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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Correlation of matrix metalloproteinase suppressor genes RECK,VEGF,and CD105 with angiogenesis and biological behavior in esophageal squamous cell carcinoma显示文摘AIM: To explore the expression of reversion inducing cysteine-rich protein with Kazal motifs (RECK), vascular endothelial growth factor (VEGF) and endoglin (CD105) protein and its correlation with occurrence, development, invasion and metastasis in esophageal squamous cell carcinoma (ESCC). METHODS: Streptavidin-peroxidase (SP) immunohisto- chemistry was used to detect expression of RECK and VEGF in 62 cases of ESCC, 31 cases of adjacent atypical hyperplastic epithelium and 62 cases of normal esophageal epithelium. CD105 Mb was used to assess microvessel density (MVD). RESULTS: The expression of RECK was closely correlated with histological grade, infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK decreased during cancer development: normal esophageal epithelium (85.5%, 53/62), adjacent atypical hyperplastic epithelium (71.0%, 22/31), and carcinoma (59.7%, 37/62). There was a significant difference among the groups (P < 0.05). The expression of VEGF protein was closely correlated with infiltrative depth and lymphatic metastasis in ESCC (P < 0.05). The expression of VEGF protein increased during cancer development: normal esophageal epithelium (29.0%, 18/62), adjacent atypical hyperplastic epithelium (54.8%, 17/31), and carcinoma (67.7%, 42/62). There was a significant difference among the groups (P < 0.05). MVDCD105 increased in accordance with histological grade, butthere was no significant difference (grade Ⅰ, 36.92 ± 10.85; grade Ⅱ, 37.65 ± 9.50; and grade Ⅲ, 38.06 ± 12.19). The MVDCD105 was closely correlated with infiltration and lymphatic metastasis in ESCC (P < 0.05). The expression of RECK was inversely correlated with the expression of VEGF and CD105. CONCLUSION: RECK, VEGF and CD105 play important roles in the infiltration, metastasis and carcinogenesis in esophageal carcinoma. Angiogenesis in ESCC may be promoted by over-expression of CD105. | Sheng-Lei Li, Zhi-Hua Zhao, Dong-Ling Gao, Zong-Wen Liu, Qiu-Min Zhao, Jin-Xia Yu, Kui-Sheng Chen, Yun-Han Zhang, Department of Pathology, The First Affiliated Hospital Zhengzhou University He’nan Key Laboratory of Tumor Pathology, Zhengzhou 450052, He’nan Province, China | 2007 | World Journal of Gastroenterology2007，13，45： | 30 |
| 3 | OsCERK1-Mediated Chitin Perception and Immune Signaling Requires Receptor-like Cytoplasmic Kinase 185 to Activate an MAPK Cascade in Rice显示文摘保存联系病原体的分子的模式(PAMP ) 例如几丁质,被在激活 mitogen 的蛋白质 kinase (MAPK ) 的快速的激活串联的宿主细胞表面和扳机定位的模式识别受体(PRR ) 察觉,它为植物抵抗被要求到病原体。然而,到在植物的 MAPK 激活的从 PAMP 感觉的直接连接仍然保持大部分未知。在这研究,我们发现联系 PRR 的像受体的细胞质的 kinase Oryza sativa RLCK185 播送到通过和 MAPK kinase kinase 的相互作用表明串联的 MAPK 的从 PAMP 受体 OsCERK1 的有免疫力的发信号, OsMAPKKK,它是 MAPK 串联的起始的 kinase。OsRLCK185 交往与并且 phosphorylates OsMAPKKK 的 C 终端规章的领域。phosphomimetic OsRLCK185 和 OsMAPKKK 的 Coexpression 在 Nicotiana benthamiana 叶子激活 MAPK3/6 phosphorylation。而且, OsMAPKKK 交往与并且 phosphorylates OsMKK4,关键 MAPK kinase 那 transduces 几丁质信号。OsMAPKKK 的 Overexpression 增加导致几丁质的 MAPK3/6 激活,而 OsMAPKKK 击倒的妥协导致几丁质的 MAPK3/6 激活和抵抗到米饭强风真菌。一起拿,我们的结果在米饭从房间表面几丁质感觉建议一条发信号 phospho 小径的存在到 MAPK 串联的细胞内部的激活。 | Chao Wang Gang Wang Chi Zhang Pinkuan Zhu Huiling Dai Nan Yu Zuhua He Ling Xu Ertao Wang | 2017 | Molecular Plant2017，10，4： | 27 |
