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| 1 | Assessment of metastatic liver disease in patients with primary extrahepatic tumors by contrast-enhanced sonography versus CT and MRI显示文摘瞄准:与已知的额外的肝的原发性瘤对包括 CT, MRI 和临床 / 组织学的数据的联合标准答案在病人在肝转移的察觉用 SonoVue 评估提高对比的 ultrasonography (CEUS ) 。方法:它是一国际多集中学习,并且有 12 个中心和 125 个病人(64 男性, 61 女性,变老 59+/-11 年) 包含,与 102 个病人一起每协议。原发性瘤是在 35% 表面的颜色,在 27% 的胸,在 17% 胰腺并且其它在 21% 。用 SonoVue 的 CEUS 用西门子 Elegra, Philips HDI 5000 和 Acuson 红杉与一种 low-mechanical-index 技术和对比特定的软件被采用;为至少五分钟的连续扫描。结果:有 SonoVue 的 CEUS 显著地增加了检测的焦点的肝损害对 unenhanced sonography 的数字。在 31.4% 病人,更多的损害在对比改进以后被发现。检测的损害的全部的数字与 CEUS (55 ) 是可比较的,三倍阶段的螺线 CT (61 ) 和有一个肝特定的对比代理人(53 ) 的 MRI。变形疾病的察觉的精确性(即至少一变形损害) 比为 unenhanced sonography (81.4%) 为 CEUS (91.2%) 是显著地更高的并且类似于三倍阶段的螺线 CT (89.2%) 的。在其 CEUS 检查否定的 53 个病人,后续考试 3-6 瞬间以后在 50 个病人(94.4%) 证实了变形损害的缺席。结论:CEUS 被证明在在有已知的额外的肝的原发性瘤的病人的肝转移的察觉可靠并且怀疑肝损害。 | Christoph F Dietrich Wolfgang Kratzer Deike Strobel Etienne Danse Robert Fessl Alfred Bunk Udo Vossas Karlheinz Hauenstein Wilhelm Koch Wolfgang Blank Matthijs Oudkerk Dietbert Hahn Christian Greis | 2006 | World Journal of Gastroenterology2006，12，11： | 39 |
| 2 | Intra-habitat heterogeneity of microbial food web structure under the regime of eutrophication and sediment resuspension in the large subtropical shallow Lake Taihu, China显示文摘 | Wu QLL Chen YW Xu KD Liu ZW Hahn MW | 2007 | 中国生物学文摘2007，21，8： | 26 |
| 3 | Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases显示文摘瞄准:为了如果特定的细胞毒素的 T 房间回答能与恶意的肝在病人被导致,估计,肿瘤与无线电频率对待脱离(RFA ) 。方法:有颜色的肝转移的六个病人表面的癌症并且 6 与肝细胞,癌(HCC ) 经历了 RFA。血以前被取样,在 RFA 以后的 4 和 8 wk。测试抗原是活体检视从每个病人获得的自体同源的肝和肿瘤溶解产物。外部 T 房间激活被一个干扰素鲸鱼群妈(IFNgamma ) 估计分泌物试金和流动血细胞计数。T 房间是双 stained 让 CD4/CD8 和 IFNgamma 检测细胞毒素的 T 房间。积极的 IFNgamma 和 IFNgamma 否定 T 房间的比率作为刺激索引(SI ) 被决定。估计细胞溶解的活动, T 房间与人的 CaCo 颜色被共同孵化 cytosolic adenylate 激酶的表面的癌症和 HepG2 HCC 房间和版本被酶试金测量。结果:在 RFA SI 前是 0.021 (+/- 0.006 ) 为 CD4 (+) 并且 0.022 (+/- 0.004 ) 为对非恶意的肝织物的 CD8 (+) T 房间并且 0.018 (+/- 0.005 ) 为 CD4 (+) 并且 0.021 (+/- 0.004 ) 为对自体同源的肿瘤织物的 CD8 (+) 房间。在对肿瘤织物的 RFA SI 以后的四个星期增加了到 0.109 (+/- 0.005 )为 CD4 (+)并且 0.11 (+/- 0.012 )为对 HCC 的 CD8 (+) T 房间,并且到 0.115 (+/- 0.031 )为 CD4 (+)并且 0.15 (+/- 0.02 )为为颜色的 CD8 (+)房间表面的转移( P <
0.0001 )。没有增加的 SI 被观察与非,恶性瘤织物根本预定点。与 2.62 在对各自的癌症房间的 RFA 细胞溶解的的活动前是低的(+/- 0.37 ) 相对的光单位(RLU ) ,而是超过 100 合拢的玫瑰在 RFA 以后的 4 和 8 wk。自发的版本是 2% 最大值在所有实验释放的 <
。结论:病人与主要并且肝的继发性瘤在 RFA 以后与 CD8 (+) T 房间的一项戏剧性地增加的肿瘤 specific 细胞溶解的活动显示出重要肿瘤特定的细胞毒素的 T 房间刺激。 | Johannes Hansler Thaddaus Till Wissniowski Detlef Schuppan Astrid Witte Thomas Bernatik Eckhart Georg Hahn Deike Strobel | 2006 | World Journal of Gastroenterology2006，12，23： | 22 |
| 4 | 抗焦虑药减轻良性阵发性位置性眩晕在管石复位成功后的残余头晕感显示文摘目的:管石复位治疗(CRP)能有效治疗良性阵发性位置性眩晕(BPPV),但许多患者在CRP治疗成功后仍有持续的头晕感。本研究的目的在于评价抗焦虑药物辅助治疗对CRP治疗成功后残余头晕感的疗效。方法:2011-01-2011-03期间73例BPPV患者接受CRP治疗成功,并随机分为药物组和对照组。药物组患者服用低剂量的依替唑仑2周,对照组患者不用药。所有患者在进行主观垂直视觉检查后2周复诊,采用头晕残障量表(DHI)和特定活动平衡信心量表(ABC)评价CRP治疗前后的主观症状变化。结果:2组患者的DHI得分均显著升高,但药物组患者在DHI功能和情绪的分量表分数以及总分上的下降更加显著。结论:本研究表明,抗焦虑药物可能对接受了CRP的BPPV的患者有效。 | HAHN JIN JUNG JA-WON KOO CHONG SUN KIM JI SOO KIM JAE-JIN SONG 张甦琳 冷杨名 孔维佳 | 2013 | 临床耳鼻咽喉头颈外科杂志2013，27，5： | 18 |
