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| 1 | Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics显示文摘Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented. | Antonio Garcia-Gomez Fermin Sanchez-Guijo M Consuelo del Caizo Jesus F San Miguel Mercedes Garayoa | 2014 | World Journal of Stem Cells2014，6，3： | 5 |
| 2 | Analytical tools for the analysis of earotenoids in diverse materials 显示文摘 | Rivera S M Canela - Garayoa R | 2012 | Journal of Chromatography A2012，1224，： | 1 |
| 3 | Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients显示文摘 | Vicent S Garayoa M Lopez-Picazo JM | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 4 | Adrenomedullin is a cross talk molecule that regulates tumor and mast cell function during hu- man carcinogenesis显示文摘 | Zudaire E Martinez A Garayoa M | 2006 | Am J Pathol2006，168，： | 1 |
| 5 | Adrenomedullin in mammalian embryogenesis显示文摘 | Garayoa M Bodegas E Cuttitta F | 2002 | Microsc Res Tech2002，57，1： | 1 |
| 6 | Hypoxia inducible factor-1 up-regulate adrenomedullin expression in human tumor cell lines during oxygen deprivatin :a possible promotion mechanism of carcinogenesis 显示文摘 | Garayoa N Nartinez A | 2000 | Mol Endocrinol2000，14，16： | 1 |
| 7 | Bilateral Preiser's disease: a case re- port and review of the literature 显示文摘 | Amillo - Garayoa S Romero - Mufioz LM Pons - DeVillanueva J | 2011 | Musculoskelet Surg2011，95，2： | 1 |
| 8 | Ahernative splicing of the proadrenomedullin gene results in differential expression of gene products 显示文摘 | Martinez A Hodge DL Garayoa M | 2001 | J Mol Endocrinol2001，27，1： | 1 |
| 9 | Alternative splicing of the proadrenomedullin gene results in differential expression of gene products显示文摘 | Hodge DL Garayoa M | 2001 | J Mol Endocrinol2001，27，1： | 1 |
| 10 | HIF-1 up-regulates adrenomedullin expression in human tumor cell lines during oxyen deprivation:a possible promotion mechanism of carcinogenesis显示文摘 | Martinez A Lee S | 2000 | Mol Endocrinol2000，14，6： | 1 |
| 11 | Effects of acute hypoxia and lipopolysaccharide on nitric oxide synthase-2 expression in acute lung injury 显示文摘 | Agorreta J Garayoa M Montuenga LM | 2003 | Am J Respir Crit Care Med2003，168，2： | 1 |
| 12 | 显示文摘 | Millan Guilarte MT Oses Munarriz MI Garcia Garayoa JM | 2011 | Med Intensiva2011，35，7： | 1 |
| 13 | Food safety and the contract catering companies:Food handlers,facilities and HACCP evaluation显示文摘 | GARAYOA R VITAS A L LETURIA M D | 2011 | Food Control2011，22，12： | 1 |
| 14 | Hypoxia-nducible factor-1 (HIF-1) up-regulates Adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis显示文摘 | Garayoa M Martinez A Lee S | 2000 | Mol Endocrinol2000，14，6： | 1 |
| 15 | Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis显示文摘 | Garayoa M Martinez A Lee S | 2000 | Mol Endocrinol2000，14，6： | 1 |
| 16 | Chemical and biological characterization of new Re( CO)3/^99mTc(CO) 3 bombesin analogues显示文摘 | Garcia Garayoa E Ruegg D Blauenstein P | 2007 | Nucl Med Biol2007，34，1： | 1 |
| 17 | Hypoxia-inducible factor-1 ( HIF-1 ) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation:a possible promotion mechanism of carcinogensis 显示文摘 | Garayoa M Martinez A Lee S | 2000 | Mol Endocrino12000，14，： | 1 |
| 18 | Hypoxia-inducible factor-1(HIF-1)up-regulates adren omedullin expression in human tumor cell lines dur-ing oxygen deprivation:a possible promotion mechanism of carcinogenesis显示文摘 | Garayoa M Martinez A Lee S Pio R An W G Neckers L | 2000 | Mol Endocrinol2000，14，： | 1 |
| 19 | Hypoxia-inducible factor-1 (HIF-1) up-regulates Adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis 显示文摘 | Garayoa M Martinez A Lee S | 2000 | Mol Endocrinol2000，14，6： | 1 |
| 20 | Adrenomedullin functions as an important tumor survival factor in human carcinogenesis 显示文摘 | Cuttittia F Pio R Garayoa M | 2002 | Microsc Res Tech2002，57，2： | 1 |
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