|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Competition between TRAF2 and TRAF6 Regulates NF-κB Activation in Human B Lymphocytes显示文摘Objective To investigate the role of TNF receptor-associated factor 2 (TRAF-2) and TRAF6 in CD40-induced nuclear factor-κB (NF-κB) signaling pathway and whether CD40 signaling requires TRAF2. Methods Human B cell lines were transfected with plasmids expressing wild type TRAF2 or dominant negative TRAF2,TRAF2-shRNA,or TRAF6-shRNA. The activation of NF-κB was detected by Western blot,kinase assay,transfactor enzyme-linked immunosorbent assay (ELISA),and fluorescence resonance energy transfer (FRET). Analysis of the role of TRAF-2 and TRAF-6 in CD40-mediated NF-κB activity was examined following stimulation with recombinant CD154. Results TRAF2 induced activity of IκB-kinases (IKKα,IKKi/ε),phosphorylation of IκBα,as well as nuclear translocation and phosphorylation of p65/RelA. In contrast,TRAF6 strongly induced NF-κB activation and nuclear translocation of p65 as well as p50 and c-Rel. Engagement of CD154-induced nuclear translocation of p65 was inhibited by a TRAF6-shRNA,but conversely was enhanced by a TRAF2-shRNA. Examination of direct interactions between CD40 and TRAFs by FRET documented that both TRAF2 and TRAF6 directly interacted with CD40. However,the two TRAFs competed for CD40 binding. Conclusions These results indicate that TRAF2 can signal in human B cells,but it is not essential for CD40-mediated NF-κB activation. Moreover,TRAF2 can compete with TRAF6 for CD40 binding,and thereby limit the capacity of CD40 engagement to induce NF-κB activation. | Wen Zhang Xuan Zhang Xiao-li Wu Liu-sheng He Xiao-feng Zeng Amrie C. Grammer Peter E. Lipsky | 2010 | Chinese Medical Sciences Journal2010，25，1： | 5 |
| 2 | Sequence Stratigraphy and Rudist Facies Development of the Upper Barremian-Lower Cenomanian Platform, Northern Sinai, Egypt显示文摘The Lower Cretaceous sections in northern Sinai are composed of the Risan Aneiza(upper Barremian-middle Albian) and the Halal(middle Albian-lower Cenomanian) formations. The facies reflect subtle paleobathymetry from inner to outer ramp facies. The inner ramp facies are peritidal, protected to open marine lagoons, shoals and rudist biostrome facies. The inner ramp facies grade northward into outer ramp deposits. The upper Barremian-lower Cenomanian succession is subdivided into nine depositional sequences correlated with those recognized in the neighbouring Tethyan areas. These sequences are subdivided into 19 medium-scale sequences based on the facies evolution, the recorded hardgrounds and flooding surfaces, interpreted as the result of eustatic sea level changes and local tectonic activities of the early Syrian Arc rifting stage. Each sequence contains a lower retrogradational parasequence set that constituted the transgressive systems tracts and an upper progradational parasequence set that formed the highstand systems tracts. Nine rudist levels are recorded in the upper Barremian through lower Cenomanian succession at Gabal Raghawi. At Gabal Yelleg two rudist levels are found in the Albian. The rudist levels are associated with the highstand systems tract deposits because of the suitability of the trophic conditions in the rudist-dominated ramp. | Yasser SALAMA Michael GRAMMER Shaban SABER Soheir EL-SHAZLY Gouda ABDEL-GAWAD | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 3 |
| 3 | The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling显示文摘 | Myers M G Grammer T C Brooks J | 1995 | J Biol Chem1995，270，11： | 1 |
| 4 | The role of geophysics in the discovery and delineation of the Cosmos Nickel Sulphide Deposit, Leinster area, Western Australia 显示文摘 | Craven B Rovira T Grammer T | 2000 | Exploration Geophysics2000，31，： | 1 |
| 5 | Ionic mechanisms of electrical remodeling in human atrial fibrillation显示文摘 | Bosch RF Zeng X Grammer JB | 1999 | Cardiovasc Res1999，，： | 1 |
| 6 | Association between asym- metric dimethylarginine and neopterin in patients with and without angiographic coronary artery disease 显示文摘 | Murr C Meinitzer A Grammer T | 2009 | Scared J Immttnol2009，70，1： | 1 |
| 7 | Management of allergic bronchopulmo- nary aspergillosis : a review and update 显示文摘 | Mahdavinia M Grammer LC | 2012 | Ther Adv Respir Dis2012，6，3： | 1 |
| 8 | Ionic mechanisms of electrical remodeling in human atrial fibrillation显示文摘 | Bosch RF Zeng X Grammer JB | 1999 | Cardiovasc Res1999，44，： | 1 |
| 9 | Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions 显示文摘 | Grammer AC Slota R Fischer R | 2003 | J Clin Invest2003，112，10： | 1 |
| 10 | Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastie astrocytoma tumor biopsy samples 显示文摘 | Hecker TP Grammer JR Gillespie G | 2002 | Cancer Res2002，62，9： | 1 |
| 11 | Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus显示文摘 | Girschick H J Grammer A C Nanki T | 2002 | Arthritis Rheum2002，46，5： | 1 |
| 12 | Ionic mechanisms of electrical remodeling in human atrial fibrillation显示文摘 | Bosch RF Zeng X Grammer JB | 1999 | Cardiovasc Res1999，44，1： | 1 |
| 13 | Follicle-stimulating hormone/cAMP regulation of aromatase gene expression requires beta-catenin显示文摘 | Parakh TN Hernandez JA Grammer JC | 2006 | Proc Natl Acad Sci USA2006，103，12： | 1 |
| 14 | C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease:the LURIC study显示文摘 | Grammer TB Mrz W Renner W | 2009 | Eur Heart J2009，30，2： | 1 |
| 15 | Ionic mechanisms of electrical remodeling in human atrial fibrillation 显示文摘 | Bosch R F Zeng X R Grammer J B | 1999 | Cardiovasc Res1999，44，1： | 1 |
| 16 | Low-density lipoprotein receptor-related protein contributes to the antiangiogenic activity of thrombospondin-2 in a murine glioma model显示文摘 | Fears CY Grammer JR Stewart JE Jr | 2005 | Cancer Res2005，65，20： | 1 |
| 17 | Focal adhesion kinase enhances signaling through the She/extracellular sigual-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples显示文摘 | Hecker TP Grammer JR Gillespie GY | 2002 | Cancer Res2002，62，9： | 1 |
| 18 | High estradiol levels are associated with increased mortality in older men referred to coronary angiography显示文摘 | Lerchbanm E Pilz S Grammer TB | 2011 | Exp Clin Endoerinol Diabetes2011，119，8： | 1 |
| 19 | PDGF-and insulindependent pp70S6k activation mediated by phosphatidylinositol3-OH kinase显示文摘 | Chung J Grammer T C Lemon K P | 1994 | Nature1994，370，： | 1 |
| 20 | Molecular and electrophysiological evidence for remodeling of the L-type Ca2 + channel in persistent atrial fibrilla-tios in humans显示文摘 | Bosch RF Kuhlkamp V | 2000 | Z Kardiol2000，89，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员