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| 1 | Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease显示文摘Hepatitis B virus(HBV) infection is a dynamic state ofinteractions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B(CHB) infection have shown an association between active viral replication and adverse clinical outcomes such as cirrhosis and hepatocellular carcinoma. The goal of therapy for CHB is to improve quality of life and survival by preventing progression of the disease to cirrhosis, decompensation, end-stage liver disease, hepatocellular carcinoma(HCC) and death. This goal can be achieved if HBV replication is suppressed in a sustained manner. The accompanying reduction in histological activity of CHB lessens the risk of cirrhosis and of HCC, particularly in non-cirrhotic patients. However, CHB infection cannot be completely eradicated, due to the persistence of covalently closed circular DNA in the nucleus of infected hepatocytes, which may explain HBV reactivation. Moreover, the integration of the HBV genome into the host genome may favour oncogenesis, development of HCC and may also contribute to HBV reactivation. | Francesco Paolo Russo Kryssia Rodríguez-Castro Laura Scribano Giorgia Gottardo Veronica Vanin Fabio Farinati | 2015 | World Journal of Hepatology2015，7，8： | 10 |
| 2 | Dispersive liquid-liquid microextraction,an effective tool for the determination of synthetic cannabinoids in oral fluid by liquid chromatography-tandem mass spectrometry显示文摘In the present work,dispersive liquid-liquid microextraction(DLLME)was used to extract six synthetic cannabinoids(JWH-018,JWH-019,JWH-073,JWH-200,or WIN 55,225,JWH-250,and AM-694)from oral fluids.A rapid baseline separation of the analytes was achieved on a bidentate octadecyl silica hydride phase(Cogent Bidentate C18;4.6 mm×250 mm,4μm)maintained at 37℃,by eluting in isocratic conditions(water:acetonitrile(25:75,V/V)).Detection was performed using positive electrospray ionization-tandem mass spectrometry.The parameters affecting DLLME(pH and ionic strength of the aqueous phase,type and volume of the extractant and dispersive solvent,vortex and centrifugation time)were optimized for maximizing yields.In particular,using 0.5 mL of oral fluid,acetonitrile(1 mL),was identified as the best option,both as a solvent to precipitate proteins and as a dispersing solvent in the DLLME procedure.To select an extraction solvent,a low transition temperature mixture(LTTM;composed of sesamol and chlorine chloride with a molar ratio of 1:3)and dichloromethane were compared;the latter(100μL)was proved to be a better extractant,with recoveries ranging from 73%to 101%by vortexing for 2 min.The method was validated according to the guidelines of Food and Drug Administration bioanalytical methods:intra-day and inter-day precisions ranged between 4%and 18%depending on the spike level and analyte;limits of detection spanned from 2 to 18 ng/mL;matrixmatched calibration curves were characterized by determination coefficients greater than 0.9914.Finally,the extraction procedure was compared with previous methods and with innovative techniques,presenting superior reliability,rapidity,simplicity,inexpensiveness,and efficiency. | Pierpaolo Tomai Alessandra Gentili Roberta Curini Rossella Gottardo Franco Tagliaro Salvatore Fanali | 2021 | Journal of Pharmaceutical Analysis2021，11，3： | 4 |
| 3 | Effects of transient cerebral ischmia on glial fibrillary acidic protein phosphorylation and immunocontent in rat hippocampus显示文摘 | Valentim LM Michalowski CB Gottardo SP | 1999 | Neurosci1999，91，： | 2 |
| 4 | A visfatin promoter pllymorphism is associated with low-grade inflammation and type 2 diabetes显示文摘 | ZHANG Y Y GOTTARDO L THOMPSON R | 2006 | Obesity2006，14，12： | 1 |
| 5 | Micro-RNA profiling inkidney and bladder cancers显示文摘 | Gottardo F Liu C G Ferracin M | 2007 | Urol Oncol2007，25，： | 1 |
| 6 | A visfatin promoter polymorphism is associated with low-grade Inflammation and Type 2 Diabetes显示文摘 | Zhang YY Gottardo L Thompson R | 2006 | Obesity2006，14，12： | 1 |
| 7 | Screening for synthetic cannabinoids in hair by using LC-QTOF MS: A new and powerful approach to study the penetration of these new psychoactive substances in the population显示文摘 | Gottardo R Sorio D Musile G | 2014 | Medicine Science and the Law2014，54，1： | 1 |
| 8 | Liquid crystal infiltration of complex dielectrics显示文摘 | Gottardo S Wiersma D S Vos W L | 2003 | Physica B:Condensed Matter2003，338，1： | 1 |
| 9 | Mi- ero-RNA profiling in kidney and bladder eancers 显示文摘 | GOTTARDO F LIU C G FERRACIN M | 2007 | Urol Oncol2007，25，： | 1 |
| 10 | Broad-spectrum toxicological analysis of hair based on capillary zone electrophoresis- time-of-flight mass spectrometry显示文摘 | Gottardo R Fanigliulo A Bortolotti F Paoli GD Pascali JP Tagliaro F | 2007 | Journal of Chromatography A2007，，1159： | 1 |
| 11 | Gradient vector flow fast geometric active contours 显示文摘 | Paragios N Gottardo O Ramesh V | 2004 | IEEE Transactions on Pattern Analysis and Machine Intelligence2004，26，3： | 1 |
| 12 | Micro-RNA profiling in kidney and bladder cancers 显示文摘 | Gottardo F Liu CG Ferracin M | 2007 | Urol Oncol2007，25，5： | 1 |
| 13 | Micro-RNA profiling in kid- ney and bladder cancers显示文摘 | Gottardo F Liu CG Ferracin M | 2007 | Urol Onco12007，25，5： | 1 |
| 14 | Micro-RNA profiling in kidney and bladder cancers显示文摘 | Gottardo F Liu CG Ferracin M | 2007 | Urol Oncol2007，25，5： | 1 |
| 15 | Does stocking density modify affective state in pigs as assessed by cognitive bias, behavioural and physiological parameters? 显示文摘 | SCOLLO A GOTTARDO F CONTIERO B | 2014 | Appl Anim Behav Sci2014，，153： | 1 |
| 16 | Rapid analysis of caf-feine in'smart drugs'and'energy drinks'by microemul-sion electrokinetic chromatography(MEEKC)显示文摘 | Liotta E Gottardo R Seri C | 2012 | Foren-sic Sci Int2012，220，13： | 1 |
| 17 | A visfatin promoter polymorphism is associated with low-grade inflammation and type 2 diabetes显示文摘 | Zhang YY Gottardo L Thompson R | 2006 | Obesity2006，14，12： | 1 |
| 18 | Current therapy for medulloblastoma 显示文摘 | Gottardo NG Gajjar A | 2006 | Curr Treat Options Neurol2006，8，4： | 1 |
| 19 | The provision of drinking water to veal calves for welfare purposes显示文摘 | F Gottardo S Mattiello G Cozzi E Canali | 2002 | Journal of Animal Science2002，80，9： | 1 |
| 20 | Adrenomedullin and Calcitonin gene-related peptide inhibit Aidosterone secretion in rats, acting via a common receptor 显示文摘 | Mazzocchi G Rebuffat P Gottardo G | 1996 | Life Sci1996，58，10： | 1 |
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