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| 1 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 2 | Dynamic response surface methodology using Lasso regression for organic pharmaceutical synthesis显示文摘To study the dynamic behavior of a process,time-resolved data are collected at different time instants during each of a series of experiments,which are usually designed with the design of experiments or the design of dynamic experiments methodologies.For utilizing such time-resolved data to model the dynamic behavior,dynamic response surface methodology(DRSM),a datadriven modeling method,has been proposed.Two approaches can be adopted in the estimation of the model parameters:stepwise regression,used in several of previous publications,and Lasso regression,which is newly incorporated in this paper for the estimation of DRSM models.Here,we show that both approaches yield similarly accurate models,while the computational time of Lasso is on average two magnitude smaller.Two case studies are performed to show the advantages of the proposed method.In the first case study,where the concentrations of different species are modeled directly,DRSM method provides more accurate models compared to the models in the literature.The second case study,where the reaction extents are modeled instead of the species concentrations,illustrates the versatility of the DRSM methodology.Therefore,DRSM with Lasso regression can provide faster and more accurate datadriven models for a variety of organic synthesis datasets. | Yachao Dong Christos Georgakis Jacob Santos-Marques Jian Du | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 2 |
| 3 | Pedestri- an- induced lateral vibrations of footbridges: A litera- ture review 显示文摘 | lngblfsson E T Georgakis C T JGnsson J | 2012 | Engineering Structures2012，45，： | 1 |
| 4 | Lack of c-kit (CD117) expression in CD30+ lymphomas and lymphomatoid papulosis显示文摘 | Rassidakis G Z Georgakis G V Dyaizo M | 2004 | Mod Pathol2004，17，8： | 1 |
| 5 | Duration of aortic cross-clamping during elective open abdominal aortic aneurysm repair opera-tions and postoperative cardiac/renal function显示文摘 | Georgakis P Paraskevas KI Bessias N | 2010 | Int Angiology2010，29，3： | 1 |
| 6 | Disturbance Detection and Isolation by Dynamic Principal Component Analysis 显示文摘 | KU W STORER R H GEORGAKIS C | 1995 | Chem Intell Lab Syst1995，30，： | 1 |
| 7 | Control of a solution copolymerization reactor using multi-model predictive control显示文摘 | OZKAN L KOTHARE M V GEORGAKIS C | 2003 | Chemical engineering science2003，58，7： | 1 |
| 8 | Disturbance detection and isolation by dynamic principal component analysis显示文摘 | Ku W Storer R H and Georgakis C | 2003 | Chemometrics and Intelligent Laboratory Systems2003，30，： | 1 |
| 9 | Heat-shock protein 90 inhibitors in cancer therapy : 17AAG and beyond 显示文摘 | Georgakis GV Younes A | 2005 | Future Oncol2005，1，2： | 1 |
| 10 | Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldan-amycin in Hodgkin's lymphoma ceils down-regulates Akt kinase,dephosphorylates extracellular signal-regulated kinase,and induces cell cycle arrest and cell death显示文摘 | Georgakis GV Li Y Rassidakis GZ | 2006 | Clin Cancer Res2006，12，2： | 1 |
| 11 | Disturbance detection and isolation by dynamic principal component analysis显示文摘 | KU W STORER R H GEORGAKIS C | 1995 | Chemometrics and Intelligent Laboratory Systems1995，30，1： | 1 |
| 12 | Effects of surface roughness and cross-sectional distortion on the wind-induced response of bridge cables in dry conditions 显示文摘 | Matteoni G Georgakis C T | 2015 | Journal of Wind Engineering and Industrial Aerodynamics2015，136，1： | 1 |
| 13 | Disturbance detection and isolation by dynamic principal component analysis显示文摘 | Ku W Storer R H Georgakis C | 1995 | Chemometrics and Intelligent Laboratory Systems1995，30，1： | 1 |
| 14 | Constructed wetlands treating highway runoff in the central Mediterranean region显示文摘 | Terzakis S Fountoulakis M S Georgaki I | 2008 | Chemosphere2008，72，2： | 1 |
| 15 | Reactive compatibilization of aliphatic polyamides with functionalized polyethylenes显示文摘 | Koulouri E G Georgaki A X Kallitsis J K | 1997 | Polymer1997，38，16： | 1 |
| 16 | Effect of bridge cable surface roughness and cross-sectional distortion on aerodynamic force coefficients显示文摘 | Matteoni G Georgakis C T | 2012 | Journal of Wind Engineering and Industrial Aerodynamics2012，104，： | 1 |
| 17 | From Rapa Nui to rapamycin:targeting PI3K/Akt/mTOR for cancer therapy显示文摘 | Younes A | 2006 | Expert Rev Anticaneer Ther2006，6，1： | 1 |
| 18 | Systematic Estimation of State Noise Statistics for Extended Kalman Filters显示文摘 | Jaleel Valappil Christos Georgakis | 2000 | AiChE journal/American institute of chemical engineers (S0001-1541)2000，46，2： | 1 |
| 19 | Systematic Estimation of State Noise Statistics for Extended Kalman Filters 显示文摘 | Jaleel Valappil Christos Georgakis | 2000 | AiChE Journal/ American Institute of Chemical Engineers (S0001-1541)2000，46，2： | 1 |
| 20 | Disturbance detection and isolation by dynamic principal component analysis 显示文摘 | KU W STORER R H GEORGAKIS C | 1995 | Chemometrics and Intelligent Laboratory Systems1995，30，1： | 1 |
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