| 4 | Nutritional and medicinal characteristics of Chinese giant salamander (Andrias davidianus) for applications in healthcare industry by artificial cultivation: A review显示文摘Andrias davidianus,i.e.Chinese giant salamander(CGS),is one of the largest and oldest amphibians existing in the world and is also one of the valuable biological resources of China.Wild CGS has been threatened with extinction in the past decades due to over capturing,deterioration of natural environment,the slow breeding and growth of the wild species in nature.However,in the past twenty years,with the breakthrough and progress of artificial breeding technology by artificial insemination,the number of artificially cultivated CGS has increased rapidly.Artificially cultivated CGS can either be released to the CGS living environment to increase the population in nature or legally applied in food and medicinal industry as a feedstock due to the unique nutritional and medicinal values of CGS as recorded historically.In this review,the nutritional components,bioactive components and medicinal activities of the artificially cultivated CGS will be summarized.The mucus,skin,meat and bone of CGS contain many different bioactive substances thereby having various medicinal activities including anti-aging,anti-fatigue,anti-tumor,therapy of burn and anti-infection and other physiological functions.This paper will further discuss the potential applications of the artificially cultivated CGS in healthcare industry and prospects of future technological development. | Dong He Wenming Zhu Wen Zenga Jun Lin Yang Ji Yi Wang Chong Zhang Yuan Lu Daoquan Zhao Nan Su Xin-Hui Xing | 2018 | Food Science and Human Wellness2018，7，1： | 28 |
| 5 | The Property of Solution of a Nonstationary Forest Evolution System | WANG Dingjiang Department of Mathematics, Pingdingshan Teacher’s College, He’nan 467000ZHANG Yufeng Department of Mathematics, Yanbian Teacher’s College, Jilin 133000 | 1993 | Systems Science and Systems Engineering1993，3，3： | 23 |
| 6 | Land Use Change and Anthropogenic Driving Forces:A Case Study in Yanhe River Basin显示文摘Human activities alter land use patterns and affect landscape sustainability. It is therefore very important to investigate the relationship between land use change and human activities. This study focuses on the detection of changing land use patterns in the Yanhe River Basin in northern Loess Plateau of China between 1995 and 2008. Landscape metrics were used to analyze the changing land use patterns and to explore the related anthropogenic driving forces. Results show that:1) Totally, 186 590 ha of croplands were converted into alternate land-use types (equivalent to 61.7% of the original cropland area). The majority of cropland areas were found to be converted into grassland and woodland areas (accounting for 55.9% and 4.9% respectively of the original cropland areas). 2) Both cropland and woodland demonstrated an increasing fragmentation tendency while grasslands showed a decreasing fragmentation tendency. 3) Multiple driving forces of land use change were thought to act together to changes in landscape metrics in the Yanhe River Basin. The anthropogenic driving forces were analyzed from four perspectives:ecological conservation policy, labor force transfer, industrial development, and rural settlement. The policy of the GfG (Grain for Green) project was the main driving factor which expedited the conversion from cropland to woodland and grassland. Industrial development was also found to affect land use change through the direct impact of economic activities such as oil exploration and agricultural production, or through indirect impacts such as the industrial structures readjustment. Labor force transfer from rural to urban areas was found to follow the industrial structure readjustment and further drove land use change from cropland to off-farm land use. Establishment of new tile-roofed houses instead of cave-type dwellings in rural settlements has helped to aggregate the original scattered land-use type of construction. | SU Changhong FU Bojie LU Yihe LU Nan ZENG Yuan HE Anna Halina LAMPARSKI | 2011 | Chinese Geographical Science2011，21，5： | 18 |
