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1Manufacturingartificial bone allografts:a perspective显示文摘Bone grafts have traditionally come from four sources:the patients’own tissue(autograft),tissue from a living or cadaveric human donor(allograft),animal donors(xenograft)and synthetic artificial biomaterials(ceramics,cement,polymers,and metal).However,all of these have advantages and drawbacks.The most commercially successful bone grafts so far are allografts,which hold 57%of the current bone graft market;however,disease transmission and scarcity are still significant drawbacks limiting their use.Tissue-engineered grafts have great potential,in which human stem cells and synthetical biomaterials are combined to produce bone-like tissue in vitro,but this is yet to be approved for widespread clinical practice.It is hypothesised that artificial bone allografts can be mass-manufactured to replace conventional bone allografts through refined bone tissue engineering prior to decellularisation.This review article aims to review current literature on(1)conventional bone allograft preparation;(2)bone tissue engineering including the use of synthetic biomaterials as bone graft substitute scaffolds,combined with osteogenic stem cells in vitro;(3)potential artificial allograft manufacturing processes,including mass production of engineered bone tissue,osteogenic enhancement,decellularisation,sterilisation and safety assurance for regulatory approval.From these assessments,a practical route map for mass production of artificial allografts for clinical use is proposed.Emma Steijvers Armaan Ghei Zhidao Xia 2022Biomaterials Translational2022,3,1:1
2Pathogenesis of hyperuricemia:recent advances 显示文摘Ghei M Mihailescu M Levinson D 2002Current Rheumatol- ogy Reports2002,4,3:1
3Pathogenesis of hyperuricemia:recent advances显示文摘Ghei M Mihailescu M Levinson D 2002Curr Rheumatol Rep2002,4,3:1
4Pathogenesis of hyperuricemia:Regent advances显示文摘Ghei M Mihailescu M Levinson D 2002Curr Rheumatol Rep*2002,4,3:1
5Supine per- cutaneous nephrolithotomy with endoscopic combined intra-renal sur- gery - results of the first one hundred patients from a single UK centre 显示文摘Ninaad S Awsare Maneesh Ghei Vellore Rajkumar 2013Journal of Clinical Urology2013,6,40:1
6Pathogenesis of hyperuricemia:recent advances 显示文摘Ghei M Mihailescu M Levinson D 2002Curr Rheumatol Rep2002,4,3:1
7Pathogenesis of hyper- uricemia:recent advances显示文摘Ghei M Mihailescu M Levinson D 2002Curr Rheumatol Rep2002,4,3:1
8Pathogenesis of hyperuricemia : recent advances 显示文摘Ghei M Minailescu M Levinson D 2002Curr Rheumatol Rep2002,4,3:1
9Pathogenesis of hyperuricemia:recent advances显示文摘 Mihailescu M Levinson D 2002Curr Rheumatol Rep2002,4,3:1
10Intravesical explosions during transurethral endoscopic procedures 显示文摘KHAN A MASOOD J GHEI M 2007Int Urol Nephrol2007,39,1:1
11Analysis of memory T lymphocyte activity following stimulation with overlapping HLA-A*2402,A*0101 and Cw*0402 restricted CMV pp65 peptides显示文摘Ghei M Stroncek DF Provenzano M 2005J Transl Med2005,3,:1
12Endoscopic management of upper tract urothelial carcino- ma 显示文摘Moore K Khastgir J Ghei M 2009Adv Urol2009,62,6:1
13Supine percutaneous nephrolithotomy with endoscopic combined intra - renal surgery - results of the first one hundred patients from a single UK centre 显示文摘Ninaad S Awsare Maneesh Ghei Vellore Rajkumar 2013Journal of Clinical Urology2013,6,6:1
14Pathogenesis of hyperuricemia:recent advances显示文摘Ghei M Mihaileseu M Levinson D 2002Curr Rheumatol Rep2002,4,3:1
15Intravesical explosions during transurethral endoscopic procedures显示文摘Khan A Masood J Ghei M et a/ 2007lnt Urol Nephrol2007,,:1
16Pathogenesis of hyperuricemia:recent advances显示文摘Ghei M Mihailescu M levinson D 2002Curr Rheumatol Rep2002,4,3:1
17MR imaging of hypoxic-isch- emic injury in term neonates : pearis and pitfalls 显示文摘Ghei SK Zan E Nathan JE 2014Radiograph- ics2014,34,4:1
18Inlravesical explosions during transure- tlaval endoscopic procedures显示文摘Khan A Masood J Ghei M 2007Int Urol Nephrol2007,39,17:1
19Pathogenisis of hyperuricemia:recent advances显示文摘Ghei M Mihailescu M Levison J 2002Curr Rheumatol Rep2002,,4:1
20Pathogenesis of hyperuricemia: recent advances显示文摘Ghei M Mihailescu M Levinson D 2002Curr Rheumatol Rep2002,4,:1
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