| 5 | 全髋关节置换非骨水泥型股骨柄假体髓腔准备的精确性研究显示文摘目的观察非骨水泥型股骨柄假体在股骨近端髓腔中与骨组织的接触情况及使用机器人辅助手术与传统手术结果的比较。方法在10具新鲜成人尸体股骨标本上,分别采用传统手术及机器人辅助手术行股骨近端髓腔准备后植入近端固定的非骨水泥型股骨柄假体(Osteolock)。经一系列处理后,用钻石刀按层厚3mm行硬组织切片,摄片,扫描输入计算机并用特殊软件(IDL)分析假体近端情况。分别测量假体与骨组织间缝隙的宽度以及假体表面缝隙的长度及其所占假体周径的百分比,假体表面与骨直接接触所占的百分比。结果机器人辅助手术组(实验组)平均假体近端表面与骨直接接触率达93.2%(87.6%~99.7%),假体表面与骨组织间存在由手术造成的缝隙率仅为2.9%(0.3%~7.8%),最大缝隙宽度小于1mm;而传统手术组(对照组)骨直接接触率为60.1%(49.2%~70.4%),由手术造成的缝隙率达32.8%(25.1%~39.9%),最大缝隙宽度达3mm。采用机器人辅助手术可使假体表面与骨直接接触率较传统手术增加约33%,手术误差造成的缝隙率仅为传统手术的9%,最大缝隙宽度为传统手术的26%。结论机器人辅助手术可使股骨近端髓腔与非骨水泥型股骨柄的直接接触率明显提高(P<0.001)。 | 吴立东 HJ Hahne J Hassenpflug | 2002 | 中华骨科杂志2002，22，5： | 15 |
| 6 | Relationship between diversion colitis and quality of life in rectal cancer显示文摘AIM:To investigated the incidence of diversion colitis(DC) and impact of DC symptoms on quality of life(QoL) after ileostomy reversal in rectal cancer.METHODS:We performed a prospective study with 30 patients who underwent low anterior resection and the creation of a temporary ileostomy for the rectal cancer between January 2008 and July 2009 at the Department of Surgery,Korea University Anam Hospital.The participants totally underwent two rounds of the examinations.At first examination,endoscopies,tissue biopsies,and questionnaire survey about the symptom were performed 3-4 mo after the ileostomy creations.At second examination,endoscopies,tissue biopsies,and questionnaire survey about the symptom and QoL were performed 5-6 mo after the ileostomy reversals.Clinicopathological data were based on the histopathological reports and clinical records of the patients.RESULTS:At the first examination,all of the patients presented with inflammation,which was mild in 15(50%) patients,moderate in 11(36.7%) and severe in 4(13.3%) by endoscopy and mild in 14(46.7%) and moderate in 16(53.3%) by histology.At the second examination,only 11(36.7%) and 17(56.7%) patients had mild inflammation by endoscopy and histology,respectively.There was no significant difference in DC grade between the endoscopic and the histological findings at first or second examination.The symptoms detected on the first and second questionnaires were mucous discharge in 12(40%) and 5(17%) patients,bloody discharge in 5(17%) and 3(10%) patients,abdominal pain in 4(13%) and 2(7%) patients and tenesmus in 9(30%) and 5(17%) patients,respectively.We found no correlation between the endoscopic or histological findings and the symptoms such as mucous discharge,bleeding,abdominal pain and tenesmus in both time points.Diarrhea was detected in 9 patients at the second examination;this number correlated with the severity of DC(0%,0%,66.7%,33.3% vs 0%,71.4%,23.8%,4.8%,P = 0.001) and the symptom-related QoL(r =-0.791,P < 0.001).CONCLUSION:The severity of DC is related to diarrhea after an ileostomy reversal and may adversely affect QoL. | Dong Nyoung Son Dong Jin Choi Si Uk Woo Jin Kim Bo Ra Keom Chul Hwan Kim Se Jin Baek Seon Hahn Kim | 2013 | World Journal of Gastroenterology2013，19，4： | 14 |