| 7 | Chemical constituents,biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver显示文摘Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate of E.ulmoides Oliv.is still very low,only bark has been used as medicine and other parts of Eucommia ulmoides Oliv.cannot be fully utilized,even the leaves have been well utilized in food products in Japan in the past decades.In order to improve the comprehensive utilization efficiency of E.ulmoides Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of E.ulmoides Oliv.The findings suggest that other parts of E.ulmoides Oliv.could replace the bark of E.ulmoides Oliv.to some extent besides of their respective applications.The unique and extensive physiological functions between different parts of E.ulmoides Oliv.indicate that the comprehensive utilization of E.ulmoides Oliv.has a wide space to develop,which is also an effective way to protect E.ulmoides Oliv.resources and improve its the utilization rate. | Yi-Fan Xing Dong He Yi Wang Wen Zeng Chong Zhang Yuan Lu Nan Su Yan-Hua Kong Xin-Hui Xing | 2019 | Food Science and Human Wellness2019，8，2： | 18 |
| 8 | Full-thickness tissue engineered skin constructed with autogenic bone marrow mesenchymal stem cells显示文摘To explore the feasibility of repairing clinical cutaneous deficiency, autogenic bone marrow mesen-chymal stem cells (BMSCs) were isolated and differentiated into epidermal cells and fibroblasts in vitro supplemented with different inducing factors and biomaterials to construct functional tissue- engineered skin. The results showed that after 72 h induction, BMSCs displayed morphologic changes such as typical epidermal cell arrangement, from spindle shape to round or oval; tonofibrils, melano-somes and keratohyaline granules were observed under a transmission electronic microscope. The differentiated cells expressed epidermal stem cell surface marker CK19 (59.66% ± 4.2%) and epidermal cells differentiation marker CK10. In addition, the induced epidermal cells acquired the anti-radiation capacity featured by lowered apoptosis following exposure to UVB. On the other hand, the collagen microfibrils deposition was noticed under a transmission electronic microscope after differentiating into dermis fibroblasts; RT-PCR identified collagen type I mRNA expression in differentiated cells; radioimmunoassay detected the secretion of interleukin-6 (IL-6) and interleukin-8 (IL-8) (up to 115.06 pg/mL and 0.84 ng/mL, respectively). Further in vivo implanting BMSCs with scaffold material short-ened skin wound repair significantly. In one word, autogenic BMSCs have the potential to differentiate into epidermal cells and fibroblasts in vitro, and show clinical feasibility acting as epidermis-like and dermis-like seed cells in skin engineering. | HE LiJuan, NAN Xue, WANG YunFang, GUAN LiDong, BAI CiXian, SHI ShuangShuang, YUAN HongFeng, CHEN Lin, LIU DaQing & PEI XueTao Laboratory of Stem Cells and Regenerative Medicine, Institute of Blood Transfusion, Academy of Military Medical Sciences, Beijing 100850, China | 2007 | Science China(Life Sciences)2007，50，4： | 16 |
| 9 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 10 | MdGSTF6,activated by MdMYB1,plays an essential role in anthocyanin accumulation in apple显示文摘Anthocyanins are biosynthesized on the cytosolic surface of the endoplasmic reticulum and then transported into the vacuole for storage.Glutathione S-transferases(GSTs)are considered to be responsible for the transport of anthocyanins into the vacuole.However,the regulatory mechanisms of GSTs in plants are still unclear.Here,we performed a genome-wide analysis and identified 69 GST genes in apple.The expression of MdGSTF6 was positively correlated with the anthocyanin content(r=0.949)during‘Yanfu 8’fruit development.The overexpression of MdGSTF6 in the Arabidopsis thaliana tt19 mutant resulted in seedlings of 35S::MdGSTF6-GFP/tt19 that could accumulate anthocyanin and rescue its phenotype,suggesting that MdGSTF6 was an anthocyanin transporter.The silencing of MdGSTF6 affected anthocyanin accumulation in apple fruit.Moreover,the knockdown of MdGSTF6 by RNA interference in cultured‘Gala’seedlings