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| 1 | Narrow-band imaging with magnifying endoscopy is accurate for detecting gastric intestinal metaplasia显示文摘AIM:To investigate the predictive value of narrowband imaging with magnifying endoscopy (NBI-ME) for identifying gastric intestinal metaplasia (GIM) in unselected patients. METHODS:We prospectively evaluated consecutive patients undergoing upper endoscopy for various indications, such as epigastric discomfort/pain, anaemia, gastro-oesophageal reflux disease, suspicion of peptic ulcer disease, or chronic liver diseases. Patients underwent NBI-ME, which was performed by three blinded, experienced endoscopists. In addition, five biopsies (2 antrum, 1 angulus, and 2 corpus) were taken and examined by two pathologists unaware of the endoscopic findings to determine the presence or absence of GIM. The correlation between light blue crest (LBC) appearance and histology was measured. Moreover, we quantified the degree of LBC appearance as less than 20% (+), 20%-80% (++) and more than 80% (+++) of an image field, and the semiquantitative evaluation of LBC appearance was correlated with IM percentage from the histological findings. RESULTS:We enrolled 100 (58 F/42 M) patients who were mainly referred for gastro-esophageal reflux disease/dyspepsia (46%), cancer screening/anaemia (34%), chronic liver disease (9%), and suspected celiac disease (6%); the remaining patients were referred for other indications. The prevalence of Helicobacter pylori (H. pylori ) infection detected from the biopsies was 31%, while 67% of the patients used proton pump inhibitors. LBCs were found in the antrum of 33 patients (33%); 20 of the cases were classified as LBC+, 9 as LBC++, and 4 as LBC+++. LBCs were found in the gastric body of 6 patients (6%), with 5 of them also having LBCs in the antrum. The correlation between the appearance of LBCs and histological GIM was good, with a sensitivity of 80% (95%CI:67-92), a specificity of 96% (95%CI:93-99), a positive predictive value of 84% (95%CI:73-96), a negative predictive value of 95% (95%CI:92-98), and an accuracy of 93% (95%CI:90-97). The NBI-ME examination overlooked GIM in 8 cases, but the GIM was less than 5% in 7 of the cases. Moreover, in the 6 false positive cases, the histological examination showed the presence of reactive gastropathy (4 cases) or H. pylori active chronic gastritis (2 cases). The semiquantitative correlation between the rate of LBC appearance and the percentage of GIM was 79% (P < 0.01). CONCLUSION:NBI-ME achieved good sensitivity and specificity in recognising GIM in an unselected population. In routine clinical practice, this technique can reliably target gastric biopsies. | Edoardo Savarino Marina Corbo Pietro Dulbecco Lorenzo Gemignani Elisa Giambruno Luca Mastracci Federica Grillo Vincenzo Savarino | 2013 | World Journal of Gastroenterology2013，19，17： | 23 |
| 2 | Role of Arabidopsis UV RESISTANCE LOCUS 8 in Plant Growth Reduction under Osmotic Stress and Low Levels of UV-B显示文摘在热点环境,植物暴露于压力的不同类型,例如触发普通 morphogenic 的 UV-B,而且 droughtstress 的过量适应反应导致植物生长的一般减小。这里,我们 reportthat Arabidopsis thaliana 紫外抵抗地点 8 (UVR8 ) 基因, UV-B morphogenic 反应的一个已知的管理者,能补充 Saccharomyces cerevisiae osmo 敏感的异种和它的表示在 Arabidopsis 植物在渗透或咸的应力以后被导致。在 UV-B 的底层下面,植物 overexpressing UVR8 与减少的根开发被相形见绌并且与控制植物相比积累更多的 flavonoids。生长 defectsare 主要由于细胞扩大的抑制。UVR8 overexpression 在 UV-B 的底层下面在植物触发的生长抑制被导致甘露糖醇的渗透的应力加重,但是它不是由离子的应力的 significantlyaffected。相反, uvr8-6 异种植物不在标准条件下面不同于野类型的植物,但是他们显示出一个增加的射击生长 underhigh 盐压力。我们的数据建议 flavonoid 并且可能的调停 UVR8 的累积在植物生长素 homeostasisare 改变观察生长显型的内在的机制并且 UVR8 可能为 integratingplant 生长和压力 signals.Key 词有一个重要角色: | Rossella Fasano Nathalie Gonzalez Alessandra Tosco Fabrizio Dal Piaz Teresa Docimo Ramon Serrano Stefania Grillo Antonella Leone Dirk Inze | 2014 | Molecular Plant2014，7，5： | 7 |
