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176篇 您的检索式:作者名="HE Qun"
    题名 作者 年代 出处 被引量
1A Novel Protein RLS1 with NB-ARM Domains Is Involved in Chloroplast Degradation during Leaf Senescence in Rice显示文摘叶老朽,规划细胞死亡(PCD ) 的一种类型由叶绿素降级描绘了,是重要的种生长和庄稼生产率。autophagy 在叶老朽期间涉及叶绿体降级,这出现。然而,涉及这个过程的分子的机制很好没被理解。在这研究,米饭 rls1 (快速的叶老朽 1 ) 的基因、生理的特征异种被识别。rls1 异种开发了类似于在野类型的植物比那些显示了更早的老朽的叶子的整个表面上散布的疾病的小、黄褐的损害。在老朽期间满意的叶绿素的快速的损失是在 rls1 的加速的叶老朽的主要原因。显微镜的观察显示 PCD 被调整,可能在 rls1 导致叶绿体的加速的降级离开。RLS1 基因的基于地图的克隆表明它编码一以前在 carboxyl 终点与一个手臂(犰狳) 领域包含蛋白质的 uncharacterized NB (核苷酸绑定地点) 。与它在叶老朽的参与一致, RLS1 在导致黑暗的叶老朽期间是起来调整的并且由细胞激动素下面调整。有趣地, RLS1 的组成的表示稍微也在转基因的米饭植物与减少的叶绿素内容加速了叶老朽。我们识别的学习一以前, uncharacterized NBARM 蛋白质在植物生长和开发期间在 PCD 包含了,为把提供一个唯一的工具可能的调停 autophagy 的 PCD 在在植物的老朽期间。Bin-Bin Jiao Jian-Jun Wang Xu-Dong Zhu Long-Jun Zeng Qun Li Zu-Hua He 2012Molecular Plant2012,5,1:45
2Altered Disease Development in the eui Mutants and Eui Overexpressors Indicates that Gibberellins Negatively Regulate Rice Basal Disease Resistance显示文摘赤霉素(气体) 形成涉及植物生长和开发的许多方面的一组重要植物 tetracyclic diterpenoid 荷尔蒙。新兴的证据含有那气体也在压力回答起作用。然而,在关於生命的应力的气体的角色大部分是未知的。这里,我们报导那个大美人或 overexpression 伸长最高编码撤销的 GA 的 internode (Eui ) 基因分别地,酶损害或增加疾病抵抗到细菌的老家(Xanthomonas oryzae pv。oyrzae ) 并且米饭强风(Magnaporthe oryzae ) 。分别地, GA3 和 GA 合成(uniconazol ) 的禁止者的外长的申请能增加疾病危险性和抵抗到细菌的老家。同样, uniconazol 恢复了 eui 异种的疾病抵抗, GA3 减少了到细菌的老家的 Eui overexpressors 的疾病抵抗。因此,抵抗的变化把层次归因于 GA。在有这的一致性, GA 新陈代谢基因 OsGA20ox2 和 OsGA2ox1 在病原体挑战期间是下面调整的。我们也发现那 PR1a 正式就职被提高,但是 SA 水平在 Eui overexpressor 被减少,当 JA 水平在 eui 异种被减少时。一起,我们的当前的学习显示气体在米饭起一个否定作用基础疾病电阻,与是的 EUI 通过调整 bioactive 气体的水平的一个积极调节的人。Dong-Lei Yang Qun Li Yi-Wen Deng Yong-Gen Lou Mu-Yang Wang Guo-Xing Zhou Ying-Ying Zhang Zu-Hua He 2008Molecular Plant2008,1,3:29
3Rice RING protein OsBBI1 with E3 ligase activity confers broad-spectrum resistance against Magnaporthe oryzae by modifying the cell wall defence显示文摘新兴的证据建议 E3 ligases 在多样的生物过程起关键作用,包括在植物的天生的有免疫力的回答。然而,在植物的 E3 ligase 参与的机制天生的免疫是不清楚的。我们报导那米饭基因, OsBBI1,与 E3 ligase 活动编码戒指手指蛋白质,调停用途广泛的疾病抵抗。OsBBI1 的表示被米饭强风真菌 Magnaporthe oryzae,以及化学 inducers 导致, benzothiadiazole 和水杨酸酸。生物化学的分析表明那 OsBBI1 蛋白质在 vitro 拥有 E3 ubiquitin ligase 活动。基因分析表明在一根 Tos17 插入线的 OsBBI1 功能的损失增加了危险性,当在转基因的植物的 OsBBI1 的 overexpression 授与提高的抵抗到 M 的多重赛跑时。oryzae。这显示 OsBBI1 对强风真菌调制用途广泛的抵抗。OsBBI1-overexpressing 植物由 M 在感染地点在房间墙中在酉分的混合物的房间和蛋白质的 cross-linking 显示出 H2O2 累积的高水平。oryzae 与相比野类型(WT ) 植物。房间墙在 OsBBI1-overexpressing 植物是更厚的并且在变异的植物更薄比在 WT 植物。我们的结果建议 OsBBI1 由修改房间墙防卫回答调制用途广泛的抵抗到强风真菌。OsBBI1 的功能的描述为在米饭对最破坏的疾病构造用途广泛的抵抗提供卓见进 E3 调停 ligase 的天生的免疫,和一个实际工具。Wei Li Sihui Zhong Guojun Li Qun Li Bizeng Mao Yiwen Deng Huijuan Zhang Longjun Zeng Fengming Song Zuhua He 2011Cell Research2011,21,5:30