inhibited anthocyanin accumulation.The interaction experiments showed that MdMYB1 could bind directly to the MdGSTF6 promoter to transcriptionally activate its expression.Collectively,our results demonstrate that MdGSTF6 encodes an important GST transporter of anthocyanins in apple fruit and provide evidence for the associated regulatory mechanisms.Therefore,MdMYB1 can not only regulate anthocyanin synthesis,but also control the transport of anthocyanin in apples.This information may be useful for further clarifying the regulation of anthocyanin transport in apple. | Shenghui Jiang Min Chen Naibo He Xiaoliu Chen Nan Wang Qingguo Sun Tianliang Zhang Haifeng Xu Hongcheng Fang Yicheng Wang Zongying Zhang Shujing Wu Xuesen Chen | 2019 | Horticulture Research2019，6，1： | 16 |
| 11 | Suppression of Fusarium Wilt of Banana with Application of Bio-Organic Fertilizers显示文摘Fusarium wilt is one of the most serious diseases of banana plants caused by soil-borne pathogen Fusarium oxysporum f.sp. cubense(FOC). In this study a pot experiment was conducted to evaluate the effects of different bio-organic fertilizers(BIOs) on Fusarium wilt of banana, including the investigations of disease incidence, chitinase and β-1,3-glucanase activities of banana plants, and FOC populations as well as soil rhizosphere microbial community. Five fertilization treatments were considered, including chemical fertilizer containing the same N, P and K concentrations as the BIO(control), and matured compost mixed with antagonists Paenibacillus polymyxa SQR-21 and Trichoderma harzianum T37(BIO1), Bacillus amyloliquefaciens N6(BIO2), Bacillus subtilis N11(BIO3), and the combination of N6 and N11(BIO4). The results indicated that the application of BIOs significantly decreased the incidence rate of Fusarium wilt by up to 80% compared with the control. BIOs also significantly promoted plant growth, and increased chitinase andβ-1,3-glucanase activities by 55%–65% and 17.3%–120.1%, respectively, in the banana roots. The population of FOC in the rhizosphere soil was decreased significantly to about 104 colony forming units g-1with treatment of BIOs. Serial dilution plating and denaturing gradient gel electrophoresis analysis revealed that the application of BIOs increased the densities of bacteria and actinomycetes but decreased the number of fungi in the rhizosphere soil. In general, the application of BIOs revealed a great potential for the control of Fusarium wilt disease of banana plants. | ZHANG Nan HE Xin ZHANG Juan W.RAZA YANG Xing-Ming RUAN Yun-Ze SHEN Qi-Rong HUANG Qi-Wei | 2014 | Pedosphere2014，24，5： | 15 |
| 12 | Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation显示文摘 | Li YANG Li-ping SHI Hai-jun CHEN Xian-kun TONG Gui-feng WANG Yang-ming ZHANG Wen-long WANG Chun-lan FENG Pei-lan HE Feng-hua ZHU You-hua HAO Bao-ju WANG Dong-liang YANG Wei TANG Fa-jun NAN Jian-ping ZUO | 2014 | Acta Pharmacologica Sinica2014，35，3： | 14 |
| 13 | Evaluation of vehicle-track-bridge interacted system for the continuous CRTS-II non-ballast track slab显示文摘Considering the CRTS-II track slab,which is commonly used in the Chinese high-speed railway system,a vehicle-track-bridge dynamic analysis method is proposed in which the vehicle subsystem equations are established by the rigid body dynamics method,the track subsystem and the bridge subsystem equations are established by the FEM,the wheel-rail contact relation is defined by the corresponding assumption in vertical direction and the Kalker linear creep theory in lateral direction.The in-span spring element is derived to model the track-bridge interaction;the equal-band-width storage is adopted to fit the track structure with multilayer uniform section beam;and the dynamic equilibrium equations are solved by the inter-history iteration method.As a case study,the response of a CRH2 high-speed train transverses a simply-supported bridge with successive 31.5m double bound pre-stress beams is simulated.The result shows that using the vehicle-track-bridge interaction model instead of the vehicle-bridge interaction model helps predict the rotation angle at beam ends and choose an economic beam vertical stiffness. | ZHANG Nan ZHOU Shuang XIA He SUN Lu | 2014 | Science China(Technological Sciences)2014，57，10： | 14 |