| 7 | Effect of humic substances on the precipitation of calcium phosphate显示文摘For phosphorus (P) recovery from wastewater, the effect of humic substances (HS) on the precipitation of calcium phosphate was studied. Batch experiments of calcium phosphate precipitation were undertaken with synthetic water that contained 20 mg/L phosphate (as P) and 20 mg/L HS (as dissolved organic carbon, DOC) at a constant pH value in the range of 8.0—10.0. The concentration variations of phosphate, calcium (Ca) and HS were measured in the precipitation process; the crystalline state and compositions of the precipitates were analysed by powder X-ray diffraction (XRD) and chemical methods, respectively. It showed that at solution pH 8.0, the precipitation rate and removal efficiency of phosphate were greatly reduced by HS, but at solution pH ≥9.0, the effect of HS was very small. The Ca consumption for the precipitation of phosphate increased when HS was added; HS was also removed from solution with the precipitation of calcium phosphate. At solution pH 8.0 and HS concentrations ≤ 3.5 mg/L, and at pH ≥ 9.0 and HS concentrations ≤ 10 mg/L, the final precipitates were proved to be hydroxyapatite (HAP) by XRD. The increases of solution pH value and initial Ca/P ratio helped reduce the influence of HS on the precipitation of phosphate. | SONG Yong-hui Hermann H. HAHN Erhard HOFFMANN Peter G. WEIDLER | 2006 | Journal of Environmental Sciences2006，18，5： | 11 |
| 8 | Predictive value of multi-detector computed tomography for accurate diagnosis of serous cystadenoma:Radiologic-pathologic correlation显示文摘AIM:To identify multi-detector computed tomography(MDCT) features most predictive of serous cystadenomas(SCAs),correlating with histopathology,and to study the impact of cyst size and MDCT technique on reader performance.METHODS:The MDCT scans of 164 patients with surgically verified pancreatic cystic lesions were reviewed by two readers to study the predictive value of various morphological features for establishing a diagnosis of SCAs.Accuracy in lesion characterization and reader conf idence were correlated with lesion size(≤3cm or≥3cm) and scanning protocols(dedicated vs routine).RESULTS:28/164 cysts(mean size,39 mm;range,8-92mm) were diagnosed as SCA on pathology.The MDCT features predictive of diagnosis of SCA were microcystic appearance(22/28,78.6%),surface lobulations(25/28,89.3%) and central scar(9/28,32.4%).Stepwise logistic regression analysis showed that only microcystic appearance was signifi cant for CT diagnosis of SCA(P=0.0001).The sensitivity,specificity and PPV of central scar and of combined microcystic appearance and lobulations were 32.4%/100%/100% and 68%/100%/100%,respectively.The reader confidence was higher for lesions>3cm(P=0.02) and for MDCT scans performed using thin collimation(1.25-2.5mm) compared to routine 5 mm collimation exams(P>0.05).CONCLUSION:Central scar on MDCT is diagnostic of SCA but is seen in only one third of SCAs.Microcystic morphology is the most significant CT feature in diagnosis of SCA.A combination of microcystic appearance and surface lobulations offers accuracy comparable to central scar with higher sensitivity. | Anjuli A Shah Nisha I Sainani Avinash Kambadakone Ramesh Zarine K Shah Vikram Deshpande Peter F Hahn Dushyant V Sahani | 2009 | World Journal of Gastroenterology2009，15，22： | 11 |
