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| 1 | Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer显示文摘Objective: To screen and analyze key express sequence tags (ESTs) which were differentially displayed in every period of SD rats' primary hepatic carcinoma and reveal the molecular mechanism of carcinogenesis. Methods: Using diethylnitrosamine (DENA) as a cancerigenic agent, animal models with different phases of primary hepatic cancer were constructed in SD rats. Rats were respectively sacrificed at d 14, d 28, d 56, d 77, d 105 and d 112 after the rats received DENA by gavage, then the livers were harvested. One part of the livers was classified according to their pathological changes, while the other was reserved for molecular mechanism studies on hepatocarcinogenesis. The differentially expressed genes were isolated from both normal and morbid tissues by mRNA differential display technique (DDRT-PCR). After the fragments were sequenced, bioinformatics were used to analyze the results. Results: Twelve differentially expressed cDNA fragments were obtained. Nine fragments had the homology with known cDNA clones, especially EST-7 was similar to BN/SsNHsdMCW mitochondrion gene and the identity was 100% which suggested EST-7 may be the part of BN/SsNHsdMCW mitochondrion gene. In contrast, other three fragments (EST-1, EST-3 and EST-5) had extremely low identity to any genes registered in GENBANK databases. Conclusions: BN/SsNHsdMCW mitochondrion gene was expressed in different periods of hepatocarcinogenesis. Moreover, EST-1, EST-3 and EST-5 were suggested to contribute to the development of rat hepatocarcinogenesis, and thus may be candidates of new targets of oncogenes or cancer suppressor genes. | Dandan Liu Lijuan Zhi Mingxia Ma Dan Qiao Meijuan Wang Yawei Wang Baijie Jin Anqi Li Guting Liu Yiqing Zhang Yanyan Song Hongxu Zhang | 2013 | Chinese Journal of Cancer Research2013，25，1： | 9 |
| 2 | Distributed Cooperative Control Algorithm for Multi-UAV Mission Rendezvous显示文摘Multiple unmanned aerial vehicles(UAVs)cooperative operation is the main form for UAVs fighting in battlefield,and multi-UAV mission rendezvous is the premise of cooperative reconnaissance and attack missions.We propose a rendezvous control strategy,which divides the rendezvous process into two parts:The loose formation rendezvous and the close formation rendezvous.In the first stage,UAVs are supposed to reach the specific target locations simultaneously and form a loose formation.A distributed control strategy based on first-order consensus algorithm is presented to achieve this goal.Then the second stage is designed based on the second-order consensus algorithm to complete the transition from the loose formation to the close formation.This process needs the speeds and heading angles of UAVs to reach an agreement.Besides,control algorithms with a virtual leader are proposed,by which the formation states can reach a specific value.Finally,simulation results show that the control algorithms are capable of realizing the mission rendezvous of multi-UAV and the consistence of UAVs′final states,which verify the effectiveness and feasibility of the designed control strategy. | Liu Guoliang Xing Dongjing Hou Jianyong Jin Guting Zhen Ziyang | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，6： | 5 |
| 3 | Multi-target Collaborative Combat Decision-Making by Improved Particle Swarm Optimizer显示文摘A decision-making problem of missile-target assignment with a novel particle swarm optimization algorithm is proposed when it comes to a multiple target collaborative combat situation.The threat function is established to describe air combat situation.Optimization function is used to find an optimal missile-target assignment.An improved particle swarm optimization algorithm is utilized to figure out the optimization function with less parameters,which is based on the adaptive random learning approach.According to the coordinated attack tactics,there are some adjustments to the assignment.Simulation example results show that it is an effective algorithm to handle with the decision-making problem of the missile-target assignment(MTA)in air combat. | Ding Yongfei Yang Liuqing Hou Jianyong Jin Guting Zhen Ziyang | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，1： | 4 |
| 4 | Mechanisms of ischemic preconditioning显示文摘 | Yarimizu K Gute DC | 1997 | Shock1997，8，： | 1 |
| 5 | A foundation for representing and querying moving objects显示文摘 | GUTING R H | 2000 | ACM Transactions on Database Systems2000，25，1： | 1 |
| 6 | A foundation for Representing and Querying Moving Objects显示文摘 | R H Guting | 2000 | ACM Transactions on Database Systems2000，25，1： | 1 |
| 7 | Fuzzy spatial objects:An algebra implementation in SECONDO显示文摘 | Thomas Behr Ralf Hartmut Guting | 2005 | Proceedings of the2005，21，： | 1 |
| 8 | Modeling the ice filling process of rectangular thermal energy storage tanks with multiple ice makers显示文摘 | Gute G D S W Chandrasekharan J Saunders CK | 1995 | ASHRAE Transactions: Research1995，101，1： | 1 |
| 9 | A foundation for representing and querying moving objects显示文摘 | Guting R H | 2000 | ACM Transactions on Database Systems2000，25，1： | 1 |
| 10 | Indexing the trajectories of moving objects in networks显示文摘 | de Almeida V T Guting R H | 2005 | Geolnformatica2005，9，1： | 1 |
| 11 | An introduction to spatial database systems显示文摘 | Guting R | 1994 | VLDB Journal1994，3，4： | 1 |
| 12 | Modeling and Querying Moving Objects in Networks显示文摘 | Guting R H de Almeida V T | 2006 | The Interna tional Journal on Very Large DataBases2006，15，2： | 1 |
| 13 | ICEPAK- modeling the ice-filling and ice-melting processes of thermal energy storage tanks 显示文摘 | Stewart W E Jr Gute G D Saunders C K | 1995 | ASHRAE Transactions1995，101，1： | 1 |
| 14 | PR-39,a proline/aiginine-rich antimicrobial peptide, prevents post ischemic mixrovascular dysfunction显示文摘 | Korthius J R Gute C D Biecha F | 1999 | Am J Physiol1999，277，： | 1 |
| 15 | Mechanisms ofischemic preconditioning显示文摘 | Ishida T Yarimizu K Gute DC | 1997 | Shock1997，8，2： | 1 |
| 16 | Cellular mechanisms of acute versus delayed preconditioning显示文摘 | Korthuis R Gute D Cepinskas G | 1998 | Pathophysiology1998，5，1： | 1 |
| 17 | An Introduction to Spatial Database Systerns 显示文摘 | GUTING R H | 1994 | VLDB Journal1994，3，4： | 1 |
| 18 | Concentration-dependent effects of bradykinin on leukocyte recruitment and venular hemodynamics in rat mesentery显示文摘 | Shigematsu S Ishida S Gute DC | 1999 | Am J Physiol1999，277，12： | 1 |
| 19 | Inflammatory responses to isehemia and reperfusion in skeletal musele显示文摘 | Gute DC Ishida T Yarimizu K | 1998 | Mol Cell Biochem1998，179，12： | 1 |
| 20 | Ischemic preconditioning attenuates capillary no-reflow induced by ischemia and reperfusion显示文摘 | Jerome S Akimitsu T Gute D | 1995 | Am J Physiol1995，268，5： | 1 |
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