| 3 | Gut microbiota,inflammatory bowel disease and colorectal cancer显示文摘The gut microbiota is a complex community of microorganisms that inhabit the digestive tracts of humans,living in symbiosis with the host.Dysbiosis,characterized by an imbalance between the beneficial and opportunistic gut microbiota,is associated with several gastrointestinal disorders,such as irritable bowel syndrome(IBS);inflammatory bowel disease(IBD),represented by ulcerative colitis and Crohn’s disease;and colorectal cancer(CRC).Dysbiosis can disrupt the mucosal barrier,resulting in perpetuation of inflammation and carcinogenesis.The increase in some specific groups of harmful bacteria,such as Escherichia coli(E.coli)and enterotoxigenic Bacteroides fragilis(ETBF),has been associated with chronic tissue inflammation and the release of pro-inflammatory and carcinogenic mediators,increasing the chance of developing CRC,following the inflammationdysplasia-cancer sequence in IBD patients.Therefore,the aim of the present review was to analyze the correlation between changes in the gut microbiota and the development and maintenance of IBD,CRC,and IBD-associated CRC.Patients with IBD and CRC have shown reduced bacterial diversity and abundance compared to healthy individuals,with enrichment of Firmicute sand Bacteroidetes.Specific bacteria are also associated with the onset and progression of CRC,such as Fusobacterium nucleatum,E.coli,Enterococcus faecalis,Streptococcus gallolyticus,and ETBF.Future research can evaluate the advantages of modulating the gut microbiota as preventive measures in CRC high-risk patients,directly affecting the prognosis of the disease and the quality of life of patients. | Ana Elisa Valencise Quaglio Thais Gagno Grillo Ellen Cristina Souza De Oliveira Luiz Claudio Di Stasi Ligia Yukie Sassaki | 2022 | World Journal of Gastroenterology2022，28，30： | 7 |
| 4 | HER2 heterogeneity in gastric/gastroesophageal cancers: From benchside to practice显示文摘HER2 is overexpressed in approximately 10%-20% of gastric and gastroesophageal junction carcinomas. In these types of cancer, accurate assessment of HER2 status is mandatory, for selecting patients who may benefit from targeted therapies with anti-HER2 drugs such as Trastuzumab. This manuscript focuses on HER2 in gastric carcinogenesis, on optimal evaluation of HER2 and on the possible causes which may contribute to inaccurate HER2 evaluation. Similarly to breast cancer HER2 evaluation, standardization of HER2 testing in gastric cancer is necessary in diagnostic practice. The three principle aspects which require consideration are:(1) the choice of sample with regards to cancer morphology- intestinal vs diffuse areas;(2) the choice of scoring criteria- use of HER2 scoring criteria specific for gastric cancer; and(3) the choice of HER2 evaluation methods- use of an algorithm in which both immunohistochemistry and in situ hybridization play a role. Problematic issues include:(1) pre-analytic variables with particular emphasis on fixation;(2) recommended methodology for HER2 assessment(immunohistochemistry vs in situ hybridization);(3) HER2 heterogeneity both within the primary tumor and between primary tumor and metastases;(4) reliability of biopsies in HER 2 evaluation; and(5) quantity of sample(FFPE blocks from surgical specimens or endoscopic biopsies) necessary for an adequate assessment. | Federica Grillo Matteo Fassan Francesca Sarocchi Roberto Fiocca Luca Mastracci | 2016 | World Journal of Gastroenterology2016，22，26： | 3 |
