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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | 16年随访的前瞻性队列中521120名个体的膳食脂肪摄入与总死亡率和特定原因死亡率的关系显示文摘饱和脂肪摄入与心血管健康相关性的证据存在争议。不饱和脂肪和总死亡率及心血管病死亡率的相关性存在不一致性,并且关于非心血管病死亡率的数据较少。该文旨在评估膳食脂肪与总死亡率和特定原因死亡率的关系。方法和结果:研究者分析了来自随访16年的美国国立卫生研究院一美国退休人员协会膳食与健康研究年龄50~71岁的参与者521 120人的数据。通过食品频率问卷评估饱和脂肪酸(saturatedfatty acid,SFA )、反式脂肪酸(trans-fatty acid,TFA)、单不饱和脂肪酸(monounsaturated fatty acid,MUFA)与多不饱和脂肪酸(polyunsaturated fattyacid,PUFA)的摄入量。 | 陈嘉睿(译) 练桂丽(审校) Zhuang P Zhang Y He W Chen X Chen J He L Mao L Wu F Jiao J | 2019 | 中华高血压杂志2019，27，4： | 7 |
| 3 | Passive and hybrid control systems for seismic protection of a benchmark cable-stayed bridge 显示文摘 | He W L Aqrawal A K | 2007 | Structural Control and Health Monitoring2007，14，1： | 1 |
| 4 | A probabilistic reasoning-based decision support system for selecting remediation technologies for petroleum-contaminated sites 显示文摘 | HE L CHAN C W HUANG G H ZENG G M | 2006 | Expert Systems with Applications2006，30，4： | 1 |
| 5 | Experimental observations on the mechanical properties of nanoscale ceramic/Teflon multilaters显示文摘 | HE J L WANG L D LI W Z | 1998 | Mater Chem Phys1998，54，13： | 1 |
| 6 | Binding of puerarin to human serum albumin:a spectroscopic analysis and molecular docking显示文摘 | HE Y WANG Y W TANG L F LIU H CHEN W ZHENG Z L ZOU G L | 2008 | J Fluoresc2008，18，2： | 1 |
| 7 | Modeling and simulation for hybrid electric vehicles-part II: simulation显示文摘 | HE X L HODGSON J W | 2002 | IEEE Transaction on Intelligent Transportation Systems2002，3，4： | 1 |
| 8 | Synthesis of α-Bromo-4-Substituted-Phenone显示文摘 | HU A X HE L M SHI W G | 2004 | Fine Chemicals2004，21，： | 1 |
| 9 | Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy显示文摘 | Hinton DR Spee C He S Weitz S Usinger W LaBree L | 2004 | Diabetes Care2004，27，3： | 1 |
| 10 | Enhanced therapeutic efficacy of tumor RNA- pulsed dendritic cells after genetic modification with lymphotactin显示文摘 | Zhang W He L Yuan Z | 1999 | Hum Gene Ther1999，10，7： | 1 |
| 11 | TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance显示文摘 | HE W LIU Q WANG L | 2007 | Mol Immunol2007，44，11： | 1 |
| 12 | Ti-based Nano-structure-dendrite Composite with Enhanced Plasticity显示文摘 | G He J Eckert W Loeser L Novel | 2003 | Nature Mater2003，2，1： | 1 |
| 13 | Nanotechnology显示文摘 | Zhang M He X W Chen L X ZHANG Y K | 2011 | 22 : 12011，22，： | 1 |
| 14 | Hepatitis B virus with a pro- posed genotype I was found in sichuan province,China显示文摘 | TONG W B HE J L SUN L | 2012 | J Med Viro12012，84，6： | 1 |
| 15 | 3D numerical simulation on shell-and-tube heat exchangers with middle-overlapped helical baffles and continuous baffles-Part II : Simulation results of periodic model and comparison between continuous and noncontinuous helical baffles显示文摘 | Zhang J F He Y L Tao W Q | 2009 | International Journal of Heat and Mass Transfer2009，52，2324： | 1 |
| 16 | Experimental study on the performance of CO2 residential air-conditioning system with anInternal heat exchanger显示文摘 | Tao Y B He Y L Tao W Q Wu Z G | | 0，，01： | 1 |
| 17 | 查看详情显示文摘 | Zhang J P Yang H P Han K L Deng W Q He G Z Lou N Q | | 0，，： | 1 |
| 18 | Emergence, circulation, and spatiotemporal phylogenetie analysis of eoxsaekievirus a6 - and coxsackievirus al0 - associated hand, foot, and mouth disease infections from 2008 to 2012 in shenzhen, china显示文摘 | He Y Q Chen L Xu W B | 2013 | J Clin Microbiol2013，51，11： | 1 |
| 19 | Effects of novolac resin modification on mechanical properties of carbon fiber/epoxy composites 显示文摘 | He H W Li K X Wang J L | 2011 | Polym Compos2011，32，2： | 1 |
| 20 | Quantum-dot-conjugated graphene as a probe for simultaneous cancer-targeted fluores- cent imaging,tracking,and monitoring drug delivery显示文摘 | Chen M L He Y J Chen X W et al | 2013 | Biocon- jugate Chemistry2013，24，3： | 1 |
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