| 14 | A novel CFTR mutation found in a Chinese patient with cystic fibrosis显示文摘Background Cystic fibrosis (CF) is rare in Chinese. We investigated the mutations in the gene of cystic fibrosis transmembrane conductance regulator (CFTR) in a Chinese CF patient and reviewed the clinical features, gene mutations in Chinese CF cases. Methods Blood samples were collected from a previously reported CF girl and her parents. The 24 coding exons of CFTR of the proband were amplified and sequenced. Results A Chinese girl of 16 years old was diagnosed as CF at the age of 14. She had recurrent productive cough with bronchiectasis in bilateral upper lobes, parasinusitis and otitis media, but without pancreatic involvement. Her sweat chloride was (108.9 ±3.3) mmol/L. A heterozygous novel missense mutation of 699 C→ A which results in the amino acid change of N189K was identified in exon 5. In addition, a heterozygous 3821-3823 delT mutation in exon 19 was found in CFTR. The mutation 699C→A was inherited from her father, and the 3821-3823delT mutation was from her mother. Twenty patients with CF in Chinese reported from 1974 to 2004 were also reviewed. DelF508 mutation was not found in the nine cases whose CFTR mutations were analyzed. Conclusions The CF proband carries two heterozygous mutations (699C→A and 3821-3823delT) in CFTR. 699C→A mutation is a novel mutation which is not reported previously. Review of reported Chinese cases suggests that the genotype of Chinese CF may be different from those of white cases. More studies are needed to understand the spectra of CFTR and clinical CF features in Chinese. | LI Nan PEI Pei BU Ding-fang HE Bing WANG Guang-fa | 2006 | Chinese Medical Journal2006，，2： | 14 |
| 15 | A Train-Bridge Dynamic Interaction Analysis Method and Its Experimental Validation显示文摘 | Nan Zhang Yuan Tian He Xia | 2016 | Engineering2016，2，4： | 14 |
| 16 | Chemical fertilizers could be completely replaced by manure to maintain high maize yield and soil organic carbon(SOC)when SOC reaches a threshold in the Northeast China Plain显示文摘The combined use of chemical and organic fertilizers is considered a good method to sustain high crop yield and enhance soil organic carbon(SOC),but it is still unclear when and to what extent chemical fertilizers could be replaced by organic fertilizers.We selected a long-term soil fertility experiment in Gongzhuling,Northeast China Plain to examine the temporal dynamics of crop yield and SOC in response to chemical nitrogen,phosphorus,and potassium(NPK) fertilizers and manure,applied both individually and in combination,over the course of three decades(1980-2010).We aimed to test 1) which fertilizer application is the best for increasing both maize yield and SOC in this region,and 2) whether chemical fertilizers can be replaced by manure to maintain high maize yield and enhance SOC,and if so,when this replacement should be implemented.We observed that NPK fertilizers induced a considerable increase in maize yield in the first 12 years after the initiation of the experiment,but manure addition did not.In the following years,the addition of both NPK fertilizers and manure led to an increase in maize yield.SOC increased considerably in treatments with manure but remained the same or even declined with NPK treatments.The increase in maize yield induced by NPK fertilizers alone declined greatly with increasing SOC,whereas the combination of NPK and manure resulted in high maize yield and a remarkable improvement in SOC stock.Based on these results we suggested that NPK fertilizers could be at least partially replaced by manure to sustain high maize yield after SOC stock has reached 41.96 Mg C ha^(-1) in the Northeast China Plain and highly recommend the combined application of chemical fertilizers and manure(i.e.,60 Mg ha^(-1)). | LI Hui FENG Wen-ting HE Xin-hua ZHU Ping GAO Hong-jun SUN Nan XU Ming-gang | 2017 | Journal of Integrative Agriculture2017，16，4： | 13 |
