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| 1 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 2 | Anti-CD16/CD30 bispecific antibody treatment for Hodgkin's disease: role of infusion schedule and costimulation with cytokines 显示文摘 | Hartmann F Renner C Jung W ET aI | 2001 | Clinical Cancer Research2001，7，7： | 1 |
| 3 | Identification d fluoroquinolone antibiotics as the main source of human genotoxieity in native hospital waatewater显示文摘 | HARTMANN A ALDER A C KOLLER T | 1998 | Environmental Toxicololgy and Chemistry1998，17，： | 1 |
| 4 | Recommendations for conducting the in vivo alkaline Comet assay显示文摘 | A Hartmann E Agurll C Beevers | 2003 | Mutagenesis2003，18，1： | 1 |
| 5 | Qualitative study of collagenous and noncollagenous glycoproteins of the human healthy keratinized mucosa surrounding implants 显示文摘 | Chavrier C Couble ML Hartmann DJ | 1994 | Clin Oral Implants Res1994，5，3： | 1 |
| 6 | Interleukin-1 alpha as a potent inhibitor of gonadotropin action in porcine Leydig cells: sites of action显示文摘 | Mauduit C Chauvin MA Hartmann DJ | 1992 | Biol Reprod1992，46，51： | 1 |
| 7 | Improvement of health-related quality of life in breast cancer patients by inpatient rehabilitation显示文摘 | Hartmann U Ring C Reuss-Borst MA | 2004 | Med Klin ( Munieh)2004，99，： | 1 |
| 8 | Electrophoretic and immu- noehemical study of collagens from sepia officinalis Cartilage 显示文摘 | Rigo C Hartmann D J Bairati A | 2002 | Biochimica et Biophysi Acta2002，1572，： | 1 |
| 9 | Relation between lipoprotein(a) and fibrinogen and serial intravascular ultrasound plaque progression in left main coronary arteries 显示文摘 | Hartmann M von Birgelen C Mintz G S | 2006 | JAm Coil Cardiol2006，48，3： | 1 |
| 10 | KRAS status and efficacy of first-line treatment of patients with metastatic colorectal cancer (mCRC) with FOLFOX with or without cetuximab:The OPUS experience显示文摘 | Bokemeyer C Bondarenko I Hartmann JT | 2008 | J Clin Oncol2008，26，5： | 1 |
| 11 | Intraocular availability of topically applied mycophenolate mofetil in rabbits 显示文摘 | Knapp S Bertelmann E Hartmann C | 2003 | J Ocul Pharmcol Ther2003，19，2： | 1 |
| 12 | 显示文摘 | Wachtlin J Schrunder S Pham D T Hoffmann F Hartmann C | 1998 | Ophthalmologe1998，95，： | 1 |
| 13 | Gastroin-testinal nematode infection interferes with experimentalallergic airway inflammation but not atopic dermatitis显示文摘 | Hartmann S Schnoeller C Dahten A | 2009 | Clin Exp Allergy2009，39，15： | 1 |
| 14 | NF2 mutations in secretory and other rare variants of meningiomas显示文摘 | Hartmann C Sieberns J Gehlhaar C | 2006 | Brain Pathol2006，16，： | 1 |
| 15 | Using climate forecasts for water management:Arizona and the 1997-1998 El Ni(n)o显示文摘 | Pagano T C Hartmann H C Sorooshian S | | 0，，5： | 1 |
| 16 | A rechargeable room-temperature sodium superoxide (NaOz) battery显示文摘 | Hartmann P Bender C L Vracar M | 2013 | Nature Materials2013，12，3： | 1 |
| 17 | Z-path SAW RFID tag显示文摘 | Harma S Plessky V P Hartmann C S | 2008 | IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control2008，55，1： | 1 |
| 18 | Determinants of neurological outcome after surgery for brain arteriovenous malformation显示文摘 | Hartmann A Stapf C Hofmeister C | 2003 | Stroke2003，31，10： | 1 |
| 19 | A field technique for evaluating physical condition of deer显示文摘 | Kistner T P Trainer C E Hartmann N A | 1980 | Wildl Soc Bull1980，8，1： | 1 |
| 20 | Trace determinationof fluoroquinolone antibacterial agents in urban wastewater by solid-phase extraction and liquid chromatography with fluorescence detection显示文摘 | Golet E M Alder A C Hartmann A | 2001 | Anal Chem2001，73，： | 1 |
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