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| 1 | Cell-free DNA integrity for the monitoring of breast cancer:Future perspectives?显示文摘Breast cancer(BC) is the most common cancer and the second cause of death in women worldwide. Therapeutic options are increasing, but the response to treatments is not always efficient and the risk of recurrence covers decades. In this perspective, the need to have a proper follow-up for the therapeutic responses and for anticipating recurrence it is urgent in the clinical setting. Liquid biopsy provides the basic principle for a non-invasive method for the routinely monitoring of BC. However, due to the heterogeneity of tumors during onset and progression, the search for tumor DNA mutations of targeted genes in plasma/serum is a limiting factor. A possible approach overtaking this problem comes from the measurement of cell-free DNA integrity, which is an independent factor from the mutational status and theoretically is representative of all tumors. This review summarizes the state-of-the-art of cell-free DNA integrity researches in BC, the controversies and the future perspective. | Navid Sobhani Daniele Generali Fabrizio Zanconati Marina Bortul Bruna Scaggiante | 2018 | World Journal of Clinical Oncology2018，9，2： | 2 |
| 2 | Double- blind, Placebo- controlled, Multicenter, Randomized, Phase iib neoadjuvant study of letrozole-lapatinib in post- menopausal hormone receptor-positive, Human epidermal growth factor receptor2-negative, Operable breast cancer 显示文摘 | Guameri V Generali DG Frassoldati A | 2014 | Clin 0ncol2014，32，10： | 1 |
| 3 | Clean-up of aqueous acetone vegetable extracts by solid-matrix partition for pyrethroid residue determination by gas - chromatography - electron - capture detection显示文摘 | MUCCIO A D BARBINI D A GENERALI T | 1997 | J Chromatogr A1997，765，： | 1 |
| 4 | Clean-up of aqueous acetone vegetable extracts by soild-matrix partition for pyrethroid residue determination by gas chromagraphy-electron-capture detection显示文摘 | Muccio A D Barbini D A Generali T | 1997 | J Chromatography A1997，765，： | 1 |
| 5 | Recombinant human growth horm- one: HIV-related lipodystrophy 显示文摘 | Generali JA Cada DJ | 2014 | Hosp Pharm2014，49，5： | 1 |
| 6 | Single-step separation of organochlorine pesticide residues from fatty materials by combined use of solid-matrix partition and C18 cartridges显示文摘 | MUCCIO A D GENERALI T BARBINI D A | 1997 | J Chromatogr A1997，765，： | 1 |
| 7 | International ex- pert consensus on primary systemic therapy in the manage- ment of early breast cancer: highlights of the Fourth Sympo- sium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010) 显示文摘 | Berruti A Generali D Kaufmann M | 2011 | J Natl Cancer Inst Monogr2011，，43： | 1 |
| 8 | COX-2 expression is predictive for early relapse and aromatase inhibitor resistance in patients with ductal carcinoma in situ of the breast,and is a target for treatment显示文摘 | Generali D Buffa FM Deb S | 2014 | Brit J Cancer2014，111，1： | 1 |
| 9 | Clean - up of aqueous acetone vegetable extracts by solid matrix partition for pyrethroid residue determination by gas chromatography electron - capture detection显示文摘 | Alfonso Di Muccio Danilo Attard Barbini Tiziana Generali | 1997 | J Chromatogr A1997，765，： | 1 |
| 10 | Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expres- sion in endothelial cell function显示文摘 | Patel N S Li J L Generali D Poulsom R Cranston D W Harris A L | 2005 | Cancer Res2005，65，： | 1 |
| 11 | Down-regulation of phosphatidylinositol3-kinase/AKT/molecular target of Rapamycin metabolic pathway by primary Letrozole-based therapy in human breast cancer显示文摘 | Generali D Fox SB Brizzi MP | 2008 | Clin Cancer Res2008，14，9： | 1 |
| 12 | Epithelial-mesenchymaltransition and breast cancer: role, molecular mechanisms and clini- cal impact显示文摘 | Foroni C Broggini M Generali D | 2012 | Cancer Treat Rev2012，38，6： | 1 |
| 13 | Interventional therapy in diabetic foot: risk, factors, clinical events and prognosis at one year follow-up (a study of 103 case$)显示文摘 | Ciccone MM Marchese A Generali A | 2012 | Pak J Biol Sci2012，15，16： | 1 |
| 14 | ADAM10 mediates trastuzttmab resistance and is correlated with survival in HER2 posi- tive breast cancer显示文摘 | Feldinger K Generali D Wong JH | 2014 | J Oncotarget2014，5，16： | 1 |
| 15 | Randomized phase II trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients 显示文摘 | Bottini A Generali D Brizzi MP | 2006 | J Clin Oncol2006，24，22： | 1 |
| 16 | Clean -up of aqueous acetone vegetable extracts by solid matrix partition for pyrethroid residue determination by gaschromatography-electron- capturedetection 显示文摘 | Alfonso Di MuccioDanilo Attard Barbini Tiziana Generali | 1997 | Journal ofChroma tographyA1997，765，4： | 1 |
| 17 | Epithelial-mesen- chymal transition and breast cancer: role, molecular mech- anisms and clinical impact 显示文摘 | Foroni C Broggini M Generali D | 2012 | Cancer Treat Rev2012，38，6： | 1 |
| 18 | Randomized phase Ⅱ trial of letrozole and letrozole plus low-dose metronomic oral cyclophosphamide as primary systemic treatment in elderly breast cancer patients显示文摘 | Bottini A Generali D Brizzi MP | 2006 | J Clin Oncol2006，24，22： | 1 |
| 19 | Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function显示文摘 | Patei NS Li JL Generali D | 2005 | Cancer Res2005，65，19： | 1 |
| 20 | Immunomodulation of FOXP3^+ regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients 显示文摘 | Generali D Bates G Berruti A | 2009 | Clin Cancer Res2009，15，3： | 1 |
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