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| 1 | Direct laser writing of volumetric gradient index lenses and waveguides显示文摘Direct laser writing(DLW)has been shown to render 3D polymeric optical components,including lenses,beam expanders,and mirrors,with submicrometer precision.However,these printed structures are limited to the refractive index and dispersive properties of the photopolymer.Here,we present the subsurface controllable refractive index via beam exposure(SCRIBE)method,a lithographic approach that enables the tuning of the refractive index over a range of greater than 0.3 by performing DLW inside photoresist-filled nanoporous silicon and silica scaffolds.Adjusting the laser exposure during printing enables 3D submicron control of the polymer infilling and thus the refractive index and chromatic dispersion.Combining SCRIBE’s unprecedented index range and 3D writing accuracy has realized the world’s smallest(15μm diameter)spherical Luneburg lens operating at visible wavelengths.SCRIBE’s ability to tune the chromatic dispersion alongside the refractive index was leveraged to render achromatic doublets in a single printing step,eliminating the need for multiple photoresins and writing sequences.SCRIBE also has the potential to form multicomponent optics by cascading optical elements within a scaffold.As a demonstration,stacked focusing structures that generate photonic nanojets were fabricated inside porous silicon.Finally,an all-pass ring resonator was coupled to a subsurface 3D waveguide.The measured quality factor of 4600 at 1550 nm suggests the possibility of compact photonic systems with optical interconnects that traverse multiple planes.SCRIBE is uniquely suited for constructing such photonic integrated circuits due to its ability to integrate multiple optical components,including lenses and waveguides,without additional printed supports. | Christian R.Ocier Corey A.Richards Daniel A.Bacon-Brown Qing Ding Raman Kumar Tanner J.Garcia Jorik van de Groep Jung-Hwan Song Austin J.Cyphersmith Andrew Rhode Andrea N.Perry Alexander J.Littlefield Jinlong Zhu Dajie Xie Haibo Gao Jonah F.Messinger Mark L.Brongersma Kimani C.Toussaint Jr Lynford L.Goddard Paul V.Braun | 2020 | Light(Science & Applications)2020，9，1： | 6 |
| 2 | EGFR expression predicts BRCA1 status in patients with breast eancer显示文摘 | van Diest PJ van der Groep P van der Wall E | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 3 | Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma 显示文摘 | Bos R Van der Groep P Greijer AE | 2003 | Cancer2003，97，6： | 1 |
| 4 | Lack of lymphangiogenesis during breast carcinogenesis显示文摘 | Vleugel MM Bos R van der Groep P | 2004 | J Clin Pathol2004，57，7： | 1 |
| 5 | Lack of lym- phangiogenesis during breast carcinogenesis 显示文摘 | Vleugel MM Bos R van der Groep P | 2004 | J Clin Pathol2004，57，7： | 1 |
| 6 | Expression of hypoxia-inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast显示文摘 | Kuijper A van der Groep P van der Wall E | 2005 | Breast Cancer Res2005，7，5： | 1 |
| 7 | High fre- quency of HIF-lalpha overexpression in BRCA1 related breast cancer 显示文摘 | van der Groep P Bouter A Menko FH | 2008 | Breast Cancer Res Treat2008，111，3： | 1 |
| 8 | lack of lymphangiogenesis during breast carcinogenesis显示文摘 | Vleugel M M Bos R Van - der- Groep P | 2004 | Olin Pathol2004，57，7： | 1 |
| 9 | Up- regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 ( HIF-I ) 显示文摘 | Greijer A E van der Groep P Kemming D | 2005 | JPathol2005，206，3： | 1 |
| 10 | Levels of hypoxia -inducible facter-lalpha independently predict prognosis in patients with lymph node negative breast carcinoma显示文摘 | Bos R Van der Groep P Greijer AE | 2003 | Cancer2003，97，6： | 1 |
| 11 | Expression hypoxia - inducible factor - 1 alpha and its downstream targets in fibroepithelial tumors of the breast 显示文摘 | Kuijper A van der Groep P van der Wall E | 2005 | Breast Cancer Res2005，7，5： | 1 |
| 12 | Levels of hypoxia-inducible factor-1 alpha independently predict prognosis in patients with lymph node negative breast carcinoma 显示文摘 | Bos R van der Groep P Greijer AE | 2003 | Cancer2003，97，： | 1 |
| 13 | High frequency of HIF- 1alpha overexpression in BRCA1 related breast cancer显示文摘 | Groep P Bouter A Menko F H | 2008 | Breast Cancer Res Treat2008，111，3： | 1 |
| 14 | EGFR expression predicts BRCA1 status in patients with breast cancer 显示文摘 | van Diest PJ van der Groep P van der Wall E | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 15 | Lack oflymphangiogenesis during breast carcinogenesis 显示文摘 | VLEUGEL M M BOS R van der GROEP P | 2004 | J ClinPathol2004，57，7： | 1 |
| 16 | Hypoxia and angiogenesis in endometrioid endometrial carcinogenesis显示文摘 | Horree N Diest PJ van der Groep P | 2007 | Cell Oncol2007，29，3： | 1 |
| 17 | Levels of Hypoxla - Inducible Factor- la independently predict prognosis in patients with lymph node negative breast carcinoma 显示文摘 | Bos R van der Groep P Greijer A E | 2003 | Cancer2003，97，： | 1 |
| 18 | Pathology of hereditary breast cancer 显示文摘 | van der Groep P van der Wall E van Diest P | 2011 | Cell Oncol2011，34，2： | 1 |
| 19 | Hypoxia and angiogenesis in endometrioid endometrial carcinogenesis 显示文摘 | Horree N van Diest PJ van der Groep P | 2007 | Cell Oncol2007，29，3： | 1 |
| 20 | Subcel- lular FIH-1 expression patterns in invasive breast cancer in re- lation to HIF- lct expression 显示文摘 | Hyseni A van der Groep P van der Wall E | 2011 | Cell Oncol (Dordr)2011，34，6： | 1 |
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