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| 1 | Magnetic resonance imaging:Is there a role in clinical management for acute ischemic colitis?显示文摘AIM:To validate the utility of magnetic resonance imaging(MRI) for the clinical management of acute ischemic colitis(IC).METHODS:This is a magnetic resonance(MR) prospective evaluation of 7 patients who were proved to have acute IC on the basis of clinical,endoscopic and computed tomography(CT) findings and who were imaged in our institution between February 2011 and July 2012.The mean age of the patients was 72.28 years.Abdominal CTs were obtained using a 64-detector row configuration for all patients with un-enhanced and contrast-enhanced scans,in the late arterial phase(start delay 45-50 s) and in the portal venous phase(start delay 70-80 s).The MR examinations were performed using a 1.5T superconducting magnet,using Fast Imaging Employing Steady State Acquisition and T2-weighted fast-recovery fast-spin echo sequences in axial and coronal plane.CT and MRI examinations were analysed for the presence of colonic abnormalities and associated findings.RESULTS:Segmental involvement was seen in 6 patients(85.71%),with a mean length of involvement of 412 mm(range 145.5-1000 mm).Wall thickness varied between 6 mm and 17.5 mm(mean 10.52 mm) upon CT examinations and from 5 to 15 mm(mean 8.8 mm) upon MR examinations.The MRI appearance of the colonic wall varied over the time:TypeⅠappearance with a 3 layer sandwich sign was seen in 5 out of 12 examinations(41.66%),patients underwent MR within a mean of 36 h(ranging from 1 to 54 h) after the CT examination.Type Ⅱ and Ⅲ appearance with a 2 layer sign,was seen in 4 examinations(33.33%),patients underwent MR within a mean of 420.5 h(ranging from 121 to 720 h) after the CT examination.In the remaining three MRI examinations,performed within a mean of 410 h(ranging from 99.5 to 720 h) the colonic wall appeared normal.CONCLUSION:MRI,only using precontrast images,may be used as a substitute for invasive procedures in diagnosis and follow-up of acute IC. | Maria Antonietta Mazzei Susanna Guerrini Nevada Cioffi Squitieri Giusi Imbriaco Raffaele Chieca Serenella Civitelli Vinno Savelli Francesco Giuseppe Mazzei Luca Volterrani | 2013 | World Journal of Gastroenterology2013，19，8： | 5 |
| 2 | Incidental extravascular findings in computed tomographic angiography for planning or monitoring endovascular aortic aneurysm repair: Smoker patients, increased lung cancer prevalence?显示文摘AIM To validate the feasibility of high resolution computed tomography(HRCT) of the lung prior to computed tomography angiography(CTA) in assessing incidental thoracic findings during endovascular aortic aneurysm repair(EVAR) planning or follow-up.METHODS We conducted a retrospective study among 181 patients(143 men, mean age 71 years, range 50-94) referred to our centre for CTA EVAR planning or followup. HRCT and CTA were performed before or after 1 or 12 mo respectively to EVAR in all patients. All HRCT examinations were reviewed by two radiologists with 15 and 8 years experience in thoracic imaging. The results were compared with histology, bronchoscopy or follow-up HRCT in 12, 8 and 82 nodules respectively. RESULTS There were a total of 102 suspected nodules in 92 HRCT examinations, with a mean of 1.79 nodules per patient and an average diameter of 9.2 mm(range 4-56 mm). Eightynine out of 181 HRCTs resulted negative for the presence of suspected nodules with a mean smoking history of 10 pack-years(p-y, range 5-18 p-y). Eighty-two out of 102(76.4%) of the nodules met criteria for computed tomography follow-up, to exclude the malignant evolution. Of the remaining 20 nodules, 10 out of 20(50%) nodules, suspected for malignancy, underwent biopsy and then surgical intervention that confirmed the neoplastic nature: 4(20%) adenocarcinomas, 4(20%) squamous cell carcinomas, 1(5%) small cell lung cancer and 1(5%) breast cancer metastasis); 8 out of 20(40%) underwent bronchoscopy(8 pneumonia) and 2 out of 20(10%) underwent biopsy with the diagnosis of sarcoidosis.CONCLUSION HRCT in EVAR planning and follow-up allows to correctly identify patients requiring additional treatments, especially in case of lung cancer. | Maria Antonietta Mazzei Susanna Guerrini Francesco Gentili Giuseppe Galzerano Francesco Setacci Domenico Benevento Francesco Giuseppe Mazzei Luca Volterrani Carlo Setacci | 2017 | World Journal of Radiology2017，9，7： | 3 |