| 17 | Risk Factors for Lung Cancer in Non-smokers in Xuanwei County of China显示文摘Tobacco smoking and some types of occupational exposures have consistently been considered as important etiologic factors of lung cancer in industrial countrie.At the First World Conference of Lung Cancer(Wyndwer,1983),it was stressed that more attention should be paid to finding out the causes of lung cancer in non-smokers. In Xuanwei County,Yunnan Province,annual lung cancer death rate was 27.7per 100,000 in males,among China's highest,and 25.3per 100,000 in females,the China's highest.The remale's lung cancer death rate in Xuanwei County was even much higher than that of the same period in USA white women(ECACM,1979;Mulvihill,1976),Marked district variation in cancer mortality exists within xuanwei County.The county can be ivided into high-,medium-and low-mortality areas.Over90% of the population are farmers.The local residents traditionally burned three major kinds of fuels:“smoky” coal,“smokeless”coal and “wood”,for heating and cooking.The three lung cancer high mortality areas,including “Chengguan”,“Rongcheng”and “Laibin”communes,mainly burned the “smoky”!coal from Laibin smoky-coal mine.The fuel was burned in a shallow,unventiated fire pit in the floor of the dwelling.Fuel burning in shallow unventialated pits has resulted in high indoor air pollution levels.The concentrations of airborne particles(pm10) inside houses during smoky coal and wood combustion were very high.Indoor concentration of suspended particulates and dichloromethane extractable organics were 244.4mg/m^3 and 17.6mg/m^3 in burning of “smoky”coal;22.2mg/m^3,12.3mg/m^3 for burning wood;and 1.8mg/m^3,0.5mg/m^3 for burning of smokeless coals.Levels of individual polycyclic aromatic hydrocarbons.including benzo(a)pyrene,were generally highest during burning of smoky coal,intermediate in burning wood,and least in smokeless coal.Women did most household chores.which include starting fire and cooking.Less than 0.2% of females smoked tobacco.The population-based casecontrol study presented here is to evaluate the influence of factors on the occurrence of lung cancer in non-smoking women in Xuanwei County and to supplement the etiologic factors of lung cancer in Xuanwei County. | LAN QING, CHEN WEI, CHEN HONG, AND HE XING-ZHOUInstitute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine 29 Nan Wei Road, Beijing 100050, China | 1993 | Biomedical and Environmental Sciences1993，6，2： | 13 |
| 18 | Mushroom Poisoning Outbreaks-China,2020显示文摘What is already known about this topic?Acute liver failure,rhabdomyolysis,acute renal failure,and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese population.The most notorious lethal mushrooms are the species from genera Amanita,Lepiota,and Galerina that cause acute liver failure,and Russula subnigricans that leads to rhabdomyolysis.What is added by this report?In 2020,the total number of investigations reached 676,involving an estimated 102 species of poisonous mushrooms,24 of which were newly recorded in China.Gyromitra venenata was newly discovered in incidents in Yunnan and Guizhou provinces and were the first reported poisonings due to gyromitrins in China since 2000.The rare poisoning Shiitake mushroom dermatitis was recorded in China.Hemolysis poisoning caused by Paxillus involutus was recorded for the second time since the beginning of the new century,resulting in one death in Inner Mongolia Autonomous Region.What are the implications for public health practice?Promoting knowledge about safe consumption of mushrooms is essential to reduce mushroom poisonings.It is not wise to collect and eat wild mushrooms.For southwestern provinces such as Yunnan,especially,caution must be exercised with unfamiliar mushroom species. | Haijiao Li Hongshun Zhang Yizhe Zhang Jing Zhou Yu Yin Qian He Shaofeng Jiang Peibin Ma Yutao Zhang Ke Wen Yuan Yuan Nan Lang Bowen Cheng Junjia Lu Chengye Sun | 2021 | China CDC weekly2021，3，3： | 13 |