| 9 | Toothpick impaction with sigmoid colon pseudodiverticulum formation successfully treated with colonoscopy显示文摘Foreign bodies in the colon are encountered with increasing frequency, but only sporadic reports concerning their management have appeared in the literature. While most ingested foreign bodies usually pass through the gastrointestinal tract uneventfully, sharp foreign bodies such as toothpicks infrequently cause intestinal perforation and may even result in death. We report our experience with a patient with a sigmoid colon pseudodiverticulum formation, a complication of accidental ingestion of a toothpick that was diagnosed and successfully managed colonoscopically. | Youn Son Chung Yong Woo Chung Sun You Moon Su Mi Yoon Min-Jeong Kim Kyoung Oh Kim Cheol Hee Park Taeho Hahn Kyo-Sang Yoo Sang Hoon Park Jong Hyeok Kim Choong Kee Park | 2008 | World Journal of Gastroenterology2008，14，6： | 10 |
| 10 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 11 | 从讲座制到学系制——兼论德国大学与美国大学的相互影响显示文摘讲座制在德国大学的形成,确立了现代大学的科学研究职能,德国大学因此成为当时世界上最好的大学,并对世界高等教育产生重要影响。美国大学对德国大学讲座制进行继承和发扬,形成了如今的学系制;自20世纪30年代,美国逐渐代替德国成为新的世界高等教育中心,至今对世界各国产生影响。始于20世纪60年代的德国高等教育体制改革,更是效法美国,试图重返世界高等教育领袖地位。借鉴和创新成为德、美两国大学相互影响的基本历史脉络。 | 孔捷 迟芳 Matthias Hahn | 2011 | 江苏高教2011，，2： | 9 |
| 12 | Double-balloon-enteroscopy-based endoscopic retrograde cholangiopancreatography in post-surgical patients显示文摘AIM: To evaluate double balloon enteroscopy (DBE) in post-surgical patients to perform endoscopic retrograde cholangiopancreatography (ERCP) and interventions. METHODS: In 37 post-surgical patients, a stepwise approach was performed to reach normal papilla or enteral anastomoses of the biliary tract/pancreas. When conventional endoscopy failed, DBE-based ERCP was performed and standard parameters for DBE, ERCP and interventions were recorded. RESULTS: Push-enteroscopy (overall, 16 procedures) reached enteral anastomoses only in six out of 37 post-surgical patients (16.2%). DBE achieved a high rate of luminal access to the biliary tract in 23 of the remaining 31 patients (74.1%) and to the pancreatic duct (three patients). Among all DBE-based ERCPs (86 procedures), 21/23 patients (91.3%) were successfully treated. Interventions included ostium incision or papillotomy in 6/23 (26%) and 7/23 patients (30.4%), respectively. Biliary endoprosthesis insertion and regular exchange was achieved in 17/23 (73.9%) and 7/23 patients (30.4%), respectively. Furthermore, bile duct stone extraction as well as ostium and papillary dilation were performed in 5/23 (21.7%) and 3/23 patients (13.0%), respectively. Complications during DBE-based procedures were bleeding (1.1%), perforation (2.3%) and pancreatitis (2.3%), and minor complications occurred in up to 19.1%. CONCLUSION: The appropriate use of DBE yields a high rate of luminal access to papilla or enteral anastomoses in more than two-thirds of post-surgical patients, allowing important successful endoscopic therapeutic interventions. | Martin Raithel Harald Dormann Andreas Naegel Frank Boxberger Eckhart G Hahn Markus F Neurath Juergen Maiss | 2011 | World Journal of Gastroenterology2011，17，18： | 9 |
