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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | A comparative study on the starting methods of three phase wound- rotor induction motor-Part I显示文摘 | Hamouda R M Alolah A I Badr M A | 1999 | IEEE Trans on Energy Conversion1999，14，4： | 1 |
| 3 | Klebsiella pneumoniae susceptibility to biocides and its association with cep A,qacΔE and qac E efflux pump genes and antibiotic resistance显示文摘 | Abuzaid A Hamouda A Amyes SG | 2012 | J Hosp Infect2012，8，2： | 1 |
| 4 | Effect of fatty acids,water composition and pH on the wettability alteration of calcite surface显示文摘 | Hamouda A A | 2006 | Joumal of Petroleum Science and Engineering2006，50，： | 1 |
| 5 | Fitting lactation curves of dairy cattle in different types of herds in Tunisia显示文摘 | REKIK B GARE A B HAMOUDA M B | 2003 | Livest Prod Sci2003，83，： | 1 |
| 6 | Modeling of the thermal history of the sand casting process 显示文摘 | Sulaiman S Hamouda A M S | 2001 | Journal of Materials Processing Technology2001，113，： | 1 |
| 7 | A doubleblind randomized trial of wound and intercostal space infiltration with ropivacaine during breast cancer surgery:effects on chronic postoperative pain显示文摘 | Albi-Feldzer A Hamouda S Motamed C | 2013 | Anesthesiology2013，118，2： | 1 |
| 8 | Mesh erosion into the urinary bladder following laparoscopic inguinal hernia repair;is this the tip of the iceberg?显示文摘 | Hamouda A Kennedy J Grant N | 2010 | Hernia2010，14，3： | 1 |
| 9 | Fabrica- tion of fiber reinforced metal matrix composites by squeeze casting technology显示文摘 | VIJAYARAM T R SULAIMAN S HAMOUDA A M S | 2006 | Journal of Materials Processing Technology2006，178，： | 1 |
| 10 | The first carbonate field application of a new organically cross-linked water shut-off polymer system显示文摘 | Hardy B R Botermans H W Hamouda A | 1999 | SPE1999，50，738： | 1 |
| 11 | Vulnerability assessment of water resources systems in the Eastern Nile Basin 显示文摘 | HAMOUDA M A NOUR EL-DIN M M MOURSY F I | 2009 | Water Resources Management2009，23，13： | 1 |
| 12 | Klebsiella pneumoniae susceptibility to biocides and its association with cepA,qacΔE and qacE efflux pump genes and antibiotic resistance显示文摘 | Abuzaid A Hamouda A Amyes S G | 2012 | J Hosp Infect2012，81，2： | 1 |
| 13 | Eleven novelOXA-51-like enzymes from clinical isolates of Acineto-bacter baumannii 显示文摘 | Evans B A Brown S Hamouda A | 2007 | Clin Microbiol Infect2007，13，： | 1 |
| 14 | Fabrieation of fiber reinforced metal matrix composite by squeeze casting technology显示文摘 | VIJAYARAM T R SULAIMAN S HAMOUDA A M S | 2006 | Journal of Materials Processing Technology2006，178，： | 1 |
| 15 | An adap- tive-learning algorithm to solve the inverse kinematics prob- lem of a 6-DOF serial robot manipulator显示文摘 | Hasan A T Hamouda A M S Ismail N | 2006 | Advances inEngineering Software2006，37，7： | 1 |
| 16 | Effect of fatty acids,water composition and pH on the wettability alteration of calcite sur- face显示文摘 | Rezaei Gomari K A Hamouda A A | 2006 | Journal of Petroleum Science and Engineering2006，50，： | 1 |
| 17 | Development of Machine Learning Strategy for Acquiring On--Line Machining Skills During Turning Process显示文摘 | Al Assadi H M A A Wong S V Hamouda A M S | 2004 | Journal of Materials Processing Technology2004，，： | 1 |
| 18 | Cross-layer Antenna Selection and Channel Allocation for MIMO Cognitive Radios显示文摘 | Ghosh A Hamouda W | 2011 | IEEE Transactions on Wireless Communications2011，10，11： | 1 |
| 19 | Klebsiella pneumoniae susceptibility to biocides and its association with eepA, qacAE and qacE efflux pump genes and antibiotic resistance显示文摘 | Abuzaid A Hamouda A Amyes SG | 2012 | J Hosp Infect2012，81，2： | 1 |
| 20 | Crushing response of composite corrugated tubes to quasi-static axial loading显示文摘 | Elgalai A M Mahdi E Hamouda A M S | 2004 | Composite Structures2004，66，14： | 1 |
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