| 3 | Inhibition of BACE1, the β-secretase implicated in Alzheimer’s disease, by a chondroitin sulfate extract from Sardina pilchardus显示文摘The pharmaceutical and anticoagulant agent heparin,a member of the glycosaminoglycan family of carbohydrates,has previously been identified as a potent inhibitor of a key Alzheimer’s disease drug target,the primary neuronalβ-secretase,β-site amyloid precursor protein cleaving enzyme 1(BACE1).The anticoagulant activity of heparin has,however,precluded the repurposing of this widely used pharmaceutical as an Alzheimer’s disease therapeutic.Here,a glycosaminoglycan extract,composed predominantly of 4-sulfated chondroitin sulfate,has been isolated from Sardina pilchardus,which possess the ability to inhibit BACE1(IC50[half maximal inhibitory concentration]=4.8μg/mL),while displaying highly attenuated anticoagulant activities(activated partial thromboplastin time EC50[median effective concentration]=403.8μg/mL,prothrombin time EC50=1.3 mg/mL).The marine-derived,chondroitin sulfate extract destabilizes BACE1,determined via differential scanning fluorimetry(ΔTm–5°C),to a similar extent as heparin,suggesting that BACE1 inhibition by glycosaminoglycans may occur through a common mode of action,which may assist in the screening of glycan-based BACE1 inhibitors for Alzheimer’s disease. | Courtney J.Mycroft-West Anthony J.Devlin Lynsay C.Cooper Patricia Procter Gavin J.Miller David G.Fernig Marco Guerrini Scott E.Guimond Marcelo A.Lima Edwin A.Yates Mark Andrew Skidmore | 2020 | Neural Regeneration Research2020，15，8： | 2 |
| 4 | The effects of nociceptin/orphanin FQ, a highly potent agonist of the NOP receptor,on in vitro and in vivo gastrointestinal functions显示文摘 | Broccardo M Linari G Guerrini R | 2005 | Peptides2005，26，9： | 1 |
| 5 | Quantitative molecular evaluation in autotransplant programs for follicular lymphoma: efficacy of in vivo purging by Rituximab显示文摘 | Galimberti S Guerrini F Morabito F | 2003 | Bone Marrow Transplant2003，32，1： | 1 |
| 6 | Gastrointestinal effects of intraeerebroventricularly injected nociceptin/orphanin FQin rats显示文摘 | Broccardo M Guerrini R Petrella C | 2004 | Peptides2004，25，6： | 1 |
| 7 | Epilepsy and malformations of the cerebral cortex显示文摘 | Guerrini R Sicca F Parmeggiani L | 2003 | Epileptic Disord2003，5，2： | 1 |
| 8 | Epilepsy and malformations of the cerebral cortex显示文摘 | GUERRINI R SICCA F PARMEGGIANI L | 2003 | Epileptic Disord2003，5，2： | 1 |
| 9 | Quantitative molecular evaluation in autotransplant programs for follicular lymphoma:efficacy of in vivo purging by Rituximab显示文摘 | Galimberti S Guerrini F Morabito F | 2003 | Bone Marrow Transplant2003，32，1： | 1 |
| 10 | The effects of nociceptin/orphanin FQ,a highly potent agoniat of the NOP receptor,on in vitro and in vivo gastrointestinal functions显示文摘 | Broccardo M Linari G Guerrini R | 2005 | Peptides2005，26，9： | 1 |
| 11 | Opioid Deltorphin C analogues containing cis- or trans-2- or 3- or 4-aminocyclohexanecarboxylic acid residues 显示文摘 | Marastoni M Guerrini R Balboni G | 1999 | ArzneimForsch1999，49，1： | 1 |
| 12 | Malformations of cortical development and epilepsy显示文摘 | Leventer RJ Guerrini R Dobyns WB | 2008 | Dialogues Clin Neurosci2008，10，： | 1 |
| 13 | Human osteoc-Jast- poor osteopetrosis with hypogammaglobulinemia due to TNFRSFIIA(RANK)mutations显示文摘 | Guerrini MM Sobacchi C Cassani B | 2008 | Am J Hum Cenet2008，83，： | 1 |
| 14 | Gastrointestinal effects of intracerebreventricularly injected nociceptin/orphanin FQ in rats显示文摘 | Broccardo M Guerrini R Petrella C | 2004 | Peptides2004，25，6： | 1 |
| 15 | Antiepileptic drug-induced wors- ening of seizures in children 显示文摘 | Guerrini R Belmonte A Genton P | 1998 | Epilepsia1998，39，3： | 1 |
| 16 | Safety and tolerability of antiepileptic drug treatment in children with epilepsy显示文摘 | Guerrini R Zaceara G |a Marca G | 2012 | Drug Saf2012，35，7： | 1 |
| 17 | Safety andtolerability of antiepileptic drug treatment in children withepilepsy 显示文摘 | GUERRINI R ZACCARA G LA MARCA G | 2012 | Drug safety2012，35，7： | 1 |
| 18 | Bacterial algal interactions in polysaccharide production显示文摘 | Guerrini F Mazzotti A Boni L | 1998 | Aquat Microb Ecol1998，15，： | 1 |
| 19 | The congenital bilateral perisylvian syndrome:study of 31 patients显示文摘 | Andermann F Guerrini R | 1993 | Lancet1993，341，3： | 1 |
| 20 | Visual sensitivity and epilepsy: A proposed terminology and classification for clinical and EEG phenomenology 显示文摘 | Kasteleijn - Noslst Trenite DG Guerrini R Binnie C | 2001 | Epilepsia2001，42，5： | 1 |
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