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| 1 | Long-term prognostic impact of circulating tumour cells in gastric cancer patients显示文摘AIM To analyse the long-term prognostic impact of circulating tumour cells(CTCs) in gastric cancer patients who underwent surgery. METHODS A 7.5-m L peripheral vein blood sample was obtained from each patient with treatment-negative gastric adenocarcinoma before surgery. OBP-401, a telomerasespecific, replication-selective, oncolytic adenoviral agent carrying the green fluorescent protein gene, was used to label CTCs. Correlations between the number of CTCs and clinical end points were evaluated. RESULTS The median follow-up period of the surviving patients with gastric cancer was 60 mo. The CTC number tended to increase concomitantly with disease progression. The overall survival of patients with more than five CTCs in 7.5-m L of peripheral blood was lower than that of patients with five or less CTCs, although the difference was not significant(P = 0.183). A significant difference in relapse-free survival was found between patients with more than five and those with five or less CTCs(P = 0.034).CONCLUSION A lower number of CTCs was correlated with higher relapse-free survival rates in patients. Detection of CTCs using OBP-401 may be useful for predicting prognosis in gastric cancer. | Hiroaki Ito Jun Sato Yukio Tsujino Noriko Yamaguchi Satoshi Kimura Keigo Gohda Katsuhiro Murakami Manabu Onimaru Tohru Ohmori Fumihiro Ishikawa Haruhiro Inoue | 2016 | World Journal of Gastroenterology2016，22，46： | 8 |
| 2 | 吕宋海峡ADCP观测的450m以浅水层内潮特征分析显示文摘应用2008年4月25日至9月26日的声学多普勒流速剖面仪(ADCP)的锚定测流资料,研究分析吕宋海峡上层海洋的内潮特征.谱分析和能量计算均显示在观测海区全日潮和半日潮为主要的能量频带,深度积分的全日潮频带总能量为31 kJ.m,在半日潮频带和高频带深度积分的总能量分别为6.9和3.4 kJ.m.谱分析结果显示:近惯性频率峰值仅出现在斜压分量.在66 m以浅深度,显著分潮(O1,K1,M2,MK3,M4)和近惯性频率分量都基本符合线性内波理论关系式E+(ω)/E-(ω)=(ω-f)2/(ω+f)2;然而,在其他观测深度,并非所有的主要分潮均满足上述线性内波能量一致性关系式.分析潮流的垂直结构和时间变化,结果表明:正压潮和内潮均为混合潮,潮日不等现象明显,显示了约14天的大潮/小潮周期变化.平行与垂直于陆架方向的K1和O1分潮的分量几乎相等,而M2和S2分潮则主要以波束形式向南海北部陆架传播.内潮幅度和相位均随时间变化,M2和S2垂向结构主要表现为第1模态,而K1和O1则接近于第2模态结构;在主温跃层附近,它们的短轴与长轴之比与f/ω的比值接近. | 廖光洪 袁耀初 Kaneko ARATA 杨成浩 陈洪 Taniguchi NAOKAZU Gohda NORIAKI Masanori MINAMIDATE | 2011 | 中国科学:地球科学2011，41，1： | 5 |
| 3 | Analysis of internal tidal characteristics in the layer above 450 m from acoustic Doppler current profiler observations in the Luzon Strait显示文摘The characteristics of internal tides in the upper layer of the Luzon Strait are investigated on the basis of direct-observation current data recorded on April 25 and September 26, 2008 by an acoustic Doppler current profiler. Spectral analysis and energy estimation show that the diurnals and semidiurnals carry most of the energy of internal tides. Values of the depth-integrated total energy E for the three frequency bands of diurnal, semidiurnal, and high frequencies are 31, 6.9, and 3.4 kJ·m, respectively. Near-inertial peaks are only present in the baroclinic component. The behavior of typical tidal frequencies (i.e., O1, K1, M2, MK3, and M4) and the near-inertial frequency is basically consistent with linear internal wave theory, which predicts E + (ω)/E (ω)=(ω f) 2 /(ω+f) 2 at depths above 66 m, while not all prominent tidal components coincide well with the relation of the linear internal wave field at other depths. Examinations of depth structures of the baroclinic tides and temporal variations show that the surface tides and internal tides are both of mixed type, having diurnal inequality and spring-neap fortnight periods. The K1 and O1 tides have comparable cross-and along-shelf components, while the M2 and S2 tides propagate toward the shelf in the northern South China Sea as wave beams. The amplitude and phase of internal tides vary with time, but M2 and S2 tides appear to have structures dominated by the first mode, while the K1 and O1 tides resemble second-mode structures. The minor to major axis ratios are close to expected values of f/ω in the thermocline. | LIAO GuangHong YUAN YaoChu Kaneko ARATA YANG ChengHao CHEN Hong Taniguchi NAOKAZU Gohda NORIAKI | 2011 | Science China Earth Sciences2011，54，7： | 4 |