4Spatiotemporal dynamics of electric power consumption in Chinese Mainland from 1995 to 2008 modeled using DMSP/OLS stable nighttime lights data显示文摘电力消费(EPC ) 是为评估电力使用的基本索引之一。在 EPC 的空间与时间的动力学上获得及时、精确的数据为理解和电力资源的实际推广是关键的。在这研究,一个 EPC 模型从防卫气象学的卫星程序用稳定的夜间灯时间系列数据被开发运作的 Linescan 系统(DMSP/OLS ) 。模型被用来重建在在县的中国大陆的 EPC 的空间模式从 1995 ~ 2008 铺平。另外, EPC 的空间与时间的动力学被分析,并且下列结论被得出。(1 ) EPC 模型可靠地与约 70% 精确性在中国大陆代表了 EPC 的空间与时间的动力学。(2 ) 在中国大陆的大多数区域的 EPC 在对中等层次低,与显著时间、空间的变化;高级 EPC, 58.26% 在东方中国被集中。六城市的凝块(Beijing-Tianjin-Tangshan 区域, Shanghai-Nanjing-Hangzhou 区域,珀尔河三角洲,山东半岛,辽宁省,和四川盆中间南方) 说明了中国大陆的 10.69% 全部的区域,但是消费了 39.23% 电。(3 ) 在从 1995 ~ 2008,和 64% 大陆区域增加的中国大陆的大多数区域的 EPC 在 EPC 显示出重要增加。EPC 的中等增加从 1995 ~ 2008 在 61.62% 东方中国和 80.65% 华中被发现,而 75.69% 西方的中国没在 EPC 显示出重要增加。同时,分别地, 77.27% , 89.35% ,和 66.72% Shanghai-Nanjing-Hangzhou 区域,珀尔河三角洲,和山东半岛在 EPC 显示出高速度的增加。EPC 的中等增加发生在 71.12% Beijing-Tianjin-Tangshan 区域和 72.13% 并且辽宁省中间南方,分别地当没有重要增加发生在 56.34% 四川盆时。HE Chunyang MA Qun LI Tong YANG Yang LIU Zhifeng 2012Journal of Geographical Sciences2012,22,1:25
5Control of Rice Embryo Development, Shoot Apical Meristem Maintenance, and Grain Yield by a Novel Cytochrome P450显示文摘被子植物种子通常由二主要部分组成:胚胎和内乳。然而,分子的机制 underlyingembryo 和内乳发展仍然保持大部分未知,特别地在米饭,模型谷物。这里,我们报导 identificationand 米饭巨人胚胎(GE ) 基因的功能的描述。GE 的变化在种子导致了一个大胚胎,它被胚鳞房间的过多的扩大引起。embryonic 以后 growthof ge 幼苗严重地由于有缺点的射击被禁止顶端的分裂组织(SAM ) 维护。基于地图的克隆表明 thatGE 编码对 endoplasmic 蜂窝胃局部性的 CYP78A 亚科 P450 monooxygenase。GE 在 scutellar 上皮主要被表示,在胚胎和内乳之间的接口区域。Overexpressionof GE 支持了细胞增长并且提高了米饭植物生长和谷物产量,但是减少了胚胎尺寸,建议 GE 为协调米饭胚胎和内乳开发是批评的。而且,转基因的 Arabidopsis 植物 overexpressing AtCYP78A10,一个 GE 相当或相同的事物,也生产的更大的种子,在一起调整种子 development.Taken 为 P450s 的 CYP78A 亚科暗示一个保存角色,我们的结果显示 GE 在调整胚胎发展和 SAM maintenance.Key 词起关键作用:Weibing Yang Mingjun Gao Xin Yin Jiyun Liu Yonghan Xu Longjun Zeng Qun Li Shubiao Zhang Junmin Wang Xiaoming Zhang Zuhua He 2013Molecular Plant2013,6,6:16
6深厚软土桥梁桩基荷载传递特性及沉降控制效果研究显示文摘通过杭甬铁路客运专线柯桥特大桥单桩静载试验,桩身应变、桩身压缩量及桥墩沉降的测试,研究深厚软土地区桥梁桩基的荷载传递特性及沉降控制效果。结果表明:桩侧摩阻力先于桩端阻力发挥作用;尽管桩端置于强风化凝灰质砂岩上,但在试验荷载下2根超长试验桩的端承比均小于1.5%,桩的承载特性表现为摩擦桩的性质;单桩静载试验实测的桩身压缩量占桩顶沉降量的85%以上;桥墩浇筑完成后经过753d的沉降观测,2个试验墩实测沉降量分别为3.00和3.41mm,其中,无砟轨道铺设后300d的实测沉降分别为0.11和0.25mm,表明在深厚软土地区采用超长钻孔灌注桩控制桥梁基础沉降的效果显著。 Xin, Xuezhong Wei, Limin He, Qun 2012中国铁道科学2012,,4:15
7Proteomic Analysis of Rice Plasma Membrane-associated Proteins in Response to Chitooligosaccharide Elicitors显示文摘Chitooligomers 或 chitooligosaccharides (公司) 是得到 ors 绑在质膜(下午) 并且得到各种各样的防卫回答。然而,涉及调停 elicitor 的植物防卫回答的下午界限蛋白质仍然保持广泛地未知。为了关于下午蛋白质得到更多的信息,在米饭防卫回答包含了,我们进行了公司得到的米饭暂停房间的下午 proteomic 分析 14 的一个总数在上面--或调整蛋白质看到的down 在公司孵化以后在 12 h 和 24 h 在下午部分的 2-D 胶化上被观察。他们,八个蛋白质点被 MS (集体摄谱仪使用法)成功地识别并且预言了在植物防卫被联系到 PM 和功能,包括通常认为的 PKN/PRK1 蛋白激酶,通常认为的 pyruvatekinase isozyme G ,通常认为的锌手指蛋白质,通常认为的3月绑定蛋白质 MFP1 ,并且通常认为的钙依赖者蛋白激酶。有趣地,导致公司的象 pM5 一样蛋白质在植物第一次被识别,它是 transmembrane 在转变生长因素的节的调节的人 -- 在脊椎动物发信号的贝它(TGF 贝它) 。我们也识别了一个 ricepolyprotein 家庭的二个成员,它由我们的学习将提供的公司是起来调整的为在米饭的下午蛋白质的功能的一个起点基础防卫……Fang Chen Qun Li Zuhua He 2007Journal of Integrative Plant Biology2007,49,6:12