| 5 | MicroRNA expression in inflammatory bowel disease-associated colorectal cancer显示文摘MicroRNAs(miRNAs)are non-coding RNA molecules composed of 19–25 nucleotides that regulate gene expression and play a central role in the regulation of several immune-mediated disorders,including inflammatory bowel diseases(IBD).IBD,represented by ulcerative colitis and Crohn’s disease,is characterized by chronic intestinal inflammation associated with an increased risk of colorectal cancer(CRC).CRC is one of the most prevalent tumors in the world,and its main risk factors are obesity,physical inactivity,smoking,alcoholism,advanced age,and some eating habits,in addition to chronic intestinal inflammatory processes and the use of immunosuppressants administered to IBD patients.Recent studies have identified miRNAs associated with an increased risk of developing CRC in this population.The identification of miRNAs involved in this tumorigenic process could be useful to stratify cancer risk development for patients with IBD and to monitor and assess prognosis.Thus,the present review aimed to summarize the role of miRNAs as biomarkers for the diagnosis and prognosis of IBD-associated CRC.In the future,therapies based on miRNA modulation could be used both in clinical practice to achieve remission of the disease and restore the quality of life for patients with IBD,and to identify the patients with IBD at high risk for tumor development. | Thais Gagno Grillo Ana Elisa Valencise Quaglio Rodrigo Fedatto Beraldo Talles Bazeia Lima Julio Pinheiro Baima Luiz Claudio Di Stasi Ligia Yukie Sassaki | 2021 | World Journal of Gastrointestinal Oncology2021，13，9： | 2 |
| 6 | The As and Ds of stress:metabolic,morphological and behavioral consequences显示文摘 | Reagan LP Grillo CA Piroli GG | 2008 | Eur J Pharmacol2008，585，1： | 1 |
| 7 | Intracranial hemorrhage in infants due to vitamin K deficiency-report of 2 cases显示文摘 | Grillo E Silva RJM Filho JHB | 2000 | J Pediatr2000，76，2： | 1 |
| 8 | Elevated levers ofC-reactive protein atdischange in patientswith unstable angina predict recurrent instability显示文摘 | Biasucci LM Liuzzo G Grillo RL | 1999 | Circulation1999，99，： | 1 |
| 9 | S-Adenosylmethionine and Its Products显示文摘 | Grillo MA Colombatto S | 2008 | Amino Acids2008，34，2： | 1 |
| 10 | The limits of tracheal resection with primary anastomosis显示文摘 | Mulliken JB Grillo HC | 1968 | J Thorac Cardiovasc Surg1968，55，： | 1 |
| 11 | Rituxmab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program显示文摘 | Mclaughlin P Grillo Lopez A J Link B K | 1998 | J Clin Oncol1998，16，8： | 1 |
| 12 | laryngotracheal Resection and Reconstruction for subglottic stenosis显示文摘 | Grillo He Mathisen DJ Wain JC | 1992 | Ann Thorac Surg1992，53，： | 1 |
| 13 | Development of tracheal surgery:a history review显示文摘 | Grillo HC | 2003 | Ann Thorac Surg2003，75，3： | 1 |
| 14 | Endoanal ultrasound-guided surgery for anal fistula显示文摘 | Ratto C Grillo E Parello A | 2005 | Endoscopy2005，37，： | 1 |
| 15 | Control of in- tracellular calcium signaling as a neuroprotective strategy显示文摘 | DUNCAN RS GOAD DL GRILLO MA | 2010 | Molecules2010，15，3： | 1 |
| 16 | Management of con- genital tracheal stenosis by means of slide tracheoplasty or resec- tion and reconstruction, with long-term follow-up of growth after slide tracheoplasty显示文摘 | Grillo HC Wright CD Vlahakes GJ | 2002 | J Thorac Cardiovasc Surg2002，123，1： | 1 |
| 17 | Uncommon Primary Tracheal Tumors显示文摘 | Gaissert HA Grillo HC Shadmehr MB | 2006 | Ann Thorac Surg2006，82，1： | 1 |
| 18 | Impact of nutrition on outcome : a prospective randomized controlled trial in patients with head and neck cancer undergoing radiotherapy显示文摘 | RAVASCO P MONTEIRO GRILLO I MARQUES VIDAL P | 2005 | Head Neck2005，27，8： | 1 |
| 19 | Tetranuclear manganese complexes with dimer-of-dimer and ladder structures from the use of a bis-bipyridyl ligand 显示文摘 | Sanudo E C Grillo V A Christou G | 2002 | Inorg Chem2002，41，： | 1 |
| 20 | Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability显示文摘 | Biasucci LM Liuzzo G Grillo RL | 1999 | Circulation1999，99，： | 1 |
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