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| 1 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 2 | 慢性难治性咳嗽的管理显示文摘慢性难治性咳嗽(chronic refractory cough,CRC)是指按照指南治疗后仍持续存在的咳嗽。至咳嗽专科门诊就诊的患者中,有20%~46%患有慢性难治性咳嗽,这些患者的生活质量及健康水平受到较大影响。许多术语被用来描述慢性难治性咳嗽,包括最近介绍的咳嗽高敏综合征。它的核心症状为局限于喉部附近区域的刺激性干咳。其症状并不仅限于咳嗽,还可包括癔球症、呼吸困难和发声困难。慢性难治性咳嗽与喉高敏综合征和慢性疼痛综合征具有相同的影响因素,这些相似点有助于我们理解其病理生理机制。慢性难治性咳嗽的病理生理学机制复杂,包括咳嗽反射敏感、中枢敏化、外周敏化和声带矛盾运动,通常发生于病毒感染之后。当导致慢性咳嗽的主要病因被排除(或治疗),而咳嗽症状对于治疗反应不佳时可以诊断为慢性难治性咳嗽。针对慢性难治性咳嗽的治疗,过去的十年中有一些新的发现,包括从功能性发声障碍治疗方法借鉴而来的言语病理学干预,以及作用于神经中枢的神经调节剂(例如加巴喷丁和普瑞巴林)的使用。此外,一些尚在研究中的潜在新型治疗方法也显示出较好的前景。 | Peter G Gibson,director Anne E Vertigan,speech pathologist 戴钰 梁志欣 | 2016 | 英国医学杂志中文版2016，0，6： | 3 |
| 3 | Fault-zone seals in siliciclastic strata of the Columbus Basin,offshore Trinidad显示文摘 | Gibson R G | 1994 | AAPG1994，78，9： | 2 |
| 4 | The adaptive significance of amphistomatic leaves 显示文摘 | Mott K A Gibson A G O'Leary J W | 1982 | Plant Cell Environ1982，9，： | 2 |
| 5 | CLUSTAL W:improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position specific gap penalties and weight matrix choice显示文摘 | Thompson J D Higgins D G Gibson T J | 1994 | Nucleic Acids Research1994，22，22： | 1 |
| 6 | RAID: high-performance, reliable secondary storage 显示文摘 | Chen P M Lee E K Gibson G A | 1994 | ACM Computing Surveys1994，26，2： | 1 |
| 7 | CLUSTAL W:improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice显示文摘 | Thompson J D Higgins D G Gibson T J | 1994 | Nucleic Acids Res1994，22，： | 1 |
| 8 | A new and highly efficient grubbs initiator for ring-opening metathesis polymerization显示文摘 | Robson D A Gibson V C Davies R G | 1999 | Macromolecules1999，32，19： | 1 |
| 9 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice 显示文摘 | Thompson J D Higgins D G Gibson T J | 1994 | Nucleic Acids Research1994，22，： | 1 |
| 10 | Assistive technology,telecare,and dementia:some implications of current policies and guidance显示文摘 | Woolham J Gibson G Clarke P | 2006 | Research Policy and Plarming2006，24，3： | 1 |
| 11 | Carbohydrate Preferences of Bifidobacterium Species Isolated from the Human Gut显示文摘 | Palframan R J Gibson G R Rastall R A | 2003 | Curt Issues Intest Microbiol2003，，4： | 1 |
| 12 | A Two-Stage Continuous Culture System to Study lle Effect of Supplemental Alpha-laatalbumin and Glycomacropetide on Mixed Cultures of Human Cut Bacte- ria Challenged with Enteropathogenic Escherichia Coil and Salmonella Serotype Typhimurium显示文摘 | BRUCK W M GRAVERHOLT G GIBSON R | 2003 | J Appl Mi erobiol2003，95，： | 1 |
| 13 | Eosinophilic bronchitis:clinical manifestations and implications for treatment显示文摘 | GIBSON P G FUJIMUR A M NIIMI A | 2002 | Thorax2002，57，2： | 1 |
| 14 | Identification ofa gene expression profile that discriminates indirect - acting genotoxins from direct - acting genotoxins 显示文摘 | HU T GIBSON D P CARR G J | 2004 | Murat Res2004，549，： | 1 |
| 15 | Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice显示文摘 | THOMPSON J D HIGGINS D G GIBSON T J | 1994 | Nucleic Acids Res1994，22，： | 1 |
| 16 | Relationships between ability and personality: Three hypotheses tested 显示文摘 | AUSTIN E J DEARY I J Gibson G J | 1997 | Intelligence1997，25，： | 1 |
| 17 | Network Attached Storage Architec- ture显示文摘 | Gibson G A van Meter R | 2000 | Communications of ACM2000，43，119： | 1 |
| 18 | Dietary modulation of the human colonicmicrobe: introducing the concept of Prebiotics显示文摘 | Gibson G R | 1995 | J Nutr1995，125，： | 1 |
| 19 | CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice 显示文摘 | Thompson J D Higgins D G Gibson T J | 1994 | Nucl Acids Res1994，22，： | 1 |
| 20 | In vitro studies on colo- nization resistance of the human gut microbiota to Candida albicans and the effects of tetracycline and Lactobacillus plantarum LPK显示文摘 | Payne S Gibson G Wynne A | 2003 | Curr Issues Intest Microbiol2003，4，1： | 1 |
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