8Simulation on the dynamics of forest area changes in Northeast China显示文摘There is plenty of forests in Northeast China which contributes a lot to the conservation of water and land resources, produces timber products, and provides habitats for a huge number of wild animals and plants. With changes of socio-economic factors as well as the geophysical conditions, there are dramatic changes on the spatial patterns of forest area. In this sense, it is of great significance to shed light on the dynamics of forest area changes to find the underlining reasons for shaping the changing patterns of forest area in Northeast China. To explore the dynamics of forest area change in Northeast China, an econometric model is developed which is composed of three equations identifying forestry production, conversion from open forest to closed forest and conversion from other land uses to closed forest so as to explore the impacts on the forest area changes from demographic, social, economic, location and geophysical factors. On this basis, we employ the Dynamics of Land System (DLS) model to simulate land-use conversions between forest area and non-forest cover and the land-use conversions within the sub-classes of forest area for the period 2000–2020 under business as usual scenario, environmental protection scenario and economic growth scenario. The simulation results show that forest area will expand continuously and there exist various kinds of changing patterns for the sub-classes of forest area, for example, closed forest will expand continuously and open forest and shrub will decrease a little bit, while area of other forest will keep intact. The research results provide meaningful decision-making information for conserving and exploiting the forest resources and making out the planning for forestry production in the Northeast China region.DENG Xiangzheng JIANG Qun'ou ZHAN Jinyan HE Shujin LIN Yingzhi 2010Journal of Geographical Sciences2010,20,4:11
9Gibberellin homeostasis and plant height control by EUI and a role for gibberellin in root gravity responses in rice显示文摘米饭 Eui (伸长最高节间) 基因编码撤销的细胞色素 P450 monooxygenase 简历活跃赤霉素(气体) 。在这研究,我们在植物开发调查了 Eui 基因和它的角色的控制表示。我们发现 Eui 是外长的气体导致的差别并且 Eui 倡导者在维管束举办了最高的活动。eui 异种在在根冠的淀粉小粒开发是有缺点的,在表达式上的 Eui 提高了淀粉小粒产生和严肃回答,揭示为在根淀粉小粒开发和严肃回答的 GA 的一个角色。使用胚胎更少一半种子的实验揭示了那 RAmy1A, GAmyb 是高度起来当外长的 GA 不在时在 eui 糊粉房间调整了。另外, GA 生合成基因 GA3ox1 和 GA20ox2 是调整的 down, GA2ox1 起来在 eui 调整了幼苗。这些结果显示 EUI 涉及 GA 动态平衡,不是在仅仅内部在出发阶段的节点,而且在苗期,根和种子。扰乱 GA 动态平衡影响了表明基因 GID1 (赤霉素感觉迟钝的矮子 1 ) 的 GA 的表示, GID2 和 SLR1。有效地增加的 Eui 基因的转基因的 RNA 干扰种高度和改进标题性能。由对比,在米饭 GA 生合成基因 GA3ox2 和 GA20ox2 的倡导者下面的 Eui 的宫外的表示显著地减少了植物高度。这些结果证明 Eui 表示的细微增加能戏剧性地改变米饭形态学,显示在米饭的 Eui 基因的实际申请为一个高产潜力的分子的繁殖。Yingying Zhang Yongyou Zhu Yu Peng Dawei Yan Qun Li Jianjun Wang Linyou Wang Zuhua He 2008Cell Research2008,18,3:10
