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| 1 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 2 | Directed duet excision by using mammary ductoscopy in patients with pathologic nipple discharge显示文摘 | Dietz JR Growe JP Grundfest S | 2002 | Surgery2002，13，2： | 1 |
| 3 | Predictive value of C D lymphocyte numbers for the development of opportunistic infections and malignancies in HIV-infected persons 显示文摘 | Growes S M Carlin J B Stewart K L | 1991 | J Acquir Immune Defic Sydr1991，4，： | 1 |
| 4 | Iron catalyst for CVD of methane on carbon fibers显示文摘 | GROW D T | 1992 | Carbon1992，30，2： | 1 |
| 5 | Thermal analysis of PPM-focused rod-supported TWT helix structures显示文摘 | R Crivello R W Grow | 1988 | IEEE ED1988，35，10： | 1 |
| 6 | Compact, High Performance Surface Plasmon Resonance Imaging System 显示文摘 | Chinowsky T M Grow M S Johnston K S | 2007 | Biosensors and Bioelectronics2007，22，90： | 1 |
| 7 | A phylogenetic analysis of Pisum based on morphological characters, allozyme and RAPD markers显示文摘 | Hoey B K Growe K R Jones V M | 1996 | Theoretical and Applied Genetics1996，92，： | 1 |
| 8 | Oral contraceptives maintain a very thin endometrium before operative hysteroscopy显示文摘 | Grow DR Iromloo K | 2006 | Fertil Steril2006，85，1： | 1 |
| 9 | Anxiety, depression, and quality of life in caregivers of patients with caglcer in late palliative phase显示文摘 | Grow EK DahlAA Mourn T | 2005 | Ann Oneol2005，16，7： | 1 |
| 10 | Pathogenesis of hypoxic-ischemic cerebral injury in the term infant:current concepts显示文摘 | Grow J Barks JD | 2002 | Clin Perinatol2002，29，4： | 1 |
| 11 | The pesticide methoxychlor disrupts the fusion of myoblasts into myotubes in skeletal muscle cell culture显示文摘 | Grow W A | 2002 | Toxicol Appl Pharmacol2002，179，10： | 1 |
| 12 | Randomised controlled trial of prevention of falls in people aged > or = 75 with severe visual impairment:the VIP trial显示文摘 | Campbell AJ Robertson MC La Grow S J | 2005 | BMJ2005，331，7520： | 1 |
| 13 | Canal clearance in burst fractures using the AO internal fixateur 显示文摘 | Gertzbein SD Growe DJ Fazi M | 1992 | Spine1992，17，5： | 1 |
| 14 | Evaluation of two live, cold- passaged, temperature - sensitive respiratory syncytial virus vaccines in chimpanzees and in human adults, infants, and children 显示文摘 | Karron RA Wright PF Growe JE | 1997 | J Inf Dis1997，176，6： | 1 |
| 15 | New biochip technology for label-frae detection of pathogens and their toxins 显示文摘 | Grow AE Wood LL Claycomb JL | 2003 | J Microbiol Methods2003，53，2： | 1 |
| 16 | 显示文摘 | Grow WB Moreb JS Roque D | 2002 | Bone Marrow Transplant2002，29，： | 1 |
| 17 | Depression in older people: visual impairment and subjective ratings of health显示文摘 | HAYMAN KJ KERSE NM LA GROW SJ | 2007 | Optom Vis Sci2007，84，11： | 1 |
| 18 | Orderly structure in jet turbulence显示文摘 | Grow S C Champagne F H | 1971 | Fluid Mech1971，48，： | 1 |
| 19 | 显示文摘 | Li X Jiang B Pan B: Biotranstbrmation of phenylpyruvic acid to phenyllactic acid by growing and resting cells of a Lactobacillus sp | 2007 | Biotechnol Lett2007，29，： | 1 |
| 20 | Motivational predictors of weight loss and weight-loss maintenance显示文摘 | WILLIAMS G C GROW V M FREEDMAN Z R | 1996 | Journal of Personality and Social Psychology1996，70，1： | 1 |
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