| 4 | The circulation in the southern Huanghai Sea and northern East China Sea in June 1999显示文摘On the basis of hydrographic data and current measurement (the mooring system, vessel-mounted ADCP and toward ADCP) data obtained in June 1999, the circulations in the southern Huang-hai Sea (HS) and northern East China Sea (ECS) are computed by using the modified inverse method.The Kuroshio flows northeastward through eastern part of the investigated region and has the main coreat Section PN, a northward flow at the easternmost part of Section PN, a weaker anti-cyclonic eddy be-tween these two northward flows, and a weak cyclonic eddy at the western part of Section PN. Theabove current structure is one type of the current structures at Section PN in ECS. The net northwardvolume transport (VT) of the Kuroshio and the offshore branch of Taiwan Warm Current (TWCOB)through Section PN is about 26.2× 106 m3/s in June 1999. The VT of the inshore branch of TaiwanWarm CArrent (TWCIB) through the investigated region is about 0.4 × 106 m3/s. The Taiwan WarmCurrent (TWC) has much effect on the currents over the continental shelf. The Huanghai Sea CoastalCurrent (HSCC) flows southeastward and enters into the northwestern part of investigated region, andflows to turn cyclonically, and then it flows northeastward, due to the influences of the Taiwan WarmCurrent and topography. There is a cyclonic eddy south of Cheju Island where the Huanghai Sea CoastalCurrent flows to turn cyclonically. It has the feature of high dense and cold water. The uniform and coldwater is occurred in the layer from about 30 m level to the bottom between Stations C306 and C311 atthe northernmost Section C3. It is a southern part of the Huanghai Sea Cold Water Mass (HSCWM). | Arata Kaneko Noriaki Gohda | 2003 | Acta Oceanologica Sinica2003，22，3： | 2 |
| 5 | Cutting edge: TNFR- associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptorinducing IFN-beta (TRIF)-dependem pathway in TLR signaling显示文摘 | Gohda J Matsumura T Inoue J | 2004 | J Immuno]2004，173，5： | 1 |
| 6 | Identification of epistaticinteraction involved in obesity using the KK/Ta mouse as a type2 diabetes model: is Zn-?2-glycoproteinb-l a candidate gene forobesity?显示文摘 | GOHDA T MAKITA Y SHIKE T | 2003 | Diabetes2003，52，8： | 1 |
| 7 | CirculatingTNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes显示文摘 | Gohda T Niewczas MA Ficociello LH | 2012 | J Am Soc Nephrol2012，23，3： | 1 |
| 8 | Pioglitazone attenuates TGF-beta(1) -induction of fibronection synthesis and its splicing variant in human mesangial cells via of peroxisome proliferator-activated receptor(PPAR) gamma显示文摘 | MAEDA A HORIKOSHI S GOHDA T | 2005 | Cell Biol Int2005，29，6： | 1 |
| 9 | Circulating TNFreceptors 1 and 2 predict ESRD in type 2 diabetes显示文摘 | Niewczas MA Gohda T Skupien J | 2012 | J AmSoc Nephrol2012，23，3： | 1 |
| 10 | GC and GC - MS analysis of polychlorinated dioxins, dibenzofurans and aromatic hydrocarbons in fly ash from coal - burning works 显示文摘 | Gohda H Hatano Hanal H Miyaji T | 1993 | Chemophere1993，27，13： | 1 |
| 11 | Mindin: a novel marker for podocyte injury in diabetic nephropathy 显示文摘 | MURAKOSHI M TANIMOTO M GOHDA T | 2011 | Nephrology Dialysis Transplantation2011，26，7： | 1 |
| 12 | New damping materials composed of piezoelectric and electroconductive,particle-filled polymer composites:Effect of the eleetromeehanieal coupling faetor显示文摘 | Masao Sumita Hironori Gohda Shigeo Asai | 1991 | Maeromoleeular Rapid Communications1991，12，12： | 1 |
| 13 | New damping materials composed of piezoelectric and electro-conductive, particle-filled polymer composites: Effect of the electromechanical coupling factor显示文摘 | Sumita M Gohda H Asai S | 1991 | Makromol Chem Rapid Commun1991，12，12： | 1 |
| 14 | Serum cystatin C may predict the prognostic stages of patients with IgA nephropathy prior to renal biopsy显示文摘 | Tomino Y Suzuki S Gohda T | 2001 | Clin Lab Anal2001，15，1： | 1 |
| 15 | Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes显示文摘 | Niewczas MA Gohda T Skupien J | 2012 | J Am Soc Nephrol2012，23，3： | 1 |
| 16 | Single low-dose administration of human recombinant Hepatocyte Growth Factor Attenuates Intimal Hyper-plasia in a Balloon-Injured Rabbit Iliac Artery Model显示文摘 | Noguchi T Gohda M | 2000 | Circulation2000，101，： | 1 |
| 17 | Difficulty in diagnosing a case with apparent sequel cerebral sparganosi 显示文摘 | Murata K Abe T Gohda M | 2007 | Surg Neurol2007，67，4： | 1 |
| 18 | Immunohistochemical studies with a monoclonal antibody on the distribution of phosphophoryn in predentin and dentin 显示文摘 | Nakamura O Gohda E Ozawa M | 1985 | Calcif Tissue Int1985，37，5： | 1 |
| 19 | Difficulty in diagnosis of a case with apparent sequel cerebral sparganosis 显示文摘 | Murata K Abe T Gohda M ctal | 2007 | Surg Neurol2007，67，4： | 1 |
| 20 | NF-kappa B activation in development and progression of cancer 显示文摘 | INOUE J GOHDA J AKIYAMA T | 2007 | Cancer Sci2007，98，3： | 1 |
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