| 13 | Expression of protein S100A4 is a predictor of recurrence in colorectal cancer显示文摘AIM: To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS: A cohort of archival formalin-fixed paraff inembedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between April 2000 and March 2004 at the Department of Surgery, Korea University Guro Hospital. The expression of protein S100A4 was evaluated according to the proportion of positively stained cancer cells. In each case, three core biopsies with a diameter of 2 mm were punched out and positioned in a recipient paraff in array block. Four-μm sections of these tissue array blocks were used for immunohistochemical analysis of protein S100A4, E-cadherin, and p53. Clinicopathological data were based on the original histopathologic reports and clinical records of patients. RESULTS: In normal colorectal mucosa, protein S100A4 immunoreactivity was clearly absent in both cytoplasm and nucleus. However, positive immunoreactivity of protein S100A4 was detected in 45 (35.4%) of the tumor cases. There was no significant association between positive immunoreactivity of protein S100A4 and clinicopathological parameters such as tumor differentiation or TNM stage, and also no correlation between the reactivity and E-cadherin or p53 expression. However, positive immunoreactivity of protein S100A4 was found to be associated with tumor recurrence (P = 0.004), and was also associated with significantly worse overall survival in the Kaplan-Meyer survival analysis (P = 0.044). After adjustment for tumor differentiation, tumor depth and nodal status, however, it failed to achieve statistical significance (P = 0.067). CONCLUSION: The expression of protein S100A4 is associated with tumor recurrence and poor overall survival in patients with colorectal cancer. | Jung Myun Kwak Hyun Joo Lee Seon Hahn Kim Han Kyeom Kim Young Jae Mok Young Tae Park Jong Sang Choi Hong Young Moon | 2010 | World Journal of Gastroenterology2010，16，31： | 8 |
| 14 | 胫骨高位截骨术治疗膝内侧室骨关节炎的长期随访显示文摘目的 观察胫骨高位截骨术治疗膝内侧室骨关节炎的远期治疗效果。方法 随访了1985~ 1996年 12年间在德国基尔大学骨科医院行胫骨高位截骨术的 194例 (2 15膝 )膝内侧室骨关节炎的患者。结果 有 16 1膝获得随访 ,平均随访时间 7 5年 (1 5~ 12年 )。手术后 2年内的优良率为 97 3% ,5年内的优良率为 93 6 % ,手术后 5年以上的优良率为 78 2 %。 12膝发生手术并发症(5 6 % ) ,主要为感染 (1例深部感染 ,5例浅表感染 ) ,骨不连或骨延迟愈合 5例 ,腓总神经损伤 1例。手术后有 19膝 (11 8% )因治疗效果的下降须再次行全膝关节置换手术。以全膝置换为失败标准的手术成功率分别为 :2年 98 7% ,5年 95 0 %及 10年为 84 1%。结论 胫骨高位截骨术是治疗膝关节内侧骨关节炎的一种有效手段 ,术中下肢力线的适当过度纠正是手术成功的关键 ,远期疗效呈下降趋势 ,有一部分患者须再次行全膝关节置换手术。 | 吴立东 HJ Hahne J Hassenpflug | 2004 | 中华外科杂志2004，42，8： | 8 |
| 15 | Improvement of quantitative testing of liver function in patients with chronic hepatitis C after installment of antiviral therapy显示文摘AIM: To investigate if and to what extent antiviral therapy influenced a broad panel of quantitative testing of liver function (QTLF).METHODS: Fifty patients with chronic hepatitis C were either treated with interferon (n = 8), interferon/ribavirin (n = 19) or peg-interferon/ribavirin (n = 23). Quantitative testing of liver function, including aminopyrine breath test (ABT), galactose elimination capacity (GEC), sorbitol clearance (SCI) and indocyanine green clearance (ICG)was performed before and 3 mo after initiation of antiviral therapy.RESULTS: After 3 mo of antiviral treatment, 36 patients showed normal transaminases and were negative for HCV-RNA, 14 patients did not respond to therapy. ABT and GEC as parameters of microsomal and cytosolic liver function were reduced in all patients before therapy initiation and returned to normal values in the 36 therapy responders