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| 1 | 新型偏心振动磨对碳酸钙粉料的机械力化学激活效应显示文摘评价了一种新型偏心振动磨研磨碳酸钙粉料时的机械力化学激活效应。与传统振动磨所产生的单向振动不同,这种新型磨机可以同时进行高振幅的多向振动,使碳酸钙粉料高度松散并经受研磨介质激烈机械粉碎和激活。通过X射线衍射仪、Fourier变换红外分光镜、扫描电镜、X射线光电子光谱仪和氮吸附比表面仪等实验手段对激活的粉料样品的晶体结构和颗粒表面进行了分析研究,用热重/差示热分析和差示扫描量热法检测了未激活和激活粉料的热效应。研究结果表明:机械力化学激活的碳酸钙颗粒的结晶度降低,颗粒表面能增加,热分解温度降低以及反应活性增强。激活颗粒的过余焓随着激活时间的增加而增加,过余焓与晶体形变有关。 | 王燕民 潘志东 李竟先 FORSSBERG E GOCK E | 2004 | 硅酸盐学报2004，32，4： | 5 |
| 2 | Bacteriolytic therapy of experimental pancreatic carcinoma显示文摘AIM:To investigate the effectiveness of Clostridium novyi(C.novyi)-NT spores for the treatment of established subcutaneous pancreatic tumor in the syngeneic,immunocompetent Panc02/C57Bl/6 model. METHODS:C.novyi-NT spores were applied intravenously to animals carrying established pancreatic tumors of three different sizes.Systemic immune responses in peripheral blood and spleen were examined by flow cytometry.Supplementary,cytotoxic activity of lymphocytes against syngeneic tumor targets was analyzed. RESULTS:Application of spores identified,that(1) small tumors(<150 mm 3 )were completely unaffected (n=10);(2)very large tumors(>450 mm3)responded with substantial necrosis followed by shrinkage and significant lethality most likely due to tumor lysis syndrome (n=6);and(3)an optimal treatment window exists for tumors of approximately 250 mm 3 (n=21).In this latter group,all tumor-bearing animals had complete tu-mor regression and remained free of tumor recurrence. In subsequent tumor rechallenge experiments a significant delay in tumor growth compared to the initial tumor cell inoculation was observed(tumor volume at day 28:197.8±87.3 mm 3 vs 500.1±50.9 mm3,P<0.05). These effects were accompanied by systemic activation of immune response mechanisms predominantly mediated by the innate arm of the immune system. CONCLUSION:The observed complete tumor regression is encouraging and shows that immunotherapy with C.novyi-NT is an interesting strategy for the treatment of pancreatic carcinomas of defined sizes. | Claudia Maletzki Michael Gock Ulrike Klier Ernst Klar Michael Linnebacher | 2010 | World Journal of Gastroenterology2010，16，28： | 3 |
| 3 | Increased efficiency of the vibratory milling Process with the eccentric vibratory mill显示文摘 | Gock E Kurrer K E | 1998 | Aufbereitungs-Technik1998，39，3： | 1 |
| 4 | Cutting edge:The transcription factor Kruppel-like factor 4 regulates the differentiation of Th17 cells independently of RORgammat显示文摘 | Lebson L Gocke A Rosenzweig J | 2010 | J Immunol2010，185，12： | 1 |
| 5 | Consideration on photochemical genotoxicity: Report of the international workshop on genotoxicity test procedures working group显示文摘 | Gocke E Muller L Guzzie PG | 2000 | Environ Mol Mutagen2000，35，3： | 1 |
| 6 | The human homologue of the Aspergillus nuclear migration gene nudC is preferentially expressed in di- viding cells and ciliated epithelia 显示文摘 | Gocke CD Osmani SA Miller BA | 2000 | Histochem Cell Bioll2000，114，4： | 1 |
| 7 | Nuclear receptors and autoimmune disease: the potential of PPAR agonists to treat multiple, sclerosis 显示文摘 | Racke MK Gocke AR Muir M | 2006 | Nutrion2006，136，7： | 1 |
| 8 | Therapeutic potential of small interfering RNA for central nervous system diseases显示文摘 | Lovett-Racke A E Cravens P D Gocke A R | 2005 | Arch Neurol2005，62，12： | 1 |
| 9 | Detection of tumor messenger mRNA in the serum of patients with malignant melanoma 显示文摘 | Benko FA Kwak LW Gocke CD | 1999 | Clin Cancer Res1999，5，： | 1 |
| 10 | Base Metals Recovery from Copper Smelter Slag by Oxidizing Leaching and Solvent Extraction 显示文摘 | Banza A N Gock E Kongolo K | 2002 | Hydrornetallurgy2002，67，13： | 1 |
| 11 | The nuclear migration gene NudC and human hematopoiesis显示文摘 | Gocke CD Reaman GH Stine C | 2000 | Leuk Lymphoma2000，39，56： | 1 |
| 12 | Eccentric vibratory mills - theory and practice 显示文摘 | Eberhard Gock Karl - Eugen Kurrer | 1999 | Powder Technology1999，105，10： | 1 |
| 13 | Eccentric vibratory mills: theory andpractice 显示文摘 | GOCK E KURRER K E | 1999 | Power technology1999，105，13： | 1 |
| 14 | In vitro studies of the killing of clinical isolates by povidone- iodine solution 显示文摘 | Gocke D J Ponticas S Pollack W | 1985 | J Hosp Infect1985，6，： | 1 |
| 15 | Serum bcl-2/IgH DNA in follicular lymphoma patients: a minimal residual disease marker 显示文摘 | Gocke C D Kopreski M S Benko F A | 2000 | Leuk Lymphoma2000，39，12： | 1 |
| 16 | A homologe of the fungal nuclear migration gene nudc is involved in nomal and malignant human hematopoiesis显示文摘 | Miller BA Zhang MY Gocke CD | 1999 | Exp Hematol1999，27，6： | 1 |
| 17 | Allogeneic sensitization is more effecvtive than xenogeneic sensitization in eliciting Galmediated skin graft rejection显示文摘 | Gock H Murray-Segal L Salvaris E | 2004 | Transplantation2004，77，5： | 1 |
| 18 | T-bet Regulates the fate of Th1 and Th17 lymphocytes in autoimmunity显示文摘 | Gocke AR Cravens PD Ben LH Hussain RZ Northrop SC Racke MK | 2007 | J Immunol2007，178，3： | 1 |
| 19 | The photomutagenicity of fluoroquinolones in tests for gene mutation, chromosomal aberration, gene conersion and DNA breakage显示文摘 | Chetelat AA Albertini S Gocke E | 1996 | Mutagenesis1996，11，5： | 1 |
| 20 | Hepatitis B immune globulin as a prophylactic measure for spouses exposed to acute type B hepatitis显示文摘 | Redeker AG Mosley JW Gocke DJ | 1975 | N Engl J Med1975，293，： | 1 |
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