10An H3K27me3 demethylase-HSFA2 regulatory loop orchestrates transgenerational thermomemory in Arabidopsis显示文摘Global warming has profound effects on plant growth and fitness.Plants have evolved sophisticated epigenetic machinery to respond quickly to heat,and exhibit transgenerational memory of the heat-induced release of post-transtriptional gene silencing(PTGS).However,how thermomemory is transmitted to progeny and the physiological relevance are elusive.Here we show that heat-induced HEAT SHOCK TRANSCRIPTION FACTOR A2(HSFA2)directly activates the H3K27me3 demethylase RELATIVE OF EARLY FLOWERING 6(REF6),which in turn derepresses HSFA2.REF6 and HSFA2 establish a heritable feedback loop,and activate an E3 ubiquitin ligase,SUPPRESSOR OF GENE SILENCING 3(SGS3)-INTERACTING PROTEIN 1(SGIP1).SGIP1-mediated SGS3 degradation leads to inhibited biosynthesis of trans-acting siRNA(tasiRNA).The REF&HSFA2 loop and reduced tasiRNA converge to release HEAT-INDUCED TAS1 TARGET 5(HTT5),which drives early flowering but attenuates immunity.Thus,heat induces transmitted phe no types via a coordi nated epigenetic network involvi ng histone demethylases,tran scriptio n factors,and tasiRNAs,ensuring reproductive success and transgenerational stress adaptation.Junzhong Liu Lili Feng Xueting Gu Xian Deng Qi Qiu Qun Li Yingying Zhang Muyang Wang Yiwen Deng Ertao Wang Yuke He Isabel Baurle Jianming Li Xiaofeng Cao Zuhua He 2019Cell Research2019,29,5:10
11Plasma Membrane Localization and Potential Endocytosis of Constitutively Expressed XA21 Proteins in Transgenic Rice显示文摘米饭模式识别受体(PRR ) XA21 由细菌的老家 Xathomonas oryzae pv 在叶感染授与赛跑特定的抵抗。oryzae (Xoo ) ,并且被显示对 endoplasmic 蜂窝胃主要局部性(嗯) 当在原物与它的本国的倡导者或 overexpressed 一起表示了时。然而,当 overexpressed 尚待被鉴别时,蛋白质是否仍然是在未经触动的房间的嗯本地化。这里,我们显示出那 XA21,它的 kinase 死了的变异的 XA21PK736EP,和熔化主要是的三倍的 autophosphorylation 异种 XA21PS686A/T688A/S699A GFP 对血浆膜(下午) 局部性什么时候在未经触动的转基因的米饭房间的 overexpressed,并且对在转基因的原物的 ER 也局部性。组成地表示野类型的 XA21 或它的 GFP 熔化的转基因的植物在成年人和幼苗阶段显示了赛跑特定的抵抗到 Xoo。XA21 和 XA21PK736EP 能在原物经由流氓积极的早 endosomal 分隔空间可能被使内在化,建议 XA21 可能是开始在病原体感染期间的抵抗回答的 endocytosed。我们也建立了一个根感染系统并且表明了那 XA21 对在根的 Xoo 的也调停的赛跑特定的抵抗回答。我们的当前的学习用根房间系统提供卓见进调停 XA21 的电阻和一条实际途径的性质进一步把在 riceXoo 相互作用期间的 PRR 的细胞的发信号。Fang Chen Ming-Jun Gao Yan-Song Miao Yue-Xing Yuan Mu-Yang Wang Qun Li Bi-Zeng Mao Li-Wen Jiang Zu-Hua He 2010Molecular Plant2010,3,5:9
