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| 1 | Intermedin^(1-53)保护异丙基肾上腺素诱导的心肌损伤显示文摘目的在异丙基肾上腺素(isoproterenol,ISO)诱导的大鼠急性心肌损伤的模型上探讨Intermedin153(IMD153)对心肌损伤的保护作用。方法用ISO建立大鼠缺血损伤模型,观察IMD153对心脏功能和心肌组织损伤影响;半定量RTPCR检测心室肌降钙素受体样受体(calcitoninreceptorlikereceptor,CL)、受体活性修饰蛋白(receptoractivitymodifyingprotein,RAMP)1/2/3的mRNA表达水平;放射免疫法测定心肌cAMP的含量和放射配基法测定心肌浆膜IMD受体结合位点。结果与对照组比较ISO组大鼠的左室内压变化速率(±LVdp/dtmax)分别降低23%和44%(均P<0.01),左室舒张末压(leftventricularenddiastolicpressure,LVEDP)增高7.8倍(P<0.01),心室肌CL、RAMP1/2/3的mRNA水平均明显上调(除RAMP2P<0.05,均P<0.01),ISO组心肌浆膜IMD受体Bmax值升高118%〔(83.05±5.75)vs(38.10±1.85)pmol·g-1Pro,P<0.01〕;与单纯ISO组比较,IMD可呈剂量依赖性减轻心内膜下心肌缺血损伤,改善心功能,高剂量Intermedin治疗组大鼠优于低剂量组。结论ISO诱导的缺血损伤心肌的IMD受体上调,而IMD153对心肌缺血损伤具有明显的保护作用。 | 贾月霞 潘春水 耿彬 杨靖辉 赵晶 于芳 Helen Gerns OU-YANG Ming YANG Jun 唐朝枢 齐永芬 | 2005 | 中国药理学通报2005，21，12： | 11 |
| 2 | Relationship of viral infections to wheezing illnesses and asthma显示文摘 | Gern J E Busse W W | 2002 | Nature Rev Immunol2002，2，2： | 2 |
| 3 | Association of rhinovirus infections with asthma 显示文摘 | Gern JE Busse WW | 1999 | Clin Microbiol Rev1999，12，1： | 1 |
| 4 | The role of viral infections in the natural history of asthma显示文摘 | Gern JE Busse WW | 2000 | J Allergy Clin Immunol2000，106，3： | 1 |
| 5 | The role of viral infections in the natural history of asthma显示文摘 | Gern JE Busse WW | 2000 | J Allergy Clin Immunol2000，106，3： | 1 |
| 6 | Virus/allergen interactions in asthma 显示文摘 | Gavala M Bashir H Gern J E | 2013 | Curr Allergy Asthma Rep2013，13，3： | 1 |
| 7 | Viral respiratory tract infections and asthma: The course ahead显示文摘 | Louis A. Rosenthal Pedro C. Avila Peter W. Heymann Richard J. Martin E. Kathryn Miller Nikolaos G. Papadopoulos R. Stokes Peebles James E. Gern | 2010 | The Journal of Allergy and Clinical Immunology2010，，6： | 1 |
| 8 | Liquid silicon infiltration: description of infiltration dynamics and silicon carbide formation 显示文摘 | FRANK H GERN | 1997 | Composite Part A1997，28，： | 1 |
| 9 | Viral respiratory infection and the link to asthma显示文摘 | Gern JE | 2004 | Pediatr Infect Dis J2004，23，1： | 1 |
| 10 | Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infec- tion 显示文摘 | Gern J E Vrtis R Grindle K A | 2000 | Am J Respir Crit Care Med2000，162，6： | 1 |
| 11 | Viral respiratory infection and the link to asthma显示文摘 | Gern JE | 2008 | Pediatr Infect Dis J2008，27，10： | 1 |
| 12 | Peak flow variation in childhood asthma: a three-year analysis显示文摘 | GERN J E EC EGGLESTON P A SCHUBERTH K C | 1994 | J Allergy Clin Immunol1994，93，4： | 1 |
| 13 | Development of bipolar membranes 显示文摘 | Bauer B Gerne F J Strathmann H | 1988 | Desalination1988，68，2： | 1 |
| 14 | Viral and bacterial infections in the development and progression of asthma显示文摘 | Gern JE | 2000 | J Allergy Clin Immunol2000，，： | 1 |
| 15 | Vaccine-in- duced protection against 3 systemic mycoses endemic to North America requires Thl7 cells in mice 显示文摘 | WUTHRICH M GERN B HUNG C Y | 2011 | J Clin Invest2011，121，2： | 1 |
| 16 | Assessment of intraspecific mtDNA variability o f European Ixodes ricinus sensu Stricto (Acari: I xodidae) 显示文摘 | Casati S Bernasconi M V Gern L | 2008 | Infect Genet Evol2008，8，2： | 1 |
| 17 | Relationship of upper and lower airway cytokines to outcome of experimental rhinovirus infection 显示文摘 | Gern JE Vrtis R Grindle KA l | 2000 | Am J Respir Crit Care Med2000，162，6： | 1 |
| 18 | Resolution ofexperimental and tick-borne Borrelia burgdorferi infection in mice by passive, but not active immunization using recombinant OspC显示文摘 | Zhong W Gern L Stehle T | 1999 | Eur J Immunol1999，29，3： | 1 |
| 19 | The HeartMate Ⅲ:Design and In Vivo Studies of a Maglev Centrifu gal left Ventricular Assist Device显示文摘 | Loree HM Bourque K Gernes DB | 2001 | Artifical Organs2001，25，5： | 1 |
| 20 | Viral Respiratory Infection and the Link to Asthma显示文摘 | James E Gern M D | 2004 | Pediatr Infect Dis J2004，23，1： | 1 |
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