between 1991 and 1997 for reduced fertility in the couple. Semen analysis was performed according to the WHO manual. The 84 individual months of the study period were each assigned to one of the three groups according to the average monthly outside temperature; Group A (temperature <4.4 ℃), Group B (4.4 ℃ - 13.3 ℃) and Group C (>13.3 ℃). Results: When comparing the different sperm parameters, the morphology was significantly better in Group C. However, when the smokers were analysed separately, this difference disappeared and significant seasonal variations were found in sperm density, total sperm count, motility and total motile sperm; they were deteriorated in the warmer season. In non-smokers, no such negative effect of increased temperature was observed. Conclusion: Sperm quality is influenced by seasonal factors.Increased environmental temperature, (maybe also light exposure) has an additional negative effect on the spermatogenesis in smokers, leading to reduced sperm quality in men with borderline fertility. (Asian J Androl 2004 Sep; 6:243-247) | Robert Kunzle Michael D.Mueller Alexander W.Huber Heinz Drescher Nick A.Bersinger | 2004 | Asian Journal of Andrology2004，6，3： | 5 |
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