12Fetal reduction by bipolar cord coagulation in managing complicated monochorionic multiple pregnancies: preliminary experience in China显示文摘背景 Monochorionic 多重怀孕(MMP ) 与 interfetal 引起的 perinatal 病态和死亡的更高的率被联系脉管在 monochorionic 胎盘吻合,它能导致胎儿的健康相互作用。在一些情形,影响胎儿的选择杀胎是必要的节省健康合作双胞胎。我们为复杂 MMP 的管理用双极的绳索凝结评估了我们的起始的经验的效果和安全。用指导超声的双极的绳索凝结的方法,我们在 14 复杂 MMP 上执行了选择杀胎(5 与成双双胞胎的输送症候群, 4 与 acardia, 3 与不和的结构的异例,并且 2 与严重选择子宫内的生长限制) 。有 monochorionic 三位字节的一个病人收到了过程两次为不同指示终止 2 个影响胎儿。关于操作,复杂并发症和新生的结果的数据被分析。结果绳索吸藏成功地在 13/14 (93%) 被执行盒子。失败在一个 acardiac 胎儿发生了,怀孕被正式就职终止。与 perinatal 幸存在 35.4 个星期的吝啬的 gestational 年龄交付的包括的盒子 11/13 (85%) 评价。三操作相关的复杂并发症发生了(21%) 包括终止的囊(1 个盒子) 的膜破裂,在 28 星期怀孕期(1 个盒子) 的 preterm 劳动,和 chorioamniotic 膜分离(1 个盒子) 。Amnioinfusion 在 11 过程被显示为进入套管针并且获得足够的工作空间扩展目标囊。在 acardia 的所有 4 个盒子中,然而, acardiac 囊显示出极端 oligohydramnios 并且不能被注入很好扩展;因此,套管针不得不从保存合作双胞胎的囊被插入。在复杂 MMP 的双极的绳索凝结的申请是保险箱并且改进预后的结论。Amnioinfusion 在当工作空间是有限的时,帮助扩展目标囊是有用的。HE Zhi-ming FANG Qun YANG Yong-zhong LUO Yan-min CHEN Jun-hong CHEN Yong-zhen ZHOU Yi CHEN Min-ling 2010Chinese Medical Journal2010,,5:9
13A DELLA protein complex controls the arbuscular mycorrhizal symbiosis in plants显示文摘Nan Yu Dexian Luo Xiaowei Zhang Junzhong Liu Wanxiao Wang Yue Jin Wentao Dong Jiyun Liu Huan Liu Weibing Yang Longjun Zeng Qun Li Zuhua He Giles E D Oldroyd Ertao Wang 2014Cell Research2014,24,1:9
14Assessing validation of dual fluoroscopic image matching method for measurement of in vivo spine kinematics显示文摘针的结构的功能的背景精确知识是批评的理解影响针的病理的 biomechanical 因素。许多研究在 vitro 并且在 vivo.However 调查了人的脊椎的运动,决心在 vivo ,在生理的装载条件下面的 vertebrae 的运动在因为当前的技术的限制和 spine.Methods 的复杂解剖的生物医学的设计为仍然是挑战在 vitro 确认,一个人的腰部的标本与钢祷告是嵌入的并且由一台通用测试机器( UTM )搬到已知的距离。双 fluoroscopic 系统被用来捕获脊骨运动并且复制动人的距离。为在 vivo 确认,当忍受重量时,一个生活题目在各种各样的位置移动了脊骨。荧光屏被用来复制在里面 vivo 脊骨位置 5 次。在五大小的翻译和取向的标准差被用来评估技术的重覆性。脊椎的轮廓与匹配技术的金属性的标记匹配的精确性是 compared.Results 人的腰部的标本的翻译位置能与吝啬的精确性被决定不到 0.35 公里和吝啬的重覆性为匹配的图象的 0.36 公里技术。在在自由(6DOF ) 的 vivo 人脊骨六度复制 kinematics 的方法的重覆性是在翻译的不到 0.43 公里并且不到 0.65 ?????? 吗??BAI Jian-qiang HU Yong-cheng DULi-qing HE Jing-liang LIU Kai LIU Zhongjun XIA Qun 2011Chinese Medical Journal2011,,11:9
15Modified joint probabilistic data association with classification-aided for multitarget tracking显示文摘Joint probabilistic data association is an effective method for tracking multiple targets in clutter, but only the target kinematic information is used in measure-to-track association. If the kinematic likelihoods are similar for different closely spaced targets, there is ambiguity in using the kinematic information alone; the cor-rect association probability will decrease in conventional joint probabilistic data association algorithm and track coalescence will occur easily. A modified algorithm of joint probabilistic data