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| 1 | Survival after inflammatory bowel disease-associated colorectal cancer in the Colon Cancer Family Registry显示文摘AIM: To investigate the survival of individuals with colorectal cancer (CRC) with inflammatory bowel disease (IBD-associated CRC) compared to that of individuals without IBD diagnosed with CRC. METHODS: Epidemiologic, clinical, and follow-up data were obtained from the Colon Cancer Family Registry (Colon CFR). IBD-associated cases were identified from self-report of physician diagnosis. For a subset of participants, medical records were examined to confirm self-report of IBD. Cox proportional hazards regression was applied to estimate adjusted hazard ratios (aHR) and 95%CI of mortality, comparing IBD-associated to non-IBD-associated CRC, adjusted for age at CRC diagnosis, sex, Colon CFR phase, and number of prior endoscopies. Following imputation to complete CRC stage information, adjustment for CRC stage was examined. RESULTS: A total of 7202 CRC cases, including 250 cases of IBD-associated CRC, were analyzed. Over a twelve year follow-up period following CRC diagnosis, 2013 and 74 deaths occurred among non-IBD associated CRC and IBD-associated CRC patients, respectively. The difference in survival between IBD-associated and non-IBD CRC cases was not statistically significant (aHR = 1.08; 95%CI: 0.85-1.36). However, the assumption of proportional hazards necessary for valid inference from Cox regression was not met over the entire follow-up period, and we therefore limited analyses to within five years after CRC diagnosis when the assumption of proportional hazards was met. Over this period, there was evidence of worse prognosis for IBD-associated CRC (aHR = 1.36; 95%CI: 1.05-1.76). Results were similar when adjusted for CRC stage, or restricted to IBD confirmed in medical records. CONCLUSION: These results support the hypothesis that IBD-associated CRC has a worse prognosis than non-IBD-associated CRC. | Scott V Adams Dennis J Ahnen John A Baron Peter T Campbell Steven Gallinger William M Grady Loic LeMarchand Noralane M Lindor John D Potter Polly A Newcomb | 2013 | World Journal of Gastroenterology2013，19，21： | 2 |
| 2 | Fragmentation of metal rings by electromagnetic loading 显示文摘 | Grady D E Benson D A | 1983 | Experimental Mechanics1983，23，4： | 1 |
| 3 | Mutation of the type H transforming growth factor-β receptor is coincident with the transformation of human colon adenomas to malignant carcinomas 显示文摘 | GRADY WM RAJPUT A MYEROFF L | 1998 | Cancer Res1998，58，14： | 1 |
| 4 | A time-domain procedure for locating switched capacitors in power distribution systems显示文摘 | Kim Jiseong Grady W M Arapostathis A | 2002 | IEEE Trans on Power Delivery2002，17，4： | 1 |
| 5 | Crystal and molecular structure of cephalotaxine p-bromobenzoate显示文摘 | Arora S K Bates R B Grady R A | 1974 | J Org Chem1974，39，： | 1 |
| 6 | Ultrastructural studies of diffuse axconal injury in human显示文摘 | CHRISTMAN C W GRADY M S WALKER S A | 1994 | J Neurotrauma1994，11，2： | 1 |
| 7 | Rapid control of a scabies outbreak at a tertiary care hospital without ward closure显示文摘 | Khan A O'Grady S Muller MP | 2012 | Am J Infect Control2012，40，5： | 1 |
| 8 | An investigation of harmonics attenuation and diversity among distributed single-phase power electronic loads显示文摘 | MANSOOR A GRADY W M CHOWDHURY A H | 1995 | IEEE Trans on Power Delivery1995，10，1： | 1 |
| 9 | A statistical analysis of the effect of electric vehicle battery charging on distribution system harmonic voltages显示文摘 | Staats P T Grady W M Arapostathis A | 1998 | IEEE Trans on Power Delivery1998，13，2： | 1 |
| 10 | Sub-tenon's injection for local anaesthes'a in posterior segment surgery 显示文摘 | LIHK Abouleish A Grady J | 2000 | Ophthalmolgy2000，107，： | 1 |
| 11 | Ultrastructural studies of diffuse axonal injury in humans 显示文摘 | Christman C W Grady M S Walker S A | 1994 | J Neurotrauma1994，11，2： | 1 |
| 12 | Links between purchase location and stable isotope ratios of bottled water, soda, and beer in the United States显示文摘 | Chesson L A Valenzuela L O O’Grady S P | 2010 | Journal of agricultural and food chemistry2010，58，12： | 1 |
| 13 | Survey of active line conditioning met homologies显示文摘 | Grady W M Samotyi M J Noyola A H | 2000 | 1EEE Transactions on Power Electronics2000，15，4： | 1 |
| 14 | Magnetic size determination for interacting fine particle systems 显示文摘 | Bradbury A Menear S 0' Grady K | 1984 | IEEE Transactions on Magnetics1984，，5： | 1 |
| 15 | An Alizarin red-based assay of mineralization by adherent ceils in culture: comparison with cetylpyridinium chloride extraction 显示文摘 | GREGORY C A GRADY G W PEISTER A | 2004 | Anal Bio- chem2004，329，1： | 1 |
| 16 | Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with mierosatellite unstable colon cancer 显示文摘 | Grady WM Rajput A Lutterbaugh JD | 2001 | Cancer Res2001，61，3： | 1 |
| 17 | COX-2 expression correlates with microvessel density in non-melanoma skin cancer from renal trans- plant recipients and immunocompetent individuals 显示文摘 | O'Grady A O'Kelly P Murphy GM | 2004 | Hum Pathol2004，35，12： | 1 |
| 18 | Improvement in quality of life outcomes 2 weeks after left ventricular assist device implantation显示文摘 | Grady KL Meyer P Mattea A | 2001 | J Heart Lung Transplant2001，20，： | 1 |
| 19 | Passive im- munization of Pacific herring Clupea pallasii against viral hemorrhagic septicemia显示文摘 | Hershberger P K Gregg J L Grady C A | 2011 | J Aquat Anim Health2011，23，3： | 1 |
| 20 | How should health be defined?显示文摘 | Jadad A R Grady L | 2008 | BMJ2008，337，24： | 1 |
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