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| 1 | The suppressors of cytokine signaling (SOCS) proteins:Important feedback inhibitors of cytokine action 显示文摘 | Nicola N A Greenhalgh C J | 2000 | Exp Hematol2000，28，10： | 4 |
| 2 | Overview of extended release tacrolimus in solid organ transplantation显示文摘Tacrolimus(Prograf?, Astellas Pharma Europe Ltd, Staines, United Kingdom; referred to as tacrolimusBID) is an immunosuppressive agent to prevent and treat allograft rejection in kidney transplant recipients in combination with mycophenolate mofetil, corticosteroids,with or without basiliximab induction. The drug has also been studied in liver, heart and lung transplant; however, these are currently off-label indications. An extended release tacrolimus formulation(Advagraf?, Astagraf XL?) allows for once-daily dosing, with the potential to improve adherence. Extended release tacrolimus has similar absorption, distribution, metabolism and excretion to tacrolimus-BID. Phase Ⅰ pharmacokinetic trials comparing extended release tacrolimus and tacrolimus-BID have demonstrated a decreased maximum concentration(C max) and delayed time to maximum concentration(t max) with the extended release formulation; however, AUC0-24 was comparable between formulations. Overall extended release tacrolimus has a very similar safety and efficacy profile to tacrolimus-BID. It is not recommended in the use of liver transplant patient's due to the increased risk of mortality in female recipients. There has been minimal data regarding the use of extended release tacrolimus in heart and lung transplant recipients. With the current data available for all organ groups the extended release tacrolimus should be dosed in a 1:1 fashion, the exception may be the cystic fibrosis population where their initial dose may need to be higher. | Neha Patel Abigail Cook Elizabeth Greenhalgh Megan A Rech Joshua Rusinak Lynley Heinrich | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 3 | Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats显示文摘 | Pradillo JM Denes A Greenhalgh AD | 2012 | J Cereb Blood Flow Metab2012，32，9： | 1 |
| 4 | Systematic review of the application of quality improvement methodolo- gies from the manufacturing industry to surgical healthcare 显示文摘 | Nicalay CR Purkayastha S Greenhalgh A | 2012 | Br J Surg2012，99，3： | 1 |
| 5 | Recurrent epidemic cycles in an infectious disease model with a time delay in loss of vaccine immunity 显示文摘 | Greenhalgh D Khan Q J A Lewis F I | 2005 | Nonl Anal TMA2005，63，6： | 1 |
| 6 | Systematic review of the application of quality improvement methodologies from the manufacturing industry to surgical healthcare显示文摘 | Nicolay C R Purkayastha S Greenhalgh A | 2012 | Br J Surg2012，99，3： | 1 |
| 7 | Principal compo- nent transforms of triaxial recordings by singular value de- composition显示文摘 | Jackson G M Mason I M Greenhalgh S A | 1991 | Geophysies1991，56，4： | 1 |
| 8 | Crosshole seismic inversion with normalized full-waveform amplitude data显示文摘 | Zhou B Greenhalgh S A | 2003 | Geophysics2003，68，4： | 1 |
| 9 | Laser imaging of fuel injection systems and combustors 显示文摘 | Greenhalgh D A | 1991 | Proceedings of the Institution of Mechanical Engineers1991，214，4： | 1 |
| 10 | 2D Laser induced fluorescence imaging o parent fuel fraction in nonpremixed combustion显示文摘 | Tait N P Greenhalgh D A | 1992 | Proceedings of Combustion Institute1992，24，： | 1 |
| 11 | Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats 显示文摘 | Pradillo JM Denes A Greenhalgh AD | 2012 | J Cereb Blood Flow Metab2012，32，9： | 1 |
| 12 | Systematic comparison of the early outcome of angioplasty and endarterectomy for symptomatic carotid artery disease显示文摘 | Golledge J Mitchell A Greenhalgh RM | | 0，，： | 1 |
| 13 | Surface seismic imaging by multi-frequency amplitude inversion显示文摘 | Greenhalgh S A Zhou B | 2003 | Exploration Geophysics2003，34，4： | 1 |
| 14 | Thrombocytopenia-absent radius syndrome:a clinical genetic study显示文摘 | Greenhalgh KL Howell RT Bottani A | 2002 | J Med Genet2002，39，12： | 1 |
| 15 | Delayed administra- tion of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats显示文摘 | Pradillo J M Denes A Greenhalgh A D | 2012 | J Cereb Blood Flow Metab2012，32，9： | 1 |
| 16 | Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats显示文摘 | Pradillo JM Denes A Greenhalgh AD | 2012 | J Cereb Blood Flow Metab2012，32，： | 1 |
| 17 | Solutions,Algo- rithms and Inter-Relations for Local Minimization Search Geophysical Inversion显示文摘 | Greenhalgh S A Bing Z Green A | 2006 | J Geophys Eng2006，5，： | 1 |
| 18 | Linear and parabolic t-p transforms revisited 显示文摘 | Zhou B Greenhalgh S A | 1994 | Geophysics1994，59，： | 1 |
| 19 | Systematic review of the application of quality improvement methodologies from the manufacturing industry to surgical healthcare显示文摘 | Nicolay CR Purkayastha S Greenhalgh A | 2012 | British Journal of Surgery2012，99，3： | 1 |
| 20 | Prestack multicomponent migration 显示文摘 | Zhe J P Greenhalgh S A | 1997 | Geophysics1997，62，2： | 1 |
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