after 3 mo. Parameters of liver perfusion (SCI and ICG) were not affected by antiviral therapy. In the 14 non-responders,no changes in QTLF values were observed during the treatment period.CONCLUSION: ICG and SCI remained unaffected in patients with chronic hepatitis C, while ABT and GEC were significantly compromised. ABT and GEC normalized in responders to antiviral therapy. Early determination of ABT and GEC may differentiate responders from non-responders to antivJral treatment in hepatitis C. | Matthias Ocker Marion Ganslmayer Steffen Zopf Susanne Gahr Christopher Janson Eckhart G. Hahn Christoph Herold | 2005 | World Journal of Gastroenterology2005，11，35： | 8 |
| 16 | Closed-loop hydrometallurgical treatment of end-of-life lithium ion batteries: Towards zero-waste process and metal recycling in advanced batteries显示文摘This work presents an enhanced hydrometallurgical process for recycling lithium ion batteries. First, endof-life batteries were processed in a physical pre-treatment plant to obtain a representative electrode material. The resulting leachate was purified forth by iron-precipitation, liquid–liquid extractions, and an innovative Li–Na separation, in order to obtain valuable products. These products include high-grade graphite, cobalt oxide(Co3O4, purity 83%), cobalt oxalate(CoC2O4, purity 96%), nickel oxide(Ni O, purity89%), and lithium carbonate(Li2CO3, purity 99.8%). The recovery rate was quantitative for graphite, between 80% and 85% for cobalt depending on the nature of the recovery method, 90% for nickel, and 72%for lithium. Secondary streams were also valorized to obtain sodium sulfate(Na2SO4, purity 96%), and MnCoFe2O4 magnetic nano-sorbents according to the zero-waste concept. In order to close the loop, recycled Co3O4 and NiO were used as conversion-type anode materials for advanced lithium ion batteries showing promising performances. | Thomas Abo Atia Giuseppe Elia Robert Hahn Pietro Altimari Francesca Pagnanelli | 2019 | Journal of Energy Chemistry2019，28，8： | 8 |
| 17 | Adventitious Roots and Secondary Metabolism显示文摘Plants are a rich source of valuable secondary metabolites and in the recent years plant cell, tissue and organ cultures have been developed as an important alternative sources for the production of these compounds. Adventitious roots have been successfully induced in many plant species and cultured for the production of high value secondary metabolites of pharmaceutical, nutraceutical and industrial importance. Adoption of elicitation methods have shown improved synthesis of secondary metabolites in adventitious root cultures. Development of large-scale culture methods using bioreactors has opened up feasibilities of production of secondary metabolites at the industrial levels. In the present review we summarize the progress made in recent past in the area of adventitious root cultures for the production of secondary metabolites. | Hosakatte Niranjana Murthy Eun Joo Hahn Kee Yoeup Paek | 2008 | 生物工程学报2008，24，5： | 7 |