| 19 | A population-based survey of gastroesophageal reflux disease in a region with high prevalence of esophageal cancer in China显示文摘Background: The exact relationship between gastroesophageal reflux disease (GERD) and esophageal squamous cell cancer (ESCC) is far from clarification. The aim of this study was to investigate the epidemiology of GERD in a region with high prevalence of ESCC in China. Methods: A population-based, cross-sectional study was conducted in a high ESCC prevalent area, Anyang, Henan, China. All subjects fulfilled questionnaires and underwent gastroendoscopy with routine esophageal biopsy. The subjects were divided into GERD subtypes (reflux esophagitis [RE] and non-erosive reflux disease [NERD]) and controls. Odds ratios (ORs) and 95% confidence intervals (Cis) were calculated to examine risk factors for RE and NERD. Results: A total of 2844 subjects were finally enrolled. The prevalence of GERD (RE + NERD) was 17.3%. Among them, 271 (9.53%) adults were diagnosed with RE. The prevalence of RE increased with age (7.09% in 45-50 years, 8.00% in 51-60 years, and 9.53% in 61-69 years,x^2 = 62.216, P < 0.001). Sixty-seven (2.36%) subjects were diagnosed with the silent RE. A total of 221 (7.77%) subjects were diagnosed with NERD. Frequent liquid food consumption (OR [95% CI]: 1.502 [1.076-2.095]) was independent risk factor for RE as well as age, male gender, high body mass index (BMI), ever smoking. Age was independent risk factor for NERD. For silent RE, age, male gender, and frequent liquid food consumption were risk factors. Conclusions: In the population with high prevalence of ESCC, a high prevalence of GERD and inverted proportion of RE/NERD were presented. Age was an independent risk factor for GERD. The male gender, high BMI, smoking, and frequent liquid food consumption may be risk factors for RE but not for NERD. | Kun Wang Li Zhang Zhong-Hu He Zuo-Jing Liu Lu Zhang Nan Hu Zhu Jin Yang Ke Li-Ping Duan | 2019 | Chinese Medical Journal2019，，13： | 13 |
| 20 | 3D N,O-Codoped Egg-Box-Like Carbons with Tuned Channels for High Areal Capacitance Supercapacitors显示文摘Functional carbonaceous materials for supercapacitors(SCs)without using acid for post-treatment remain a substantial challenge.In this paper,we present a less harmful strategy for preparing three-dimensional(3D)N,O-codoped egg-box-like carbons(EBCs).The as-prepared EBCs with opened pores provide plentiful channels for ion fast transport,ensure the e ective contact of EBCs electrodes and electrolytes,and enhance the electron conduction.The nitrogen and oxygen atoms doped in EBCs improve the surface wettability of EBC electrodes and provide the pseudocapacitance.Consequently,the EBCs display a prominent areal capacitance of 39.8μF cm-2(340 F g-1)at 0.106 m A cm-2 in 6 M KOH electrolyte.The EBC-based symmetric SC manifests a high areal capacitance to 27.6μF cm-2(236 F g-1)at 0.1075 m A cm-2,a good rate capability of 18.8μF cm-2(160 F g-1)at 215 m A cm-2 and a long-term cycle stability with only 1.9%decay after 50,000 cycles in aqueous electrolyte.Impressively,even in all-solid-state SC,EBC electrode shows a high areal capacitance of 25.0μF cm-2(214 F g-1)and energy density of 0.0233 m Wh cm-2.This work provides an acid-free process to prepare electrode materials from industrial by-products for advanced energy storage devices. | Feng Wei Xiaojun He Lianbo Ma Hanfang Zhang Nan Xiao Jieshan Qiu | 2020 | Nano-Micro Letters2020，12，7： | 13 |
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