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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | 跟骨关节内移位骨折的功能疗效和患者满意度——切开复位、经皮手术和非手术治疗对比研究显示文摘对于跟骨关节内移位骨折,约60%的工薪阶层患者会选择切开复位内固定术(openreductionandinternalfixation,ORIF)治疗,术后恢复工作通常需要5~10个月,相当一部分患者1年内无法恢复工作;而对于保守治疗患者,骨折症状通常会持续1~2年,高达16%的患者需行关节内固定手术。本研究的主要目的是比较3种跟骨关节内移位骨折治疗方案——ORIF、经皮手术和非手术治疗的疗效差异。 | De Boer AS Van Lieshout EM Den Hartog D 叶翔凌 夏远军 | 2016 | 中国骨科临床与基础研究杂志2016，8，6： | 2 |
| 3 | Annual cycles of water vapour and carbon dioxide fluxes in and above a boreal aspen forest显示文摘 | BLACK T A HARTOG G D NEUMANN H H | 1996 | Global Change Biology1996，2，： | 1 |
| 4 | Ondinea,a new genus of Nymphaeaceae显示文摘 | Hartog C D | 1970 | Blumea1970，18，： | 1 |
| 5 | When does Transformational Leadership Enhance Employee Proactive Behavior, the Role of Autonomy and Role Breadth Self-efficacy 显示文摘 | DEN HARTOG D N BELSCHAK F D | 2012 | Journal of Applied Psychology2012，97，1： | 1 |
| 6 | Primary shoulder arthmplasty versus conservative treatment for comminuted proximal humeral fractures : a systematic literature review 显示文摘 | den Hartog D de Haan J Sehep NW | 2010 | Open Orthop J2010，4，： | 1 |
| 7 | Open surgical procedures for incisional hernias显示文摘 | den Hartog D Dur AH Tuinebreijer WE | 2008 | Cochrane Database Syst Rev2008，16，3： | 1 |
| 8 | Primary shoulder arthroplasty versus conservative treatment for comminuted proximal humeral fractures: a systematic literature review显示文摘 | Den Hartog D De Haan J Schep NW | 2010 | Open Orthop J2010，4，： | 1 |
| 9 | Ethical and Despotic Leadership, Relationships with Leader's Social Re- sponsibility, Top Management Team Effectiveness and Subordi-nates' Optimism: A Multi-method Study 显示文摘 | De Hoogh A Den Hartog D | 2008 | Leadership Quarterly2008，19，3： | 1 |
| 10 | Linking the Big Five-Factors of personality to charismatic and transactional leadership; perceived dynamic work environment as a moderator显示文摘 | De Hoogh A H B Den Hartog D N Koopman P L | 2005 | Journal of Organizational Behavior2005，26，7： | 1 |
| 11 | Palliative treatment in patients with unreseetable hilar eholangiocarcinoma: results of endoscopic drainage in patients with type Ⅲ and Ⅳ hilar cholangio - carcinoma显示文摘 | Gerhards MF Den Hartog D Rauws EA | 2001 | European Journal of Surgery2001，167，4： | 1 |
| 12 | Diagnosis of arterial disease of the lower extremities with duplex uhrasonography 显示文摘 | Koelemay MJ den Hartog D Prins MH | 1996 | Br J Surg1996，83，： | 1 |
| 13 | Consequences of Positive and Negative Feedback:The Impact on Emotions and Ex-tral-role Behaviors显示文摘 | Belschak F D Den Hartog D N | | 0，，： | 1 |
| 14 | Primary hemiarthroplasty versus conservative treatment for comminuted fractures of the proximal humerus in the elderly(ProCon):a multicenter randomized controlled trial显示文摘 | Den Hartog D Van Lieshout EM Tuinebreijer WE | | 0，，： | 1 |
| 15 | Culture Specificand Crossculturally Generalizable Implicit leadership Theories are Attributes of Charismatic or Transformational Leadership Universally Endorsed? 显示文摘 | Den Hartog D N House R J Hanges P J | 1999 | The Leadership Quarter1y1999，10，2： | 1 |
| 16 | Transmission line vibration due to sleet显示文摘 | Hartog J P D | | 0，，04： | 1 |
| 17 | Air pollution from traffic in city districts near major motorways显示文摘 | ROORDA-KNAPE M C JANSSEN N A H HARTOG J J D | 1998 | Atmos Environ1998，32，11： | 1 |
| 18 | Palliative treatment in patients with unresectable hilar cholangiocarcinoma: results of endoscopic drainage in patients with type Ⅲ and Ⅳ hilar cholangiocarcinoma显示文摘 | Gerhards M-F den Hartog D Rauws EA | 2001 | Eur J Surg2001，167，4： | 1 |
| 19 | Improved Oxygenation by Nitric Oxide Is Enhanced by Prior Lung Reaeration with Surfactant, Rather than Positive End-expiratory Pressure,in Lung-lavaged Rabbits显示文摘 | Gommers D Hartog A van't Veen A | 1997 | Crit Care Med1997，25，11： | 1 |
| 20 | APC in flexible gastrointestinal endoscopy: pilot experiences显示文摘 | Wahab P J Mulder C J J den Hartog G D | 1997 | Endoscopy1997，29，： | 1 |
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