| 18 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 19 | Laparoscopic complete mesocolic excision: West meets East显示文摘Complete mesocolic excision is a relatively new concept in western literature. It follows the same concept of total mesorectal excision and units' routinely performing complete mesocolic excisions have good pathological results as well as good improvements in overall survival, disease free survival and local recurrence. And yet unlike total mesorectal excision, uptake in the West has been relatively slow with many units sceptical of the true benefits gained by taking up a more technically challenging and potentially more morbid procedure when there is a paucity of literature to support these claims. This article reviews complete mesocolic excision for colon cancer, attempting to identify the risks and benefits of the technique and particularly looking at the reasons why its uptake has not been universal. It also discusses the similarities of a complete mesocolic excision to a colon resection with a D3 lymphadenectomy as well as the role of a laparoscopic approach to this technique. Considering a D3 lymphadenectomy has been the standard of care for stage Ⅱ and Ⅲ colon cancers in many of our Asian neighbours for over 20 years, combining this data with data on complete mesocolic excision may provide enough evidence to support or refute the need for complete mesocolic excisions. Maybe there might be lessons to be learnt from our colleagues in the east. | Carina F K Chow Seon Hahn Kim | 2014 | World Journal of Gastroenterology2014，20，39： | 6 |
| 20 | A tale of worldwide success:Behind the scenes of Carex(Cyperaceae)biogeography and diversification显示文摘The megadiverse genus Carex(c.2000 species,Cyperaceae)has a nearly cosmopolitan distribution,displaying an inverted latitudinal richness gradient with higher species diversity in cold-temperate areas of the Northern Hemisphere.Despite great expansion in our knowledge of the phylogenetic history of the genus and many molecular studies focusing on the biogeography of particular groups during the last few decades,a global analysis of Carex biogeography and diversification is still lacking.For this purpose,we built the hitherto most comprehensive Carex-dated phylogeny based on three markers(ETS-ITS-matK),using a previous phylogenomic Hyb-Seq framework,and a sampling of two-thirds of its species and all recognized sections.Ancestral area reconstaiction,biogeographic stochastic mapping,and diversification rate analyses were conducted to elucidate macroevolutionary biogeographic and diversification patterns.Our results reveal that Carex originated in the late Eocene in E Asia,where it probably remained until the synchronous diversification of its main subgeneric lineages during the late Oligocene.E Asia is supported as the cradle of Carex diversification,as well as a< | Santiago Martin-Bravo Pedro Jimenez-Mejias Tamara Villaverde Marcial Escudero Marlene Hahn Daniel Spalink Eric H.Roalson Andrew L.Hipp the Global Carex Group Carmen Benitez-Benitez Leo P.Bruederle Elisabeth Fitzek Bruce A.Ford Kerry A.Ford Mira Gamer Sebastian Gebauer Matthias H.Hoffmann Xiao-Feng Jin Isabel Larridon Etienne Ldveilld-Bourret Yi-Fei Lu Modesto Luceno Enrique Maguilla Jose Ignacio Marquez-Corro Monica Miguez Robert Naczi Anton A.Reznicek Julian R.Starr | 2019 | Journal of Systematics and Evolution2019，57，6： | 6 |
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