association with classification-aided is presented, which avoids track coalescence when tracking multiple neighboring targets. Firstly, an identification matrix is defined, which is used to simplify validation matrix to decrease computational complexity. Then, target class information is integrated into the data association process. Performance comparisons with and without the use of class information in JPDA are presented on multiple closely spaced maneuvering targets tracking problem. Simulation results quantify the benefits of classification-aided JPDA for improved multiple targets tracking, espe-cially in the presence of association uncertainty in the kinematic measurement and target maneuvering. Simulation results indicate that the algorithm is valid.Ba Hongxin Cao Lei He Xinyi Cheng Qun 2008Journal of Systems Engineering and Electronics2008,19,3:8
16Effect of rGO Coating on Interconnected Co_3O_4 Nanosheets and Improved Supercapacitive Behavior of Co_3O_4/rGO/NF Architecture显示文摘In this study, the effect of reduced graphene oxide(rGO) on interconnected Co_3O_4 nanosheets and the improved supercapacitive behaviors is reported. By optimizing the experimental parameters, we achieved a specific capacitance of ~1016.4 F g^(-1) for the Co_3O_4/rGO/NF(nickel foam) system at a current density of 1 A g^(-1). However, the Co_3O_4/NF structure without rGO only delivers a specific capacitance of ~520.0 F g^(-1)at the same current density. The stability test demonstrates that Co_3O_4/rGO/NF retains ~95.5% of the initial capacitance value even after 3000 charge–discharge cycles at a high current density of 7 A g^(-1). Further investigation reveals that capacitance improvement for the Co_3O_4/rGO/NF structure is mainly because of a higher specific surface area(~87.8 m^2g^(-1))and a more optimal mesoporous size(4–15 nm) compared to the corresponding values of 67.1 m^2g^(-1) and 6–25 nm,respectively, for the Co_3O_4/NF structure. rGO and the thinner Co_3O_4 nanosheets benefit from the strain relaxation during the charge and discharge processes, improving the cycling stability of Co_3O_4/rGO/NF.Tinghui Yao Xin Guo Shengchun Qin Fangyuan Xia Qun Li Yali Li Qiang Chen Junshuai Li Deyan He 2017Nano-Micro Letters2017,9,4:8
17Protective effect of Saccharomyces boulardii on intestinal mucosal barrier of dextran sodium sulfate-induced colitis in mice显示文摘Background: The effect and mechanism of Saccharomyces boulardii (Sb) in inflammatory bowel disease are unclear. The objective of the study was to evaluate the impact of Sb on intestinal mucosal barrier and intestinal flora in a colitis mouse model. Methods: Forty C57BL/6J male mice were randomly assigned to five groups: normal control group (A), pathologic control group (B), Sb treatment group (C), mesalazine treatment group (D), and Sb combined with mesalazine treatment group (E). Colitis was induced by the addition of 2.5%(wt/vol) dextran sodium sulfate (DSS) in the drinking water ad libitum for 7 days. The general condition, weight change, stool property, and bloody stool level of mice were observed to evaluate the disease activity index. The expression of zona occludens-1 (ZO-1) and occludin in intestinal tissue were measured by immunohistochemistry. The level of tumor necrosis factor-α(TNF-α) and interleukin (IL)-8 in plasma was measured by enzyme linked immunosorbent assay. Inter-cellular tight junctions were observed by transmission electron microscopy. The feces and intestinal contents were collected sterilely, and intestinal flora was analyzed by 16S rRNA sequencing. Results: Compared with group B, Sb reduced the disease activity index and histological score of group C (disease activity index: group B 2.708 ± 0.628, group C 1.542 ± 0.616, PBC = 0.005;histological score: group B 9.875 ± 3.271, group C 4.750 ± 1.832, PBC = 0.005) in DSS-induced colitis in mice. Sb exerted a protect effect on the expression of ZO-1 (group B 2.075 ± 1.176, group C 4.225 ± 1.316, PBC = 0.019) and occludin (group B 2.200 ± 0.968, group C 3.525 ± 1.047, PBC = 0.023). Compared with group B, Sb decreased the level of TNF-α and IL-8 of group C (TNF-α: group B 716.323 ± 44.691 ng/L, group C 521.740 ± 90.121 ng/L, PBC = 0.001;IL-8: group B 128.992 ± 11.475 pg/mL, group C 106.283 ± 15.906 pg/mL, PBC = 0.012). Treatment with Sb preserved the tight junctions and ameliorated microvilli and inter-cellular space. Treatment with Sb also showed its own characteristics: a higher percentage of Bacteroidetes and a lower percentage of Firmicutes, with significant differences or a significant trend. The proportion of the S24-7 family was increased significantly in the Sb treatment group. Conclusions: Sb shows an anti-inflammatory effect and has a protective effect on the intestinal mucosal mechanical barrier. Sb may up-regulate the abundance of family S24-7 specifically, and maybe a mechanism underlying its function.Jin-Pei Dong Yue Zheng Ting Wu Qun He Gui-Gen Teng Hua-Hong Wang 2019Chinese Medical Journal2019,,16:7
18Unsaturated-sulfur-rich MoS2 nanosheets decorated on free-standing SWNT film: Synthesis, characterization and electrocatalytic application显示文摘此处,我们报导一条自底向上的 solvothermal 线路综合为氢进化反应的灵活、高度有效的瞬间 2@SWNT electrocatalyst (她的) 。描述表明包含 sulfurrich 地点的像分支的瞬间 2 nanosheets 在一致地在自立的围单人赛的碳 nanotube (SWNT ) 上驱散的 situ 电影,能暴露更不饱和的硫原子,与活跃地点允许优秀电的接触。展出的灵活催化剂优秀她有低过电位的表演(~ 在 10 妈 / 厘米 2) 和小 Tafel 斜坡(41 mV/dec ) 的 150 mV。为了推进,解释改进表演,本地电子结构被 X 光检查吸收调查近边的结构(XANES ) 分析,证明不饱和的硫原子并且在瞬间 2 和 SWNT 之间的强壮的电子联合的存在。这研究提供一条在原处合成的线路在催化剂微观结构,电子结构,和性质之中创造新多功能的灵活 hybridized 催化剂和有用卓见进关系。Daobin Liu Weiyu Xu Qin Liu Qun He Yasir A. Haleem Changda Wang Ting Xiang Chongwen Zou Wangsheng Chu Jun Zhong Zhiqiang Niu Li Song 2016Nano Research2016,9,7:7
19Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy显示文摘在这研究,我们在场有 NH 4+2 ultrathin nanosheets 的准备 > 用一个自底向上的热水的方法和在导致光的 photothermal 癌症的这材料的潜在的申请的置闰治疗。我们的结果表明有 150 nm 的一种尺寸的 nanosheets 在宽广在红外线附近的波长区域是高度吸水、展出的强壮的轻吸收和优秀 photostability。在里面 vitro 试验性的结果显示了 nanosheets 的好 biocompatibility。更尤其是,我们的在里面 vivo antitumor 实验说明了从有 808 nm 激光的 2 nanosheets 能高效地杀死的 1T-WS 的照耀发源的那导致光的 photothermal 脱离肿瘤房间;这些效果不仅在细胞的水平而且在老鼠的生活机关被获得。这结果可以在新奇 photothermal 治疗导致二维的分层的材料的新应用,另外的 photothermal 联系领域。Qin Liu Chunyang Sun Qun He Adnan Khalil Ting xiang Daobin Liu Yu Zhou Jun Wang Li Song 2015Nano Research2015,8,12:6
20Estimation of Land Production and Its Response to Cultivated Land Conversion in North China Plain显示文摘Food safety and its related influencing factors in China are the hot research topics currently,and cultivated land conversion is one of the significant factors influencing food safety in China.Taking the North China Plain as the study area,this paper examines the changes of cultivated land area using satellite images,estimates land productivity from 1985 to 2005 using the model of Estimation System for Land Productivity(ESLP),and analyzes the impact of cultivated land conversion on the land production.Compared with the grain yield data from statistical yearbooks,the results indicate that ESLP model is an effective tool for estimating land productivity.Land productivity in the North China Plain showed a slight decreasing trend from 1985 to 2005,spatially,increased from the north to the south gradu-ally,and the net changes varied in different areas.Cultivated land area recorded a marginal decrease of 8.0 × 105 ha,mainly converted to other land uses.Cultivated land conversion had more significant negative impacts on land produc-tion than land productivity did.Land production decreased by about 6.48 × 106 t caused by cultivated land conversion between 1985 and 2005,accounting for 91.9% of the total land production reduction.Although the land productivity increased in Anhui and Jiangsu provinces,it can not offset the overall adverse effects caused by cultivated land con-version.Therefore,there are significant meanings to control the cultivated land conversion and improve the land pro-ductivity for ensuring the land production in the North China Plain.JIANG Qun'ou DENG Xiangzheng ZHAN Jinyan HE Shujin 2011Chinese Geographical Science2011,21,6:6
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