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| 1 | 器官移植受体发生EBV阳性的皮肤黏膜溃疡:一种局限性惰性移植后淋巴组织增殖性疾病显示文摘Epstein-Barr 病毒( EBV )阳性的皮肤黏膜溃疡( EBV MCU)是在老人或医源性免疫受损患者中发生的一种B细胞淋巴组织增殖性疾病,尚未见发生于实体器官移植受者的报道。作者在70例EBV阳性移植后淋巴组织增殖性疾病( PTLD)患者中发现7例EBV阳性MCU。包括5例肾脏、1例心脏和1例肺脏移植,其中男性5例。患者中位年龄61岁,4例发生于口腔黏膜,3例发生于胃肠道。溃疡病变发生前患者接受免疫抑制治疗0.6-13年。溃疡由炎症细胞和多形性或单形性大细胞增生,破坏皮肤黏膜而形成。5例中可见Reed-Sternberg样细胞。所有病例CD20、CD30阳性,原位杂交EBER结果阳性。3例近期患者被诊断为EBV阳性MCU,4例患者前期被诊断为单形性大细胞PTLD(n=3)和多形性 PTLD ( n =1)。所有患者血液 EBV DNA 均阴性(〈1000拷贝数/ml),而在诊断或随访的44例移植患者中有35例发生系统性 PTLD ( P 〈0.001)。所有 EBV 阳性MCU患者通过减少免疫抑制剂用量(7/7),调整免疫抑制剂用量(2/7),和联用利妥昔单抗(3/7)等使皮损得到治愈。目前5例存活:其中4例身体健康,1例在等待肾移植手术;另2例分别在EBV阳性MCU治愈后的3年和5年死亡。未发现EBV阳性MCU复发或其他PTLD。 | Hart M Thakral B Yohe S 胡舜摘 余英豪 | 2014 | 临床与实验病理学杂志2014，30，12： | 5 |
| 2 | Acquired segmental colonic hypoganglionosis in an adult Caucasian male:A case report显示文摘BACKGROUND Hypoganglionosis is a rare condition that most often presents with abnormal gastrointestinal transit and usually arises in early childhood or adolescence. Two types have been described(Type I and Type II). The adult-onset form(acquired hypoganglionosis) is extremely uncommon and is thought to arise due to cellular remodelling as a result of chronic inflammation. It differs from Hirschprung's disease in that there is a reduction in ganglion cells in the colonic neural plexuses as opposed to being completely absent.CASE SUMMARY A 31 year-old male presented to hospital with recurrent abdominal pain and vomiting over thirteen months. Abdominal computed tomography scans demonstrated thickening and stranding affecting the transverse, descending and sigmoid colon. Endoscopic appearances were non-specific but confirmed a mixed picture of mucosal inflammation and necrosis in various stages of healing.Numerous investigations were performed to elucidate an underlying aetiology but neither an infective nor ischaemic cause could be proven. Biopsy features were not typical of inflammatory bowel disease. Due to persistence of his symptoms and failure of medical management, a segmental colectomy was performed. Histological examination of the specimen revealed an unexpected finding of segmental hypoganglionosis. Complete surgical excision of the diseased segment of colon was curative and since his operation the patient has had no recurrence of symptoms requiring hospitalisation.CONCLUSION Our case serves to raise awareness of acquired hypoganglionosis as a rare condition that can result from chronic colitis. | Allan MF Kwok Andrew B Still Kimberly Hart | 2019 | World Journal of Gastrointestinal Surgery2019，11，2： | 3 |
| 3 | Voltammetric behavior of ascorbic acid at a graphite-epoxy composite electrode chemically modified with cobalt phthalocyanine and its amperometric determination in multivitamin preparations显示文摘 | Wring S A Hart J P Birch B J | 1990 | Anal Chim Acta1990，229，： | 2 |
| 4 | Indirect enzyme-linked immunosorbent assay for the mycotoxin zearalenone显示文摘 | Liu M T Ram B P Hart L P and Pestka J J | 1985 | Appl Environ Microbiol1985，50，2： | 1 |
| 5 | 13C andl5N natural abundance of the soil microbial biomass显示文摘 | Dijkstra P Ishizu A Doucett R Hart S C Schwartz E Menyailo O V Hungate B A | 2006 | Soil Biology & Biochemistry2006，38，： | 1 |
| 6 | Synthesis ofdimethylcarbonate by vapor phase oxidative carbonylation of methanol over Cu-based catalysts显示文摘 | Hart M S Lee B G Ahn B S | 2001 | Journal of Molecular Catalysis2001，170，1： | 1 |
| 7 | Apramycin-resistant Escheriehia coli isolated from pigs and a stockman显示文摘 | Hunter J E B Bennett M Hart C A | 1994 | Epidemiol infect1994，112，： | 1 |
| 8 | Vibration analysis of circtdar Mindlin plates using the differential quadrature method显示文摘 | Liew K M Hart J B Xiao Z M | 1997 | Journal of Sound and Vibration1997，205，5： | 1 |
| 9 | External skeletal fixation of canine tibial osteotomies: Compression compared with no compression显示文摘 | Hart M B Wu J J Chao EYS | 1985 | J Bone Joint Surg(Am)1985，67，4： | 1 |
| 10 | Crystal structure of the human TβR2 ectodom-TGF-β3 complex显示文摘 | P John Hart Shas hank deep Alexander B | 2002 | Nat Struct Biol2002，9，3： | 1 |
| 11 | Do Corporate Global Environmental Standards Create or Destroy Market Value? 显示文摘 | Dowell G Hart S L Yeung B | 2000 | Management Science2000，46，8： | 1 |
| 12 | Evalution of the airtraq and macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation 显示文摘 | MAHARAJ C H COSTELLO J F HARTE B H | 2008 | Anaesthesia2008，63，2： | 1 |
| 13 | New natural draft cooling tower of 200 m of height显示文摘 | BUSCH DIETER HARTE REINHARD KR:_TZIG WILFRIED B | 2002 | Engi- neering Structures2002，，24： | 1 |
| 14 | A crop of maize variants 显示文摘 | Huang X H Hart B | 2012 | Nat Genet2012，44，7： | 1 |
| 15 | New natural draft cooling tower of 200m of height 显示文摘 | Busch D Harte R Krtzig Montag W B U | 2002 | Engineering Structures2002，24，12： | 1 |
| 16 | Application of the Australian river bioassessmentsystem ( AUSRIVAS) in the Brantas River, East Java,Indonesia 显示文摘 | Hart B T Davies P E Humphrey C L | | Journal of Environmental Management0，，： | 1 |
| 17 | Evaluation of intubation using the Airtraq or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy-a manikin study显示文摘 | MAHARAJ C H HIGGINS B D HARTE B H | 2006 | Anaesthesia2006，61，5： | 1 |
| 18 | Active packaging of freshchicken breast,with Allyl Isothiocyanate( AITC) incombination with modified atomosphere packaging ( MAP) to control the growth of pathgens 显示文摘 | ShinJ Harte B Ryser E | 2010 | J Food Sci2010，75，2： | 1 |
| 19 | A Theory of Firm Scope 显示文摘 | O Hart B Holmstrom | 2002 | Working Paper2002，，8： | 1 |
| 20 | In vitro models to predict blood-brain barrier permeability显示文摘 | Eddy E P Maleet B E Hart T K | 1997 | Adv Drug Del Rev1997，23，123： | 1 |
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